The title compound, [Zn2(C8F4O4)2(C4H8O)2]n, has a three-dimensional metal-organic framework structure. The asymmetric unit consists of two ZnII atoms, two tetrahydrofuran ligands, one 2,3,5,6-tetrafluorobenzene-1,4-dicarboxylate ligand and two half 2,3,5,6-tetrafluorobenzene-1,4-dicarboxylate ligands, which are completed by inversion symmetry. One ZnII atom has a distorted trigonal–bipyramidal coordination geometry, while the other has a distorted octahedral geometry. Two independent tetrahydrofuran ligands are each disordered over two sets of sites with occupancy ratios of 0.48 (4):0.52 (4) and 0.469 (17):0.531 (17).