In the construction of prefabricated buildings, safety issues occur frequently, posing challenges to project progress and personnel safety. As a new trend in the construction industry, the complexity of the environment in prefabricated construction demands an update to traditional safety management concepts. This study introduces the concept of resilience to analyze safety issues in prefabricated construction and develops a WSR-4Rs framework for a systematic evaluation of construction safety. The study first combines the WSR (Wuli-Shili-Renli) systematic methodology with the 4R resilience theory to construct an evaluation index system for construction safety. Then, it uses the Analytic Hierarchy Process (AHP) and the entropy weight method to determine the combined weights of each index, establishing a balanced and objective weighting scheme. A fuzzy comprehensive evaluation model is then applied to assess actual project cases. Finally, an obstacle degree model is introduced to identify key indicator factors that significantly impact construction safety, and specific improvement measures are proposed based on these findings. The aim is to provide practical references and guidance for enhancing the safety management level in prefabricated construction.