Industrial automation is embracing wireless sensor-actuator networks (WSANs). Despite the success of WSANs for monitoring applications, feedback control poses significant challenges due to data loss and stringent energy constraints in WSANs. Holistic control adopts a cyber-physical system approach to overcome the challenges by orchestrating network reconfiguration and process control at run time. Fundamentally, it leverages self-awareness across control and wireless boundaries to enhance the resiliency of wireless control systems. In this article, we explore efficient holistic control designs to maintain control performance while reducing the communication cost. The contributions of this work are five-fold: (1) We introduce a holistic control architecture that integrates Low-power Wireless Bus (LWB) and two control strategies, rate adaptation and self-triggered control ; (2) We present heuristics-based and optimal rate selection algorithms for rate adaptation; (3) We design novel network adaptation mechanisms to support rate adaptation and self-triggered control in a multi-hop WSAN; (4) We build WCPS-RT, a real-time network-in-the-loop simulator that integrates MATLAB/Simulink and a physical WSAN testbed to evaluate wireless control systems; (5) We empirically explore the tradeoff between communication cost and control performance in holistic control approaches. Our studies show that rate adaptation and self-triggered control offer advantages in control performance and energy efficiency, respectively, in normal operating conditions. The advantage in energy efficiency of self-triggered control, however, may diminish under harsh physical and wireless conditions due to the cost of recovering from data loss and physical disturbances.