Weighted Mean Estimates Research Articles

New subclass of meromorphic harmonic functions defined by symmetric q-calculus and domain of Janowski functions

In this article, by applying the convolution principle and symmetric q-calculus, we develop a new generalized symmetric q-difference operator of convolution type, which is applicable in the domain E⁎={τ:τ∈C and 0<|τ|<∞}. Utilizing this operator, we construct, analyze, and evaluate two new sets of meromorphically harmonic functions in the Janowski domain. Furthermore, we investigate the convolution properties and necessary conditions for a function F to belong to the class MSHP,R(q,q−1), examining the sufficiency conditions for F to satisfy these properties. Moreover, we examine key geometric properties of the function F in the class MSH‾P,R(q,q−1), including the distortion bound, convex combinations, the extreme point theorem, and weighted mean estimates.

The influence of vertical ridge augmentation techniques on peri-implant bone loss: A systematic review and meta-analysis.

The primary aim of this systematic review was to investigate and compare the outcomes of different vertical ridge augmentation (VRA) techniques in relation to peri-implant bone loss (PBL), after at least 12 months of functional loading. The search was conducted to find all the studies about VRA and measurements of PBL with at least 12 months follow-up. Three pairwise meta-analysis (MA) was performed to completely evaluate the outcomes. A total of 42 studies were included, of which 11 were randomized clinical trials (RCTs). RCTs were available only for guided bone regeneration (GBR), onlay, and inlay techniques. The weighted mean estimate (WME) of PBL value was found to be 1.38 mm (95% confidence interval [95% CI]: 1.10-1.66) after a mean follow-up of 41.0 ± 27.8 months. GBR, Inlay, Onlay, osteodistraction, and SBB represented in weight 32.9%, 30.6%, 25.0%, 7.6%, and 3.9%, respectively; and their WME (95% CI) were 1.06 (0.87-1.26) mm, 1.72 (1.00-2.43) mm, 1.31 (0.87-1.75) mm, 1.81 (0.87-1.75) mm, and 0.66 (0.55-0.77) mm, respectively. Among the secondary outcomes, the analysis was conducted for vertical bone gain, healing complication rate, surgical complication rate, implant survival, and success rate. The primary findings of the meta-analysis, based on the changes between final and baseline values, showed that the peri-implant bone loss could be influenced by the type of intervention but there is a need to evaluate in RCTs the behavior of the peri-implant bone levels after long-term follow-up for all techniques.

Clustering of metabolic and behavioural risk factors for cardiovascular diseases among the adult population in South and Southeast Asia: findings from WHO STEPS data.

The aim of this study is to assess the current status of metabolic and behavioural risk factors for cardiovascular diseases among the adult population in South and Southeast Asia using World Health Organization (WHO) STEPS data. We used WHO STEPS surveys data in ten South and Southeast Asian countries. Weighted mean estimates of prevalence of five metabolic risk factors and four behavioural risk factors were calculated by country and overall region. We used random-effects meta-analysis to generate country and regional pooled estimates of metabolic and behavioural risk factors, using the DerSimonian and Laird inverse-variance method. Around 48,434 participants aged 18-69 years were included in this study. Overall 32.00% (95% CI: 31.15-32.36) of individuals in the pooled sample had one metabolic risk factor, 22.10% (95% CI: 21.73-22.47) had two, and 12.38% had three or more (95% CI: 9.09-14.00). Twenty-four percent (95% CI: 20.00-29.00) of individuals in the pooled sample had only one behavioural risk factor, 49.00% (95% CI: 42.00-56.00) had two, and 22.00% had three or more (95% CI: 16.00-29.00). Risk of high three or more metabolic risk factors was higher among women, those of older age, and those with a higher education. The existence of multiple metabolic and behavioural risk factors among the South and Southeast Asian population demand appropriate prevention strategies to halt the progress of non-communicable disease burden within the region. Not applicable.

Sign of Observed California Temperature Trends Depends on Data Set Homogenization: Implications for Weighting and Downscaling

AbstractBecause downscaling methods can yield substantially different projections of future climate, it is imperative to constrain these projections with information from existing observations, while also recognizing observational uncertainty. California is a natural test case to develop observational constraints on future projections given prior studies that have purportedly found contrasting spatial patterns in late‐20th‐century trends of summertime daily‐maximum temperature: cooling along the coast and warming inland. Revisiting this claim, we find that coastal cooling is largely confined to non‐homogenized temperature records while homogenized observations show either non‐significant cooling or warming trends throughout the state. This finding has implications for weighting historical and future climate simulations downscaled using localized constructed analogs. Failure to consider out‐of‐sample skill results in weighted and unweighted Representative Concentration Pathway 8.5 temperature trend estimates differing by 2 K/century or more in California. However, weighted mean estimates that properly account for trend uncertainty do not differ significantly from the unweighted mean.

Prevalence of multiple non-communicable diseases risk factors among adolescents in 140 countries: A population-based study.

SummaryBackgroundModifiable non-communicable disease (NCD) risk factors are becoming increasingly common among adolescents, with clustering of these risk factors in individuals of particular concern. The aim of this study was to assess global status of clustering of common modifiable NCD risk factors among adolescents.MethodsWe used latest available data from nationally representative survey for 140 countries, namely the Global School-based Student Health Survey, the Health Behaviour in School-Aged Children and the longitudinal study of Australian Children. Weighted mean estimates of prevalence with corresponding 95% confidence intervals of nine NCD risk factors - physical inactivity, sedentary behaviour, insufficient fruits and vegetable consumption, carbonated soft drink consumption, fast food consumption, tobacco use, alcohol consumption and overweight/obesity - were calculated by country, region and sex.FindingsOver 487,565 adolescents, aged 11–17 years, were included in this study. According to trend analysis, prevalence of four or more NCD risk factors increased gradually over time. Prevalence of four or more NCD risk factors was 14.8% in 2003–2007 and increased to 44% in 2013–2017, an approximately three-fold increase (44.0%). Similar trends were also observed for three and two risk factors. Large variation between countries in the prevalence of adolescents with four or more risk factors was found in all regions. The country level range was higher in the South-East Asia Region (minimum Sri Lanka = 8%, maximum Myanmar = 84%) than Western Pacific Region (minimum China = 3%, maximum Niue = 72%), European Region (minimum Sweden = 13.9%, maximum Ireland = 66.0%), African Region (minimum Senegal = 0.8%, maximum Uganda = 82.1%) and Eastern Mediterranean Region (minimum Libya = 0.2%, maximum Lebanon = 80.2%). Insufficient vegetable consumption, insufficient fruit consumption and physically inactivity were three of the four most prevalent risk factors in all regions.InterpretationOur results suggest a high prevalence of four or more NCD risk factors in adolescents globally, although variation was found between countries. Results from our study indicate that efforts to reduce adolescent NCD risk factors and the associated health burden need to be improved. These findings can assist policy makers to target the rollout of country- specific interventions.FundingNone.

Exploring Hepatocellular Carcinoma Mortality Using Weighted Regression Estimation for the Cohort Effect in Taiwan from 1976 to 2015.

To estimate the cohort effects that remove the efficacy of age and the period in the age-period statistics of a contingency table, the multiphase method is put forward. Hepatocellular carcinoma (HCC) is one of the most common malignancies of the liver. Understanding the predictive effects of age, period, and cohort on HCC mortality trends may help to estimate the future HCC burden, identify etiological factors, and advise public health prevention programs. Estimates of future HCC mortality and the associated health burden were forecast using an age–period–cohort (APC) model of analysis. By running a regression of residuals that were isolated from the median polish stage of cohort classification, the study controlled for HCC mortality confounding variables and interpreted time trends in HCC rates. The literature shows that the weighted mean estimation derived from the confidence interval (CI) is relatively restricted (compared to the equal-weighted evaluation). This study aimed to illustrate the effects of age, period, and cohort on the incidence and mortality rates, along with the weight equivalent to the segment of death number caused by HCC in each cohort. The objective of that work was to evaluate the proposed method for appraising cohort effects within the age-period data of contingency tables. The weighted mean estimate from the regression model was found to be robust and thus warrants consideration in forecasting future HCC mortality trends. The final phase was factored in to calculate the magnitude of cohort effects. In conclusion, owing to the relatively constricted CI and small degree of uncertainty, the weighted mean estimates can be used for projections based on simple linear extrapolation.

Metaanalysis of recurrence and survival after resection for pancreatic neuroendocrine tumours (PNETs)

Introduction: There is paucity of data regarding recurrence patterns after resection of PNETs. This systematic review aimed to appraise the literature regarding the recurrence rates and survival outcomes for various grades of resected PNETs. Method: A systematic search was performed in PUBMED, MEDLINE, and EMBASE databases using the PRISMA frame work. The data analysis included weighted disease free survival (DFS); overall survival (OS) and weighted median recurrence rates for various grades of PNETs. Results: Following the literature search, 18 studies with a total of 3588 patients met the inclusion criteria. The number of patients with Grade 1, 2, 3 PNETs respectively was 57, 97 and 27. The DFS and OS at 10 years for the entire cohort was 88.6% (CI 76.6-94.9) and 65.7% (CI 52.7-76.6) respectively. The mean time to recurrence was 41 months and overall recurrence rate was 18 %. 14 studies reported site of recurrence with liver being the most common site with recurrence rate of 11%. The weighted mean estimate for loco-regional recurrence was 2.7%. 9/17 studies reported grade specific recurrence. The overall recurrence rate for G1, G2 and G3 tumours was 6 %, 33 % and 85% respectively. Conclusion: Liver recurrence is more frequent than loco regional recurrence after surgery for PNETs. In spite of good survival outcomes, the risk of recurrence persists even after 10 years warranting ongoing surveillance.

Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: A meta-analysis.

ObjectivesLennox‐Gastaut syndrome (LGS) is among the most severe epileptic and developmental encephalopathies. A meta‐analysis was performed to evaluate the effectiveness of adjunctive vagus nerve stimulation (VNS Therapy) in patients with LGS.Materials & MethodsPubMed database was queried (January 1997 to September 2018) to identify publications reporting on the efficacy of VNS Therapy in patients with LGS, with or without safety findings. Primary endpoint of the meta‐analysis was the proportion of responders (≥50% reduction in seizure frequency). Random‐effects analysis was used to calculate weighted mean estimates and confidence intervals. Heterogeneity was evaluated by statistical tests including I 2.ResultsOf 2752 citations reviewed, 17 articles (480 patients) were eligible including 10 retrospective studies and seven prospective studies. A random‐effects model produced a pooled proportion of 54% (95% confidence intervals [CI]: 45%, 64%) of patients with LGS who responded to adjunctive VNS Therapy (p for heterogeneity <0.001, I 2=72.9%). Per an exploratory analysis, the calculated incidence of serious adverse events associated with VNS Therapy was 9% (95% CI: 5%, 14%); the rate was higher than in long‐term efficacy studies of heterogeneous cohorts with drug‐resistant epilepsy and likely attributed to variable definitions of serious adverse events across studies.ConclusionsThe meta‐analysis of 480 patients with LGS suggests that 54% of patients responded to adjunctive VNS Therapy and that the treatment option was safe and well‐tolerated. The response in patients with LGS was comparable to heterogeneous drug‐resistant epilepsy populations. A clinical and surgical overview has been included to facilitate the use of VNS in LGS.

A method for estimating the certified value uncertainty of a multicomponent reference material

This paper presents the results of a series of studies aimed at investigating the reference material (RM) of a multicomponent solution. An algorithm for estimating the uncertainty induced by the chemical element content in the RM is proposed taking into account the mass of the measurand in each component of the mixture. The results calculated according to the preparation procedure using the proposed algorithm were confirmed by the Monte Carlo method, while the elemental content in the mixture was confirmed via inductively coupled plasma optical emission spectroscopy. The applicability of weighted mean estimates for characterizing an RM of a multicomponent solution is shown.

Difference in Clinical Behavior of the Pancreatic Adenocarcinomas versus Pancreatic Neuroendocrine Tumors (PNETs) - A Systematic Review and Meta-Analysis

Introduction: The pancreatic adenocarcinomas and pancreatic neuroendocrine tumors (PNETs) are two distinct type of cancers and it is critical to understand the difference in clinical course, diagnostic and treatment patterns. This study aims to determine the difference in clinical behavior of pancreatic adenocarcinoma vs PNETs. Methods: A comprehensive literature search was performed using different search engines. A total of 26 studies on adenocarcinoma and 53 studies on PNET were included in the analysis. The information extracted was only focused on the variables describing clinical behavior (signs or symptoms). The weighted mean estimates with corresponding 95% confidence intervals were obtained between the adeno and non-adeno groups separately, along with each study within the two groups. Mean differences were also obtained across the corresponding variables. SAS version 9.4 was used. Results: A total of 5493 patients were identified with 4373 having adenocarcinoma. The weighted percentage was reported for age, gender, anatomical location and cancer subtypes as shown in Figure. 1. Comparison of the most common manifestations:: As seen in Figure 2A, the top 9 most common manifestations are described for each particular category of cancer. The abdominal pain was the most common variable reported in both categories. Comparison of the overlapping common manifestations: Among the nine most common symptoms, adenocarcinoma and PNET overlapped in the 4 manifestations as shown in 2B. The average mean difference was reported to compare the rate of different variables as seen in table.1. PNETs category was found to have more percentage of males, smoking, the location of the tumor in body and tail, weight loss, diarrhea, diarrhea, and fever. Similarly, adenocarcinoma was associated with more female population, tumor location in the head, abdominal pain, jaundice, fatigue, anemia, and nausea.107_A Figure 1. Age, gender, anatomical location and classification of pancreatic cancer in the literature.107_B Figure 2. Top 9 signs and symptoms. Figure 2B: Comparison between the common manifestations in adenocarcinoma and PNETPNETs subtypes manifestation: Based on the analyses of specific PNET subtypes, we found the most frequently reported manifestations by reported prevalence are: weight loss in Glucagonoma (74.19%), weight gain in Insulinoma (36.71%), diarrhea in VIPoma (100%), abdominal pain in somatostatinoma (45.45%), ZES (75.50%) and nonfunctional tumor (40.00%). Conclusion: The clinical manifestations vary depending upon the type of pancreatic cancer. Our study results will help decipher the clinical pattern of the particular type of pancreatic cancer. However, studies need to be done to further delineate the exact pattern.107_C Figure 3. Differences between Non-Adenocarcinoma vs Adenocarcinoma

Predictive physiological anticipatory activity preceding seemingly unpredictable stimuli: An update of Mossbridge et al’s meta-analysis

Background: This is an update of the Mossbridge et al’s meta-analysis related to the physiological anticipation preceding seemingly unpredictable stimuli which overall effect size was 0.21; 95% Confidence Intervals: 0.13 - 0.29 Methods: Nineteen new peer and non-peer reviewed studies completed from January 2008 to June 2018 were retrieved describing a total of 27 experiments and 36 associated effect sizes. Results: The overall weighted effect size, estimated with a frequentist multilevel random model, was: 0.28; 95% Confidence Intervals: 0.18-0.38; the overall weighted effect size, estimated with a multilevel Bayesian model, was: 0.28; 95% Credible Intervals: 0.18-0.38. The weighted mean estimate of the effect size of peer reviewed studies was higher than that of non-peer reviewed studies, but with overlapped confidence intervals: Peer reviewed: 0.36; 95% Confidence Intervals: 0.26-0.47; Non-Peer reviewed: 0.22; 95% Confidence Intervals: 0.05-0.39. Similarly, the weighted mean estimate of the effect size of Preregistered studies was higher than that of Non-Preregistered studies: Preregistered: 0.31; 95% Confidence Intervals: 0.18-0.45; No-Preregistered: 0.24; 95% Confidence Intervals: 0.08-0.41. The statistical estimation of the publication bias by using the Copas selection model suggest that the main findings are not contaminated by publication bias. Conclusions: In summary, with this update, the main findings reported in Mossbridge et al’s meta-analysis, are confirmed.

Derived Optimal Linear Combination Evapotranspiration (DOLCE): a global gridded synthesis ET estimate

Abstract. Accurate global gridded estimates of evapotranspiration (ET) are key to understanding water and energy budgets, in addition to being required for model evaluation. Several gridded ET products have already been developed which differ in their data requirements, the approaches used to derive them and their estimates, yet it is not clear which provides the most reliable estimates. This paper presents a new global ET dataset and associated uncertainty with monthly temporal resolution for 2000–2009. Six existing gridded ET products are combined using a weighting approach trained by observational datasets from 159 FLUXNET sites. The weighting method is based on a technique that provides an analytically optimal linear combination of ET products compared to site data and accounts for both the performance differences and error covariance between the participating ET products. We examine the performance of the weighting approach in several in-sample and out-of-sample tests that confirm that point-based estimates of flux towers provide information on the grid scale of these products. We also provide evidence that the weighted product performs better than its six constituent ET product members in four common metrics. Uncertainty in the ET estimate is derived by rescaling the spread of participating ET products so that their spread reflects the ability of the weighted mean estimate to match flux tower data. While issues in observational data and any common biases in participating ET datasets are limitations to the success of this approach, future datasets can easily be incorporated and enhance the derived product.

The effects of habitat, climate, and Barred Owls on long-term demography of Northern Spotted Owls

ABSTRACT Estimates of species' vital rates and an understanding of the factors affecting those parameters over time and space can provide crucial information for management and conservation. We used mark–recapture, reproductive output, and territory occupancy data collected during 1985–2013 to evaluate population processes of Northern Spotted Owls (Strix occidentalis caurina) in 11 study areas in Washington, Oregon, and northern California, USA. We estimated apparent survival, fecundity, recruitment, rate of population change, and local extinction and colonization rates, and investigated relationships between these parameters and the amount of suitable habitat, local and regional variation in meteorological conditions, and competition with Barred Owls (Strix varia). Data were analyzed for each area separately and in a meta-analysis of all areas combined, following a strict protocol for data collection, preparation, and analysis. We used mixed effects linear models for analyses of fecundity, Cormack-Jolly-...

Genetic selection for wool quality.

Abstract This paper reviews the feasibility of genetic selection for wool quality. More than 30 papers were studied in the present investigation. The traits which have been considered in the majority of the literature for inclusion in the selection programmes were: (a) wool quality traits (fibre diameter, staple length, staple strength, standard deviation of fibre diameter, coefficient variation of fibre diameter, yield and crimp frequency) and (b) wool weight traits (greasy fleece weight and clean fleece weight). Before the studied traits can be proposed as the selection traits, estimates of genetic parameters as well as their relationship with other production traits are needed. Weighted mean of estimates for direct heritability ( h 2 ), maternal heritability ( m 2 ) and variance ration due to permanent maternal environment ( P 2 ) from references 1-37 were calculated to be 0.30-0.61, 0.02-0.08 and 0.03-0.16, respectively. The studied breeds were wool breeds and dual-purpose (wool and meat) breeds. In wool breeds, the weighted mean estimates of genetic correlation were ranged from -0.53 to 0.84 among wool traits and were ranged from -0.38 to 0.25 between wool traits and other traits such as live bodyweight, litter size at birth, litter size at weaning and litter weight weaned. The high estimates of h 2 indicate that the response to selection may be reliable but the unfavourable genetic (phenotypic) correlations with other traits are a concern.

Information Theoretic Weighted Mean Based on Truncated Ranked Set Sampling

This article proposes using an information theoretic procedure in order to obtain an unbiased weighted mean estimator for the population mean when the data collection structure is truncated-based ranked set sampling. The performance of the proposed estimator is discussed along with its properties, and the optimal weights are computed by maximizing Shannon’s entropy. It is found that the weighted truncated-based ranked set sampling estimator is more accurate and more efficient than its unweighted counterpart or the simple random sampling-based estimators.

Pathological and problem gambling in substance use treatment: A systematic review and meta-analysis

Pathological and problem gambling refer to a class of disorders, including those meeting criteria for a psychiatric diagnosis (i.e., pathological gambling), and others comprising a spectrum of severity defined by significant personal and social harm (i.e., problem gambling), that may be common in substance use treatment but are frequently unrecognized. This paper presents a systematic review and meta-analysis of available evidence indicating the prevalence of such gambling disorders in substance use treatment. It provides weighted mean estimates from across studies of clinical samples of substance users, and suggests around 14% of patients that demonstrate comorbid pathological gambling. Around 23% suffer conditions along the broader spectrum of problem gambling. The review also highlights important limitations of existing evidence, including scant data on current versus lifetime comorbidity, as well as reliance on convenience samples and self-administered measures of gambling problems. Notwithstanding a concomitant need for caution when applying these results, the findings suggest a strong need to identify and manage gambling comorbidity in substance use treatment. Strategies for identification of gambling disorders, and therapies that may provide useful adjunctive interventions in substance use treatment are discussed.

Meta-analysis of genetic parameter estimates for reproduction, growth and carcass traits of pigs in the tropics

The design of swine breeding programs for the tropics requires knowledge of genetic parameters for economically important traits determined under tropical conditions. A literature review found a total of 468 heritability (h2) estimates, 368 genetic correlations and 254 phenotypic correlations for 35 traits across 117 peer-reviewed articles published from 1974 to 2009 and covering tropical Africa, Southeast Asia, the Caribbean and Latin America. A model that incorporated between and within study variance component was used to obtain weighted means and variances for all parameter estimates. Weighted means and standard errors of direct and maternal heritability, common litter effects and the correlation between direct and maternal effects are given for various reproduction, growth and carcass traits. The weighted means and confidence intervals for the genetic and phenotypic correlations between the trait groups are also given. Weighted least-squares analyses of the h2 estimates were performed by fitting a number of fixed effects and covariates for each trait as appropriate for the data. Breed, data origin, estimation method, data age and location of study were found to be significant (P<0.05) for majority of the traits analysed. These results indicate the relevance of having local, population-specific genetic parameter estimates for the tropics. The weighted mean estimates of genetic parameters presented here are recommended for use when reliable estimates are not available for a specific tropical pig population. This is quite appropriate because it uses the vast resource of published genetic parameter estimates effectively.

A Statistical Method for Synthesizing Meta-Analyses

Multiple meta-analyses may use similar search criteria and focus on the same topic of interest, but they may yield different or sometimes discordant results. The lack of statistical methods for synthesizing these findings makes it challenging to properly interpret the results from multiple meta-analyses, especially when their results are conflicting. In this paper, we first introduce a method to synthesize the meta-analytic results when multiple meta-analyses use the same type of summary effect estimates. When meta-analyses use different types of effect sizes, the meta-analysis results cannot be directly combined. We propose a two-step frequentist procedure to first convert the effect size estimates to the same metric and then summarize them with a weighted mean estimate. Our proposed method offers several advantages over existing methods by Hemming et al. (2012). First, different types of summary effect sizes are considered. Second, our method provides the same overall effect size as conducting a meta-analysis on all individual studies from multiple meta-analyses. We illustrate the application of the proposed methods in two examples and discuss their implications for the field of meta-analysis.

Statistical Properties of Alternative National Forest Inventory Area Estimators

The statistical properties of potential estimators of forest area for the USDA Forest Service's Forest Inventory and Analysis (FIA) program are presented and discussed. The current FIA area estimator is compared and contrasted with a weighted mean estimator and an estimator based on the Polya posterior, in the presence of nonresponse. Estimator optimality is evaluated both theoretically and via simulation under bias and mean squared error criteria.The results indicate that, under realistic conditions, the current FIA area estimator can sometimes result in substantial bias and have a higher mean squared error than both of the alternative estimators. This finding is of special interest because the same factor that contributes to this increased bias and variance applies to all area-based FIA estimates. The weighted mean and Polyha posterior estimators gave similar results for estimating the total area of a domain. It is concluded that the main advantage of the latter approach is that many other statistics are obtainable because the entire population distribution is estimated from the same sampling effort. The cost of this advantage for the Polya posterior approach is that a single result requires many more computer operations, a cost that has become virtually ignorable over the past decade.

1086P - Aggregated Analysis of Reported Efficacy for Salvage Autologous Stem-Cell Transplantation for Myeloma

ABSTRACT The rate of complete response (CR) achieved soon after autologous stem cell transplantation (ASCT) is often used as a measure of relative success when comparing interventions in similar or randomized identical settings. New therapies are often tried in salvage and rescue settings early on in development and some of these therapies may electively or necessarily be combined with ASCT also in the rescue/salvage setting. Response rates in such settings are anecdotally low however few studies exist and many variables confound their understanding not least of which is the small numbers of patients involved. Methods A pubmed/medline/googlescholar search strategy along with hand-searching key haematology and oncology journal archives and key paper bibliographies was adopted. 13 published cohorts were identified that reported CR as an outcome from second/salvage ASCT across a total of 1064 patients ( table 1 ). Reported data that included patients who did not have measurable disease (i.e. already in CR) going into the second transplant were excluded as the intent was to observe salvage ASCT effects in measurable disease. Complete response rate (CR), Event free survival/Progression free survival (EFS ∼ PFS were considered heuristically similar) and overall survival (OS) were aggregated. Weighted mean estimates (WME) of efficacy were derived for each setting adjusted according to the number of patients associated with each CR rate. Table: 1086P . CR rate % Number of patients PFS/EFS Months OS Months Krishnan 2011 35 295 Olin 2007 5 41 8.5 20.7 N Shah 2011 11 44 12.3 31.7 Simpson 2007 33 45 12.5 30.6 Jiminez 2011 7 81 Mehta 1998 33 42 12.5 32 Qazilbash 2006 21.4 14 6.8 29 Elice 2006 3.8 26 14.8 38.1 Giaccone 2011 17.4 46 Cavo 2007 19.4 103 Sirohi 2002 31.3 94 10.5 15 Rosinol 2012 11 85 Cook 2011 26 148 Sum 1064 Weighted Average 23.8 11.3 20.8 Results The WME CR rate after a second ASCT was calculated to be ∼24%. Aggregated WME of EFS was 11.2 months and OS 20.8 months. Conclusions Complete responses can be expected in approximately 1 in 4 patients who are selected for clinical trials and given a second transplant for relapsed or non-responding disease. Variability in reported rates is considerable.CR rate Percent Number of Patients PFS/EFS months OS months Disclosure D.P. Smethurst: Full time employee of Immunocore Ltd. and Consultant to Adaptimmmune Ltd. Share options in Immunocore Ltd. and Adaptimmune Ltd.