Abstract
Introduction: There is paucity of data regarding recurrence patterns after resection of PNETs. This systematic review aimed to appraise the literature regarding the recurrence rates and survival outcomes for various grades of resected PNETs. Method: A systematic search was performed in PUBMED, MEDLINE, and EMBASE databases using the PRISMA frame work. The data analysis included weighted disease free survival (DFS); overall survival (OS) and weighted median recurrence rates for various grades of PNETs. Results: Following the literature search, 18 studies with a total of 3588 patients met the inclusion criteria. The number of patients with Grade 1, 2, 3 PNETs respectively was 57, 97 and 27. The DFS and OS at 10 years for the entire cohort was 88.6% (CI 76.6-94.9) and 65.7% (CI 52.7-76.6) respectively. The mean time to recurrence was 41 months and overall recurrence rate was 18 %. 14 studies reported site of recurrence with liver being the most common site with recurrence rate of 11%. The weighted mean estimate for loco-regional recurrence was 2.7%. 9/17 studies reported grade specific recurrence. The overall recurrence rate for G1, G2 and G3 tumours was 6 %, 33 % and 85% respectively. Conclusion: Liver recurrence is more frequent than loco regional recurrence after surgery for PNETs. In spite of good survival outcomes, the risk of recurrence persists even after 10 years warranting ongoing surveillance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
