Uric Acid Creatinine Ratio Research Articles

Evaluation of the diagnostic value of the HALP score, uric acid value, and uric acid-creatinine ratio in preeclampsia.

In this study, we aimed to evaluate the diagnostic value of the HALP score, serum uric acid value, and uric acid-creatinine ratio, which are inflammatory markers, in the diagnosis of preeclampsia (PE). One hundred sixty-six pregnant women who met the inclusion and exclusion criteria were included in the study. They were divided into two groups: 81 pregnant women diagnosed with PE (PE group) and 85 pregnant women with healthy pregnancies (control group). Demographic and obstetric stories of the groups; weeks of pregnancy at diagnosis; hematological and biochemical parameters; hemoglobin, albumin, lymphocyte, and platelet (HALP) score and serum uric acid-creatinine ratio (sUA/sCr); and the results of the newborns were recorded and compared between groups. There was no significant difference between the groups in terms of age, gravidity, parity, and body mass index (P values = 0.533, 0.188, 0.085, 0.915, resp.). Mean gestational age, mean birth weight, 1st and 5th minute Apgar scores, and mean umbilical cord pH values were lower in the PE group compared to the control group (P values = 0.0001 for all). Percentage of NICU admissions was higher in the PE group (P = 0.0001). HALP score of the PE group was significantly lower than the control group (2.2 vs. 3.2; P = 0.0001). Uric acid and sUA/sCr ratios were significantly higher in the PE group compared to the control group (for uric acid, 6.2 ± 1.7 vs. 4.5 ± 1.2; P = 0.0001; for sUA/sCr, 12.0 ± 4.0 vs. 9.9 ± 3.1; P = 0.0001). In diagnosing PE, serum uric acid had a sensitivity of 82.7% at values of 4.7 and above, 58% sensitivity at values of sUA/sCr ratio of 10.9 and above, and 3.7% sensitivity at HALP score values of 6.6 and above (P values = 0.0001, 0.001, 0.001, resp.). In our study, we found that the HALP score in PE was significantly lower than in healthy controls, and the uric acid value and sUA/sCr ratios were significantly higher. Diagnostic value of the serum uric acid value and then the sUA/sCr ratio were higher in PE. However, we found that the HALP score was insufficient for diagnosing PE.

Diagnostic performance of sixteen biomarkers for MASLD: A study in a Mexican cohort

Background and aimsMetabolic Dysfunction-associated Steatotic Liver Disease (MASLD) poses a heightened cardiovascular risk. Identifying efficient biomarkers for early MASLD detection in resource-limited Latin American regions is crucial. We aimed to evaluate the diagnostic efficacy of sixteen biomarkers for MASLD in Mexican individuals. MethodsIn this cross-sectional and analytical study, steatosis was assessed using vibration-controlled transient elastography. MASLD was defined according to international standards. Assessed biomarkers included: Visceral Fat (VF), Waist Circumference (WC), Waist-Height Ratio (WHtr), Waist-Hip Ratio (WHr), Visceral Adiposity Index (VAI), Hepatic Steatosis Index (HSI), Body Mass Index (BMI), Homeostatic Model Assessment (HOMA), Weight-Adjusted-Waist Index (WWI), Lipid Accumulation Product (LAP), Uric Acid-Creatinine Ratio (UACR), Triglyceride-Glucose Index (TyG) and its variants TyG-WC, TyG-HDL, TyG-BMI, TyG-WHtr. Results161 participants were included, of which 122 met MASLD criteria (56 % women, age 53.9 years [47.5–64]) and 39 were healthy controls (76 % women, age 52 [45–64]). The AUROCs of the biomarkers for MASLD were: TyG-WC (0.84), LAP (0.84), TyG-BMI (0.82), TyG-WHtr (0.80), WC (0.78), TyG (0.77), WHtr (0.75), BMI (0.76), VF (0.75), HSI (0.75), TyG-HDL (0.75), WHr (0.72), VAI (0.73), UA/CR (0.70), HOMA (0.71), and WWI (0.69). Sex-based differences were observed. After adjusting for sociodemographic variables, the TyG-WC index was the best predictor of MASLD. ConclusionsIn conclusion, our results underscore the potential of several noninvasive biomarkers for MASLD assessment in a Mexican population, highlighting variations in diagnostic efficacy and cut-off values between sexes. After adjusting, TyG-WC was the best MASLD predictor.

Serum uric acid: creatinine ratio (UCR) is associated with recurrence of atrial fibrillation after catheter ablation.

Studies showed that elevated preoperative serum uric acid(SUA) levels are associated with recurrence of atrial fibrillation(AF) after catheter ablation. UA:creatinine ratio(UCR - UA normalised for renal function) has appeared as a new biomarker and is considered to reflect endogenous UA levels preferably because it eliminates the influence of renal function. This study aimed to investigate the correlation between UCR and recurrence of AF after catheter ablation. A total of 233 consecutive patients with symptomatic, drug-refractory AF underwent catheter ablation. All participants underwent history-taking, physical examination and blood biochemistry analysis at baseline. After a mean follow-up of 23.99 ± 0.76 months, recurrence ratios for each UCR quartile (from lowest quartile to highest) were 10.9%, 23.6%, 23.6%, and 41.8%, respectively (P = 0.005). Multivariate Cox regression analysis revealed that UCR was an independent predictor of AF recurrence (HR 1.217, 95%CI 1.008-1.468; P = 0.041). Subgroup analysis showed that UCR was associated with AF recurrence in paroxysmal AF (HR 1.426, 95% CI 1.092-1.8608; P = 0.009) and in male patients (HR 1.407, 95% CI 1.015-1.950; P = 0.04). A cut-off point of 4.475 for the UCR had sensitivity of 65.5% and specificity of 59.6% in predicting AF recurrence (P = 0.001). Our results demonstrate that elevated preoperative UCR is associated with recurrence of AF after catheter ablation, and it indicate UCR maybe a predictive factor for the recurrence of AF.

Association between Serum Uric Acid Levels and Primary Open-angle Glaucoma: A Cross-sectional Study

Introduction: There is an intricate association between serum Uric Acid (UA) levels and Primary Open Angle Glaucoma (POAG). UA levels in the blood are known to be a good indicator of antioxidant function, and a decrease in UA plays a key role in the pathogenesis of POAG. However, the association of serum UA and Uric Acid Creatinine Ratio (UACR) in POAG cases in the Indian population remains unexplored. Aim: To investigate the association of serum UA levels and serum UACR with POAG. Materials and Methods: This cross-sectional study was conducted among patients who attended the Outpatient Department (OPD) of Opthalmology at Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India. The duration of the study was one year and six months, from January 15, 2021 to July 15, 2022. The study included 200 recently diagnosed patients with POAG, who were divided into three groups based on Intraocular Pressure (IOP): Group 1 (mild) with an IOP of 21-30 mmHg, group 2 (moderate) with an IOP of 31-50 mmHg, and group 3 (severe) with an IOP greater than 51 mmHg. Age and gender-matched 199 healthy subjects were included as the control group. Blood samples were collected from the study subjects after obtaining informed consent and were tested for serum UA (using the modified Trinder method) and serum creatinine (using Jaffe’s method) in a semiautomatic analyser (Erba chem 7). The data were analysed using Statistical Package for Social Sciences (SPSS) version 21.0 software and MS Excel 2007. Results: The mean age of the study participants of all three groups was found to be 51.19±5.06 years with 46.7% male and 53.3% female subjects. The serum UA levels were 5.55±0.74 mg/dL in the mild POAG group, 4.1±0.5 mg/dL in the moderate POAG group, and 2.67±0.6 mg/dL in the severe POAG group (p-value <0.001). The present study also found that among the three study groups of POAG, UA levels were the lowest in the severe POAG group, followed by the moderate POAG group, and then the mild POAG group. This pattern was observed in both the males and females population. Conclusion: The present study found that serum UA levels were decreased in POAG patients compared to the normal healthy control group. Furthermore, the study revealed a significant negative association between serum UA levels and serum UACR levels with the severity of POAG.

Estimated excretion and clearance of uric acid as optimal surrogate indices for daily urinary uric acid excretion.

Daily uric acid excretion (Eua) is an essential index for patients with gout/hyperuricaemia. We identified alternative indices most correlated with 24-hour uric acid clearance (Cua 24 h) and 24-hour Eua (Eua 24 h) using data from the reference interval of urinary clearance and excretion of urate study. The subjects were indoor workers aged 20-65 years who met the Clinical and Laboratory Standards Institute Guidelines C28-A3c. Alternative indices using spot urine were urine uric acid creatinine ratio, Cua-creatinine clearance ratio (Cua/Ccr), Eua-CCr ratio (Eua/Ccr), estimated Cua (eCua), and estimated Eua (eEua). eCua and eEua are the values obtained by multiplying Cua/Ccr and Eua/Ccr with the estimated glomerular filtration rate. The final number of subjects analysed was 739. Among the indices using spot urine, eCua and eEua showed the highest correlation with Cua 24 h and Eua 24 h, respectively. Compared with Cua 60 min and Eua 60 min obtained from 60-min urine collection, eCua and eEua showed lower root means squared error, lower bias, and significantly higher accuracy of within 30% and within 15%. The newly proposed eCua and eEua may be appropriate from a practical perspective.

Are Uric Acid and Uric Acid Creatinine Ratio Predictors for Mortality in Acute Exacerbations of Chronic Obstructive Pulmonary Disease?

Amaç: Kronik Obstrüktif Akciğer Hastalığı (KOAH) klinik seyrinde, kötü prognoza neden olan, ek
 tedavi gerektiren, solunum semptomlarında (dispne, öksürük, balgam) kötüleşme olarak tanımlanan
 alevlenmeler gözlenebilir. Maliyet-etkin mortalite öngörücüleri, KOAH’ın tedavi yönetimi için değerlidir.Akut KOAH alevlenmeleri olan serum ürik asit (ÜA) ve serum ürik asitin kreatinine oranının (ÜKO) mortalite ve hipoksemi için belirleyici olup
 olmadığını araştırmayı amaçladık.
 Gereç ve Yöntemler: Bu gözlemsel kesitsel çalışmada, Ocak 2014 ile Aralık 2018 arasında bir referans göğüs hastanesinde yatan 105
 KOAH alevlenmesindeki hasta retrospektif olarak değerlendirildi. ÜA ve ÜKO ile uzun vadeli mortalite, hipoksemi, komorbidite, FEV1 değeri,
 KOAH’ın tanı, tedavi ve önlenmesi için küresel strateji (GOLD) evreleri arasındaki ilişkiler analiz edildi.
 Bulgular: KOAH alevlenmesindeki toplam 105 hastayı (97’si erkek, ortalama yaş 65±9 yıl) içeren bu çalışmada hiperürisemi ile mortalite
 arasında anlamlı bir korelasyon bulunurken (sırasıyla, p=0.027; p=0.016), ÜKO ile mortalite arasında korelasyon bulunmadı (sırasıyla,
 p=0.051, p=0.053). Düşük ÜA seviyesi hipoksemi ile anlamlı olarak ilişkiliydi (p=0.022), ancak ÜKO ile hipoksemi arasında bir ilişki gözlenmedi
 (p=0.094).
 Sonuç: KOAH alevlenmesindeki hastaların uzun vadeli mortalitesini öngörmede serum ÜA’nin ÜKO’na göre daha değerli olduğu
 görülmektedir. Sık klinik takip ve yoğun tedavi yönetimi gerektiren yüksek riskli KOAH hastalarının tanımlanması için serum ÜA’in uzun
 vadeli mortalitenin biyobelirteci olarak kullanılabileceğini öneriyoruz.

Spot Urine Uric Acid to Creatinine Ratio used in the Estimation of Hyperuricosuria in the Young Korean Population

Background: Uric acid levels in urine are measured using urine specimens 24 hours or by uric acid glomerular filtration rate (UAGFR) with spot urine, which additionally requires a blood sample. This study aimed to investigate whether urinary uric acid creatinine ratio (UUACr) obtained by spot urine alone could be recognized as a substitute for UAGFR value, and hyperuricosuria can be screened by UUACr. UUACr is known to vary with age and regional differences. This study focused on the reference value of each value in Korean young populations.Method: We enrolled Korean subjects 1–20 years with normal kidney function, from a single hospital, classified into 5 age groups, 1–5 years, 6–8 years, 9–12 years, 13–15 years, and 16–20 years. We checked spot urine uric acid, creatinine and serum uric acid, creatinine levels on the same day from February 2014 to December 2018. We measured the average of UAGFR and UUACr in each groups. The UUACr cut-off value of the upper 2 standard deviation (SD) of UAGFR were taken.Results: The upper 2 SD of UUACr (mg/mg) and UAGFR (mg/dL) were determined in all age groups. UUACr decreased with grown up (P=0.000), but UAGFR were not statistically different among the groups. UUACr and UAGFR were not significantly different by gender. UUACr and UAGFR were positively correlated; UUACr cut-off value of upper 2 SD UAGFR (0.54 mg/dL) was 0.65 mg/mg in total age.Conclusions: UUACr could potentially be used to screen for hyperuricosuria.

Urine Uric Acid Creatinine Ratio as a Diagnostic and Prognostic Marker of Neonatal Birth Asphyxia

Background: Cerebral hypoxia can result in anaerobic glycolysis which leads to decreased phosphorylase production and increased uric acid which gets excreted in the urine where it can be easily detected. The aim of the study is to assess the utility of urine uric acid creatinine ratio (UA/Cr) as an additional marker of neonatal depression and birth asphyxia and its utility as a potential prognostic indicator for the immediate outcome. Subjects and Methods: It was a case-control study that included 30 newborns born with an APGAR score of less than 7 at 1-min and requiring positive pressure ventilation. Cases were sub-grouped into neonatal depression and birth asphyxia. Newborns with moderate and severe encephalopathy were considered to have an unfavourable outcome. The urine UA/Cr was estimated in both groups. One-way Anova test, Spearman’s rho and Receiver Operating Characteristic curve were used for statistical analysis. Results: The mean differences of urine UA/Cr were statistically significant (p=0.011) in birth asphyxia (3.02 1.34), neonatal depression (2.31 0.81) and controls (2.01 0.69). A significant negative correlation was seen with APGAR at 1-min (r=-0.43; p=0.001) and 5-min (r=-0.52; p=0.001) and umbilical cord blood pH (r= -0.29; p=0.021). The mean difference of UA/Cr between those with unfavorable (3.23 1.49) and favourable (2.14 0.73) outcomes was significant (p=0.006). A ratio 2.85 suggested the unfavourable outcome. Conclusion: The urine UA/Cr is a useful diagnostic and prognostic biomarker in newborns with birth asphyxia.

Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia

Background Asphyxia is one of the leading causes of death inthe world. Prematurity (28%), sepsis (26%), and asphyxia (23%)are the most common causes of death in newborns. In Indonesia,the newborn mortality incidence is 82 per 1,000 live births. BloodpH is a routine laboratory examination to diagnose newbornasphyxia, but it is preferrable to avoid such invasive procedures innewborns. An examination of urinary uric acid-creatinine (UA/Cr) ratio may be useful as an alternative method for diagnosisof asphyxia. Hypoxia causes anaerobic metabolism which willincrease the blood acidity, while creatinine will decline as a resultof incomplete renal function in newborns.Objective To assess for a possible correlation between blood pHand urinary UA/Cr ratio in newborn asphyxia.MethodsWe conducted an observational, cross-sectional study inProf. Dr. R. D. Kandou Hospital, Manado, North Sulawesi, fromNovember 2013 to April 2014. Subjects were full term newbornswith asphyxia. Blood pH and urinary UA/Cr ratio were comparedwith Pearson’s correlation test. Data was analyzed with SPSSversion 22 software and P values <0.05 were considered to bestatistically significant.Results Forty subjects met the inclusion criteria. Theirpredominant risk factor for asphyxia was fetal distress. Subjects’mean blood pH was 7.1 (SD 0.1) and mean urinary UA/Cr ratio was3.7 (SD 1.9). There was a moderate negative correlation betweenblood pH and urinary UA/Cr ratio (r= -0.55; P<0.001).Conclusion In newborns with asphyxia, lower blood pH iscorrelated with higher urinary UA/Cr ratio.

Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia

Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia

Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia

Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia

Uric acid excretion in infectious mononucleosis: a function of increased purine turnover.

ABSTRACT Uric acid excretion was studied in patients with infectious mononucleosis during the acute and convalescent phases and in control groups of patients with nonspecific upper respiratory infections. Fifty-five percent of the patients with acute infectious mononucleosis had serum uric acids greater than 8.0 mg/100 ml. Urinary uric acid excretion and uric acid/creatinine ratios were significantly greater in the acute phase than in the convalescent or control groups, and draws attention to the possible development of uric acid nephropathy. The uric acid-creatinine ratio was greater than 0.60 in 80% of our patients and appears to be a suitable method for detecting increased purine turnover in infectious mononucleosis. This data supports the hypothesis that the hyperuricemia of infectious mononucleosis is due to increased purine turnover.

A FILTER PAPER SAMPLING METHOD FOR THE URIC ACID:CREATININE RATIO IN URINE

In the article: A Filter Paper Sampling Method for the Uric Acid-Creatinine Ratio in Urine: Normal Values in the Newborn, Pediatrics, 49:80 (January) 1972, the last sentence of the Results section should read: We were unable to obtain and test urine samples which had been collected during the first week of life from known patients with the Lesch-Nyhan Syndrome.

Relation of emotional responses and changes in plasma hydrocortisone level after stressful interview.

Various natural and experimental situations generally considered to be psychologically stressful are capable of influencing the activity of the adrenal cortex. Auto racing, 1 competitive rowing, 2 paratroop training, 3 anticipation of surgery, 4 and college examinations 5 produce a significant diminution in the blood eosinophil level, and experimental frustration raises the urinary uric acid-creatinine ratio. 6 Following the introduction of more direct estimates of adrenocortical activity by measurements of plasma hydrocortisone level and urinary hydroxycorticosteroid excretion, participation in an accident, taking a college examination, 7 being admitted to a mental hospital during acute emotional disturbance, 8 and taking part in a stressful psychiatric interview 9,10 have also been shown to increase adrenocortical functioning. It is generally taken for granted that these are all situations that most people find difficult and trying, and that some find very disturbing. Yet it is well known that there are many individual responses to

Adrenal Cortical Steroids Jollowing Elective Operations

In the quest for a better evaluation of the indications for the therapeutic use of corticotropin (ACTH) and of adrenocortical steroids (cortisone, etc.) in surgical diseases, more about the nature and degree of the adrenocortical response to operation must be known. To this end, investigators have used a number of methods, including measurements of certain adrenocortical steroids and their metabolic products excreted in the urine, the eosinophile count of the peripheral blood, and the uric acid-creatinine ratio in the urine. The present report deals with a study of adrenocortical function based on quantitative determinations in the peripheral blood at intervals before and after operation of two groups of adrenocortical steroids. The two groups are ( a ) 17-hydroxycorticosteroids (17-OHCS), which have in common both an alpha ketol and a hydroxy group in the 17 position and include, among others, compound E (cortisone) and compound F, and ( b ) 17-desoxycorticosteroids (17-desoxy CS), which differ

Treatment of the nephrotic syndrome with corticotropin (ACTH) and cortisone; a four-and-one-half-year survey of results with short-term courses.

The effect of corticotropin (adrenocorticotropic hormone [ACTH]) and cortisone on the acute state of the nephrotic syndrome has been described by a number of workers.* That endogenous corticotropin may be responsible for spontaneous remissions is suggested by diuresis following measles and other infections complicating the disease. Also, in one patient whom we observed during the occurrence of a spontaneous remission, we found an increase in urinary cortins and 17-ketosteroids, a fall in eosinophile count and an increase in uric acidcreatinine ratio immediately preceding the diuresis.4It is the purpose of this communication to try to evaluate the ultimate value of these hormones when given in short-term courses by reviewing our observations in 64 infants and children who had the nephrotic syndrome and who were treated with either corticotropin or cortisone during the past four and one-half years. In accordance with a recently proposed classification,5no effort will be

サリチル酸劑及びキノフエンの副腎皮質ホルモン様作用の検討

The changes of circulating eosinophil counts, urinary excretion of chemocorticoid, and uric acid-creatinine ratio of urine was studied following administration of salicylates and cinophen (cinchophen) in normal and adrenalectomized rats. From the results it is no doubt that sodium salicylate and cinophen stimulates the pituitary-adrenal system, because all of three most important reactions related to adrenal function becomes positive after both of drugs and the reactions are blocked by adrenalectomy.

Thorn test in patients with eosinophilia related to parasitic infection.

The extensive studies on the physiologic and clinical behavior of purified pituitary adrenocorticotropic hormone (ACTH) have made it necessary to develop laboratory procedures which may enable the clinician and investigator to make a safe interpretation of the response of the adrenal cortex to the exogenous pituitary factor. Thorn and his associates 1 used as a criterion of adrenocortical function, the fall of circulating eosinophils and lymphocytes and the increase in urinary excretion of uric acid expressed as a change in uric acid-creatinine ratio. These changes occur when an intact adrenal cortex is stimulated by the injection of 25 mg. of purified ACTH. In subsequent studies the same group of investigators 2 has eliminated the determinations of uric acid and creatinine from their procedures. Obviously other factors, like impaired renal functions, may introduce a source of error in such tests. Even though there is conclusive evidence to show that the number

SODIUM CONCENTRATION OF THERMAL SWEAT IN TREATED AND UNTREATED PATIENTS WITH MENTAL DISEASE

THERE is evidence that treatment of mental disease results in strong stimulation of the adrenal gland; increased secretion of steroid hormones is suggested by studies on the change in lymphocytes and eosinophils in the blood, the uric acid—creatinine ratio and changes in the extracellular fluid volume after shock therapy. 1 In an attempt to gain insight into the activity of the adrenal gland in relation to salt and water metabolism in mental disease and during the course of treatment, it was decided to study the sodium concentration of sweat in patients. MATERIAL AND METHODS Studies were made on 7 nonpsychotic men, 9 nonpsychotic women, 16 psychotic men and 19 psychotic women. The ages ranged from 20 to 76, and the diagnoses were varied (tables 1 and 2). Some of the patients had been ill for long periods, but none was severely deteriorated (table 2). The method of sweat collection was

CHANGES IN URINARY URIC ACID-CREATININE RATIO AFTER ELECTRICALLY INDUCED CONVULSIONS IN MAN

RECENT studies have provided evidence indicating that increased secretion of adrenal cortical steroid hormones occurs in patients given electroconvulsive therapy for mental disease (1–7). Changes in the uric acid-creatinine ratio four hours after the injection of adrenocorticotropic hormone (ACTH) has been suggested as a measure of adrenal cortical function (8) (9) and accordingly it was considered desirable to measure this ratio in patients given electroshock therapy. MATERIAL AND METHODS Fifteen studies were made on 9 women who were given electroconvulsive therapy for mental disease. The ages ranged between 25 and 73 years and the diagnoses varied (Table 1). The patients voided an hour and a half before the treatment; this urine sample was discarded and another sample was obtained immediately before shock was administered. Thereafter, samples were collected four hours after the treatment and whenever possible at the end of two hours also. In addition, some of the patients voided at other times during th...