Abstract
RECENT studies have provided evidence indicating that increased secretion of adrenal cortical steroid hormones occurs in patients given electroconvulsive therapy for mental disease (1–7). Changes in the uric acid-creatinine ratio four hours after the injection of adrenocorticotropic hormone (ACTH) has been suggested as a measure of adrenal cortical function (8) (9) and accordingly it was considered desirable to measure this ratio in patients given electroshock therapy. MATERIAL AND METHODS Fifteen studies were made on 9 women who were given electroconvulsive therapy for mental disease. The ages ranged between 25 and 73 years and the diagnoses varied (Table 1). The patients voided an hour and a half before the treatment; this urine sample was discarded and another sample was obtained immediately before shock was administered. Thereafter, samples were collected four hours after the treatment and whenever possible at the end of two hours also. In addition, some of the patients voided at other times during th...
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