Abstract
ABSTRACT Uric acid excretion was studied in patients with infectious mononucleosis during the acute and convalescent phases and in control groups of patients with nonspecific upper respiratory infections. Fifty-five percent of the patients with acute infectious mononucleosis had serum uric acids greater than 8.0 mg/100 ml. Urinary uric acid excretion and uric acid/creatinine ratios were significantly greater in the acute phase than in the convalescent or control groups, and draws attention to the possible development of uric acid nephropathy. The uric acid-creatinine ratio was greater than 0.60 in 80% of our patients and appears to be a suitable method for detecting increased purine turnover in infectious mononucleosis. This data supports the hypothesis that the hyperuricemia of infectious mononucleosis is due to increased purine turnover.
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