One year ago, we began this special section on innovative labs with the publication of four excellent experiments for use at the undergraduate level [1]. A primary goal for this series is to provide examples of experiments that instructors can incorporate into their own courses. For this special series, we seek manuscripts that describe lab activities based on modern themes presented in an innovative, unique way, preferably using active learning styles such as inquiry-based instruction, discovery-based instruction, problem-based instruction, research-based instruction, etc [2]. In this issue, we continue the special series for 2010 with the four manuscripts listed below. Two of the manuscripts selected (3 and 4) originally used very similar procedures to prepare and isolate proteins, but quite different analysis techniques. These manuscripts have been rewritten by the authors so that they now emphasize unique aspects of the analytical methods they used. We appreciate their efforts in preparing articles in the series that complement one another. We hope instructors and students find the articles to be pedagogically useful. We welcome manuscripts and suggestions for future articles in this series. Genomics and Bioinformatics in Undergraduate Curricula: Contexts for Hybrid Lab/Lecture Courses for Entering and Advanced Science Students. Louise M. Temple (Department of Integrated Science and Technology), Steven G. Cresawn (Department of Biology), and Jonathan D. Monroe (Department of Biology), James Madison University, Harrisonburg, VA 22807. Introducing Proteomics in the Undergraduate Curriculum: A Simple 2D Gel Electrophoresis Exercise with Serum Proteins Thomas D. Kim and Paul A. Craig Department of Chemistry, Rochester Institute of Technology, Rochester, New York, 14623. Expression, Purification, and Analysis of Unknown Translation Factors from E. coli: A Synthesis Approach Justin D. Walter, Peter Littlefield, Scott Delbecq, Gerry Prody, and P. Clint Spiegel Department of Chemistry, Western Washington University, 516 High Street, MS 9150, Bellingham, WA 98225-9150. Purification and Characterization of Taq Polymerase: A 9-Week Biochemistry Laboratory Project for Undergraduate Students Robert M. Bellin, Mary K. Bruno, and Melissa A. Farrow Department of Biology, College of the Holy Cross, 1 College St., Worcester, MA 01610.