University Of Antioquia Research Articles

Erratum to: Automatic detection of discordant outliers via the Ueda’s method

Author details Gosta Ekman Laboratory, Department of Psychology, Stockholm University, Stockholm, Sweden. Arcos-Burgos Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia. Neuroscience Research Group, University of Antioquia, Medellin, Medellin, Colombia. Department of Civil Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.

Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study.

Brain imaging and fluid biomarkers are characterized in children at risk for autosomal dominant Alzheimer disease (ADAD). To characterize and compare structural magnetic resonance imaging (MRI), resting-state and task-dependent functional MRI, and plasma amyloid-β (Aβ) measurements in presenilin 1 (PSEN1) E280A mutation-carrying and noncarrying children with ADAD. Cross-sectional measures of structural and functional MRI and plasma Aβ assays were assessed in 18 PSEN1 E280A carriers and 19 noncarriers aged 9 to 17 years from a Colombian kindred with ADAD. Recruitment and data collection for this study were conducted at the University of Antioquia and the Hospital Pablo Tobon Uribe in Medellín, Colombia, between August 2011 and June 2012. All participants had blood sampling, structural MRI, and functional MRI during associative memory encoding and resting-state and cognitive assessments. Outcome measures included plasma Aβ1-42 concentrations and Aβ1-42:Aβ1-40 ratios, memory encoding-dependent activation changes, resting-state connectivity, and regional gray matter volumes. Structural and functional MRI data were compared using automated brain mapping algorithms and search regions related to AD. Similar to findings in adult mutation carriers, in the later preclinical and clinical stages of ADAD, mutation-carrying children were distinguished from control individuals by significantly higher plasma Aβ1-42 levels (mean [SD]: carriers, 18.8 [5.1] pg/mL and noncarriers, 13.1 [3.2] pg/mL; P < .001) and Aβ1-42:Aβ1-40 ratios (mean [SD]: carriers, 0.32 [0.06] and noncarriers, 0.21 [0.03]; P < .001), as well as less memory encoding task-related deactivation in parietal regions (eg, mean [SD] parameter estimates for the right precuneus were -0.590 [0.50] for noncarriers and -0.087 [0.38] for carriers; P < .005 uncorrected). Unlike carriers in the later stages, mutation-carrying children demonstrated increased functional connectivity of the posterior cingulate cortex with medial temporal lobe regions (mean [SD] parameter estimates were 0.038 [0.070] for noncarriers and 0.190 [0.057] for carriers), as well as greater gray matter volumes in temporal regions (eg, left parahippocampus; P < . 049, corrected for multiple comparisons). Children at genetic risk for ADAD have functional and structural brain changes and abnormal levels of plasma Aβ1-42. The extent to which the underlying brain changes are either neurodegenerative or developmental remains to be determined. This study provides additional information about the earliest known biomarker changes associated with ADAD.

Lo que no se ve, no existe: percepciones sobre cáncer y papilomavirus humano en jóvenes universitarios, Medellín, Colombia, 2014

Objetivo: comprender las percepciones de los estudiantes de pregrado de la Universidad de Antioquia, Colombia, sobre los cánceres de cuello uterino, canal anal, orofaringe y pene, y cómo los relacionan con la infección por PVH. Materiales y métodos: estudio etnográfico, realizado de marzo del 2013 a abril del 2014, participaron 23 mujeres y 14 hombres en ocho grupos de discusión. Sus discursos fueron grabados, transcritos y analizados con el método argumentativo. Resultados: en general, los/as jóvenes relacionaron el cáncer cervicouterino con el PVH, pero no con los tipos de cáncer en canal anal, orofaringe y pene, sobre los cuales tenían poco conocimiento o desconocían. El pensar que las mujeres son las que contraen el cáncer cervical y contagian a los hombres con el PVH no les permitió imaginar que existieran otros cánceres asociados al PVH. Conclusión: las percepciones y la falta de claridad en la relación PVH y otros cánceres, pueden incrementar el riesgo de infección por las prácticas sexuales y en el tiempo aumentar la prevalencia de estos cánceres.

ClassroomQual: a scale for measuring the use-of-classrooms-for-teaching–learning service quality

This study has two purposes: (1) to develop and refine a measure of the quality of the complementary service named ‘use-of-classrooms-for-teaching–learning’ and (2) to contribute to the empirical evidence regarding the dimensions of the complementary service. The design was cross-sectional of development and scale validation. The research methods were based on factor and psychometric analyses. The study was conducted in three phases. In the initial phase, 30 interviews were conducted in order to collect critical incidents. The second phase involved the improvement of items (self-administered questionnaire of 59 items, Cronbach's α, and exploratory factor analyses). Students from Industrial Engineering at the University of Antioquia comprised the sample (n = 290). In the third phase, the confirmatory factor analysis (CFA) was implemented, using Amos 21.0 software. The items that made it through the exploratory stage was 23, classified under 7 latent factors (the initial model in the CFA). Through strategies of re-specification, four more models were arrived at, and finally two models (a 16-item model and a 15-item one), both with seven latent factors, were chosen. These models are two versions of a scale we have called ClassroomQual, which presents satisfactory measures of overall fit, parsimony, reliability, and validity.

Evaluación de conocimientos con exámenes de selección múltiple: ¿tres o cuatro opciones de respuesta? Experiencia con el examen de admisión a posgrados médico-quirúrgicos en la Universidad de Antioquia

Introduction: The aim of this study was to evaluate the effect of reducing the number of response options per question on the psychometric indicators of an exam for admission to postgraduate medical studies, at University of Antioquia, in Medellin, Colombia. Methodology: Application of psychometric assessment indexes from the perspective or two theories: the classical of measurement and the item response, to a test of 70 questions, applied in 2014 to 2.539 candidates. The least frequently chosen distractor was eliminated and randomly replaced by one of the three remaining ones. Results: Only 52.9% of the questions had three functional distractors. No difference was found in the difficulty, discrimination, standard error of measurement, Cronbach's alpha and the coefficient of biserial correlation (classical measurement theory). Also, there was no difference in the extent of item difficulty or ability of people (item response theory). The test with three options retained a good fit. Conclusion: Multiple choice tests with three response options performed as well as their four options counterparts.

Journal Hijacking an Imminent Threat

researchers with the incentive of rapid processing and acceptance of articles within period of time ranging from few days to 2 weeks. Usually journals with not very high impact factors, those with individual publisher with single journal, being published in non English language are being targeted. Well known journals like “Vulfenia Journal” , “Archives des Sciences,”, Emergencias (an emergency medicine journal from Spain), the Journal of the American Medical Association (JAMA), Vitae-Revista (The Official Publication of the Faculty of Pharmaceutical Chemistry at the University of Antioquia, Colombia), Amala (published by the Amala Cancer Research Center in India), TERAPEVTICHESKII ARKHIV (from Russia), Kardiologiya (from Russia) and Revue Scientifique et Technique (published by the World Organization for Animal Health) have been the recent victims of the same [4].

Características de la oclusión en respiradores bucales de 6 a 12 años de la Clínica del Niño en la Facultad de Odontología de la Universidad de Antioquia

Resumen. Introducción: este estudio tuvo como objetivo establecer las característicasde la oclusión en niños respiradores bucales que acuden a la Clínica del Niño de laFacultad de Odontología de la Universidad de Antioquia. Métodos: estudio descriptivotransversal en 100 pacientes respiradores bucales de 6 a 12 años que acudieronpor primera vez a la Clínica del Niño (iv a vii semestre) y sin intervención terapéuticaprevia, identificados a través de una lista de chequeo. Mediante examen clínico,se recogieron variables sociodemográficas, antecedentes médicos, características faciales,hábitos bucales, características de los arcos dentarios, variables relacionadascon la oclusión y presencia de caries e inflamación de las encías. Resultados: más dela mitad de la población evaluada en clase i dental y no presentó competencia labial.Otros hábitos frecuentes fueron la onicofagia y el bruxismo. La línea media dentalinferior desviada con respecto a la línea media facial predomina más en los niños(69%). En cuanto a la mordida cruzada anterior, no se encontraron diferencias marcadasentre niñas y niños, mientras que la mordida abierta anterior se detectó conmayor frecuencia en niños (26%). La forma ovalada de los arcos fue la más predominante(superior: 85%, inferior: 77%), y más de la mitad de los pacientes presentaronpaladar profundo. Se encontraron signos de inflamación gingival en un 80%, y másdel 50% presentó caries dental. Conclusiones: se encontraron características diferencialesen la población evaluada, tanto faciales como en la oclusión, que requierenanálisis más exhaustivos con el fin de ofrecer tratamientos integrales basados en lasnecesidades individuales y colectivas.

Retos de la formación doctoral en derecho en América Latina

In this work I examine the possible challenges fora Law Doctoral Degree in Latin America, considering the socio-cultural and legal context, particularly in Colombia and Argentina, specifically at the School of Law and Political Science at the University of Antioquia, in Colombia, and the School of law and Social Sciences of the National University, Cordoba, Argentina. This article has two parts. In the first part I will present a very general philosophical infrastructure of how I seethe Law degree as an object of know ledge and which ones are some of the most out standing features of the disciplines, concepts, methods and theories that are used to investigate the law. Defending a series of theses that should serve as guidelines to articulate a doctorate degree in law. In the second part, I sketch what could be the basic architecture of a hypothetical doctorate in law.

La ciencia ficción como herramienta pedagógica en un curso de Estudios en Ciencia, Tecnología y Sociedad: descripción de una experiencia docente

Science fiction can be used as a pedagogical aid for the teaching, popularizing, critical reflection and promotion of science and technology. A teaching experience is described in which science fiction stories (novels, short stories, movies and short films) were used exclusively to impart a Science, Technology and Society Studies Course for undergraduate students of the Library Science program, in the Interamerican School of Library Science, Antioquia University, during the first semester of 2014. The course was structured as a reading and writing workshop, supplemented with thematical discussions and exercises. The results were satisfactory, showcasing the students creativity and critical thinking. Several recommendations and resources are presented for other teachers who wish to emulate or adapt the experience.

The collection of the Herpetological Museum of the University of Antioquia (northwestern Colombia).

Northwestern South America harbors one of the richest herpetofauna in the world. The connection among several biogeographic provinces along with climatic and orographic complexity makes this region an important contributor to the Neotropical biodiversity. Despite of this importance, the amphibian and reptile fauna in this area remains largely unknown as few herpetological collections has been made in recent decades. Motivated by this, the Herpetological Museum at the Universidad de Antioquia (Medellín, Colombia) has been increasing the collection in the last 16 years to better understand the herpetofaunal diversity and thus contribute to ecological, systematic, biogeographic and conservation research in the Neotropics. Here, we present the results of this effort and highlight how future collection will impact our understanding of the Neotropical herpetofauna.

Effect of Dexamethasone, LPS, or INFγ on the production of TNFα, IL-12, IL-6, IL-10, CXCL8, CXCL10, and CLC3, by bovine macrophages infected in vitro with Mycobacterium avium paratuberculosis.

Effect of Dexamethasone, LPS, or INFγ on the production of TNFα, IL-12, IL-6, IL-10, CXCL8, CXCL10, and CLC3, by bovine macrophages infected in vitro with Mycobacterium avium paratuberculosis.

Role of astrocytes in neuronal energetic production and its relationship with neurodegeneration

Event Abstract Back to Event Role of astrocytes in neuronal energetic production and its relationship with neurodegeneration Felipe Vargas-Restrepo1, Angelica M. Sabogal-Guaqueta1 and Gloria Patricia Cardona Gomez1* 1 University of Antioquia, Group of Neuroscience of Antioquia, Colombia Astrocytes are specialized glial cells that make important contributions to neuronal support and the blood-brain barrier. This barrier limits the passage of certain fatty acids and lipids to the Central Nervous System (CNS), which the majority of lipids found in this tissue must be synthesized right there. Astrocytes are involved in the conversion and production of fatty acids in the CNS as well as production of lipid messengers that apparently are involved in the activity of neurons and neuroprotective or neurodegenerative processes. For this reason, we review the role of astrocytes in energy production and its relationship to neuronal lipid changes in neuroprotective and neurodegenerative processes. Figure 1 Acknowledgements We want to thank to the Colciencias project # 111565740581. References Amruthesh S.C., Boerschel M.F., McKinney J.S., Willoughby K.A., Ellis E.F. (1993) Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes. J Neurochem. 61, 150-159. Bezzi P., Carmignoto G., Pasti L., Vesce S., Rossi D., Rizzini B.L., et al. (1998) Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature. 391, 281-285. Moore S.A., Yoder E., Murphy S., Dutton G.R., Spector A.A. (1991) Astrocytes, Not Neurons, Produce Docosahexaenoic Acid (22:6ω-3) and Arachidonic Acid (20:4ω-6). Journal of Neurochemistry. 56, 518-524. Posada-Duque R.A., Barreto G.E., Cardona-Gomez G.P. (2014) Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci. 8, 231. doi: 10.3389/fncel.2014.00231. Staub F., Winkler A., Peters J., Goerke U., Kempski O., Baethmann A. (1995) Clearance and metabolism of arachidonic acid by C6 glioma cells and astrocytes. Neurochem Res. 20, 1449-1456. Keywords: Fatty Acids, Astrocytes, neurodegeneration, Neuroprotection, energy production Conference: Latin-American School on glial cells in the diseased brain (IBRO), Bogotá, Colombia, 13 Jul - 17 Jul, 2015. Presentation Type: Poster Presentation Topic: Traumatic and Cerebrovascular diseases Citation: Vargas-Restrepo F, Sabogal-Guaqueta AM and Cardona Gomez G (2015). Role of astrocytes in neuronal energetic production and its relationship with neurodegeneration. Conference Abstract: Latin-American School on glial cells in the diseased brain (IBRO). doi: 10.3389/conf.fncel.2015.35.00006 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Mar 2015; Published Online: 16 May 2015. * Correspondence: Prof. Gloria Patricia Cardona Gomez, University of Antioquia, Group of Neuroscience of Antioquia, Medellin, Antioquia, 05001000, Colombia, patricia.cardona@neurociencias.udea.edu.co Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Felipe Vargas-Restrepo Angelica M Sabogal-Guaqueta Gloria Patricia Cardona Gomez Google Felipe Vargas-Restrepo Angelica M Sabogal-Guaqueta Gloria Patricia Cardona Gomez Google Scholar Felipe Vargas-Restrepo Angelica M Sabogal-Guaqueta Gloria Patricia Cardona Gomez PubMed Felipe Vargas-Restrepo Angelica M Sabogal-Guaqueta Gloria Patricia Cardona Gomez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Antiphospholipid antibodies effect over trophoblast cell function and pharmacological modulation

Event Abstract Back to Event Antiphospholipid antibodies effect over trophoblast cell function and pharmacological modulation Angela M. Alvarez1, Yonhatann Ramírez1, Sebastián Sanmartín2, Udo Markert3 and Angela Cadavid1* 1 University of Antioquia, Colombia 2 University of Valparaíso, Chile 3 University Hospital Jena, Germany Since antiphospholipid antibodies (aPL) are involved in impaired placental development in women with antiphospholipid syndrome (APS), the aim of this study was to determine the effect of aPL on the first trimester trophoblast cell line HTR-8/SVneo function and on the activation of the signal transducer and activator of the transcription 3 (STAT-3) pathway. IgGs purified from women with aPL and clinical manifestations of pregnancy morbidity and/or vascular thrombosis (PM and PM/VT groups), women with pregnancy morbidity without aPL (PM/aPL-), and also healthy women as controls (NHS) were used. First, the aPL binding to trophoblast cells was assessed by immunohistochemistry. Then, trophoblast viability, proliferation and invasion were evaluated. The effects of aspirin, enoxaparin and aspirin-triggered lipoxins (ATL) on antiphospholipid antibody-decreased trophoblast invasion were also evaluated. IgG from women with APS bound strongly to the first trimester extravillous trophoblast cell line HTR-8/SVneo. Reduced cell viability and STAT-3 activation were induced by IgG from women of PM group. On the other hand, the mitochondrial membrane integrity was reduced by IgG from women of PM/VT group, which in contrast induced an increase in proliferating trophoblast cells. Both PM and PM/VT IgG induced a decrease in trophoblast invasion. Aspirin, enoxaparin, and ATL restored the aPL-decreased invasion. Addition of the ATL receptor antagonist Boc-2, reversed the ATL-restored invasion. In conclusion, IgG from women with PM or PM/VT induced different effects on trophoblast cells. Trophoblast invasion was clearly altered but, interestingly, it was restored with enoxaparin, aspirin and, as shown for the first time with ATL. Additionally ATL has a receptor-mediated effect in trophoblast cells as demonstrated by addition of Boc-2. Acknowledgements CODI- Universidad de Antioquia Grant 91515; Sustainability Strategy Grupo Reproducción 2014-2015; Scientific International Cooperation: Colciencias Grant 91567 and CONICYT Grant PCCI 130017; AMA is fellow from Colciencias. Keywords: Antiphospholipid Syndrome, Antiphospholipid antibodies, Trophoblasts, STAT-3, trophoblast invasion Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Autoimmunity Citation: Alvarez AM, Ramírez Y, Sanmartín S, Markert U and Cadavid A (2015). Antiphospholipid antibodies effect over trophoblast cell function and pharmacological modulation. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00228 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 May 2015; Published Online: 14 Sep 2015. * Correspondence: MD, PhD. Angela Cadavid, University of Antioquia, Medellín, Colombia, angela.cadavid@udea.edu.co Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Angela M Alvarez Yonhatann Ramírez Sebastián Sanmartín Udo Markert Angela Cadavid Google Angela M Alvarez Yonhatann Ramírez Sebastián Sanmartín Udo Markert Angela Cadavid Google Scholar Angela M Alvarez Yonhatann Ramírez Sebastián Sanmartín Udo Markert Angela Cadavid PubMed Angela M Alvarez Yonhatann Ramírez Sebastián Sanmartín Udo Markert Angela Cadavid Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Vitamin D role in Dengue virus replication and the inflammatory response in human macrophages.

Vitamin D role in Dengue virus replication and the inflammatory response in human macrophages.

Risk factors for eczema, in a tropical environment. Presentation of the TECCEMA cohort.

Event Abstract Back to Event Risk factors for eczema, in a tropical environment. Presentation of the TECCEMA cohort. Jorge Sánchez1, 2, 3*, Ricardo Cardona1 and Andres Sánchez2, 3, 4, 5 1 Group of Clinical and Experimental Allergy (GACE), IPS Universitaria, University of Antioquia, Medicine Department, Colombia 2 Group of Experimental Allergy and Immunogenetics, Institute for Immunological Research, University of Cartagena, Colombia 3 Foundation for the Development of Medical and Biological Sciences (FUNDEMEB), Colombia 4 University of Magdalena, Colombia 5 Medicine Department, Corporación Universitaria Rafael Nuñez, Colombia BACKGROUND: Eczema is a frequent disease especially in children in the worldwide. Different risk factors like allergen sensitization has been identify but the role of this and others factors in populations from tropical region, are unknown. OBJECTIVE: To present the TECCEMA cohort study (Tropical Environmental Control for Chronic Eczema and Molecular Assessment) designed to investigate molecular and environmental risk factors for eczema in a tropical environment. METHODS: Patients with diagnosis of eczema who consulted for public and private health centers from Aburra Valley were screened for eligibility. 433 patients were included at baseline and biological samples were collected during a follow-up for 36 months for immunological testing. Severity (SCORAD), quality of life (DLQI) and other clinical information was collected using different validated questionnaires. RESULTS: 433 patients were included and the mean age was 8 (3-41). 60% had an income under 250 dollars. According to the SCORAD, 40%/37%/23% patients had mild/moderate/severe symptoms. Most of patients with early beginning (before 3 year) of eczema had a reduction in severity during follow-up (70%). However, patients with early beginning and high SCORAD (>40) and polisensitization before 3 years had a lower response to pharmacotherapy and a lower rate of remission [aOR 3.12 (95%CI 1.80-4.75), p = 0.001]. Family history of eczema, (parents) [aOR 2.03 (95%CI 1.64-3.47), p = 0.01] and early food allergy [aOR 1.83 (95%CI 1.21-3.74), p = 0.03] were independent risk factors. We observed a higher frequency of exacerbations with periods of high temperatures (>28°C) and relative humidity (>80%) [aOR 2.83 (95%CI 1.71-5.74), p = 0.002]. CONCLUSIONS: We create a cohort of patients with eczema and we identified some risk factors for severe dermatitis in the tropical region. With the clinical follow-up and the collection of biological samples, we will contribute to understand how particular characteristics of tropical environment could interact in the beginning and development of eczema. Acknowledgements Acknowledgment: In memorial of Elizabeth Lopez who contributed to the study design and recruitment of patients. This proyect was support for the University of Antioquia and the University of Cartagena. There are not conflict of interest. Keywords: Dermatitis, Eczema, allergy, cohort, SCORAD, tropical Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Oral Presentation Topic: Allergy Citation: Sánchez J, Cardona R and Sánchez A (2015). Risk factors for eczema, in a tropical environment. Presentation of the TECCEMA cohort.. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00291 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 06 Apr 2015; Published Online: 15 Sep 2015. * Correspondence: Dr. Jorge Sánchez, Group of Clinical and Experimental Allergy (GACE), IPS Universitaria, University of Antioquia, Medicine Department, Medellín, antioquia, 05001000, Colombia, jotamsc@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jorge Sánchez Ricardo Cardona Andres Sánchez Google Jorge Sánchez Ricardo Cardona Andres Sánchez Google Scholar Jorge Sánchez Ricardo Cardona Andres Sánchez PubMed Jorge Sánchez Ricardo Cardona Andres Sánchez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Diagnostic and treatment of allergy diseases; from the molecular assessment to the clinical practice

Event Abstract Back to Event Diagnostic and treatment of allergy diseases; from the molecular assessment to the clinical practice Jorge Sánchez1* 1 Professor, University of Antioquia, Colombia BACKGROUND: Advances in biotechnology and genetic engineering have allowed better understanding of the causes of different allergies. The isolation and cloning of proteins has allowed to identify the most relevant allergens and explain the cross-reactivity between different sources. At the same time, this knowledge has enabled the creation treatments taking into account specific targets, which has improved the effectiveness of therapies and safety. OBJECTIVE: To present the clinical impact of advance in biotechnology in allergy diseases. METHODS: Using four clinical examples, we present different aspect of allergic diseases and how the better understanding of allergens components as part of the physiopathology of atopic diseases, could result in a better diagnostic and prognostic for the treatment. The four diseases present are food allergy, rhinitis, urticaria and dermatitis. RESULTS: Allergy to cow's milk: Depending allergens to which the patient is sensitized and concentration, you can define the prognosis of the patient develop a tolerance that allows you to overcome the disease or else your persistence. At the same time, can be determined if the patient can tolerate the replacement of other foods soy or rice. Respiratory diseases: identification of the causative allergens process allows the establishment of specific measures of avoidance. Furthermore, the onset of early immunotherapy in patients with rhinitis decreases the risk of developing asthma. Urticaria: Urticaria Have different etiologies and in most cases are not IgE mediated. However different factors like autorreactivity, some foods, cold, water and other physical factors, Could Be triggers. Some in vivo and in vitro test permit the identification of the principal factors and the Implementation of specific treatment. Dermatitis: most patients with dermatitis had a good clinical response with topical treatment using emollients and steroids. However, Th1 and Th2 response are present in some severe cases of dermatitis. Identification of IgE to auto-antigens could predict the clinical response of patients and the necessity of systemic treatment with immunosupressors. CONCLUSIONS: The progress in the understanding of allergic diseases have been consequence for the growing knowledge in biotechnology and other sciences fields. This progress have results in better diagnostic techniques and managements for allergic diseases. Acknowledgements Acknowledgment: In memorial of Elizabeth Lopez who contributed to the study design and recruitment of patients. Keywords: allergy, Immunotherapy, Milk, Asthma, Rhinitis Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Oral Presentation Topic: Allergy Citation: Sánchez J (2015). Diagnostic and treatment of allergy diseases; from the molecular assessment to the clinical practice. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00275 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 May 2015; Published Online: 14 Sep 2015. * Correspondence: Dr. Jorge Sánchez, Professor, University of Antioquia, Medellín, antioquia, Colombia, jotamsc@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jorge Sánchez Google Jorge Sánchez Google Scholar Jorge Sánchez PubMed Jorge Sánchez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

ASTROCYTES IN THE NEUROPROTECTION AFTER BRAIN STROKE

Event Abstract Back to Event ASTROCYTES IN THE NEUROPROTECTION AFTER BRAIN STROKE Andrea Del Pilar Becerra Calixto1 and Gloria Patricia Cardona Gomez1* 1 University of Antioquia, Group of Neuroscience of Antioquia, Colombia Astrocytes are specialized glial cells of the nervous system, which have multiple homeostatic functions for the survival and maintenance of the neurovascular unit. It has been shown that astrocytes have critical role in the dynamics pro survival conferring neuroprotective, angiogenic, immunomodulatory, neurogenic, antioxidants and regulatory synapse functions (Shen et al 2012; Gimsa et al 2013; Proschel et al 2014); making them excellent candidates as the source of neuroprotection and neurorestauration of tissue affected by events ischemia and / or reperfusion. However, these cells also may be involved in negative responses such as reactive astrocytes and glial scar under chronic excitotoxic responses generated by these events. To know what are the key points in the pro and anti-survival responses of astrocytes, would allow use them as targets in cellular therapies. This review has aim to study the mechanisms for neuroprotection in these cells (Posada-Duque et al submitted), which would make them targets of cell therapy, through of inducing regeneration, such as vehicle for corrective molecular systems and trigger endogenous cellular events that can recover the tissue homeostasis, which is lost after progressive damage. Figure 1 Acknowledgements The research reported in this publication was supported by CODI # 214-970 and Colciencias project #111554531400. References Gims, U., Mitchison, N. A., Brunner-Weinzierl, M. C. (2013) Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation. Mediators Inflamm 2013, 320519. doi: 10.1155/2013/320519. Posada-Duque, R., Palacio-Castañeda, V., Cardona-Gómez, GP. CDK5 knockdown Astrocytes are trophic source for neuronal protection through Rac1. Submitted. Proschel, C., Stripay, J. L., Shih, C. H., Munger, J. C., Noble, M. D. (2014) Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons. EMBO Mol Med 6, 504-518. doi:10.1002/emmm.201302878. Shen Y. , Sun, A., Wang, Y., Cha, D., Wang, H., Wang, F., Feng, L., Fang, S. (2012) Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation 9, 254 doi:10.1186/1742-2094-9-254. Keywords: Astrocytes, cell therapy, Neuroprotection, cerebral ischemia, excitotoxicity Conference: Latin-American School on glial cells in the diseased brain (IBRO), Bogotá, Colombia, 13 Jul - 17 Jul, 2015. Presentation Type: Oral Presentation Topic: Traumatic and Cerebrovascular diseases Citation: Becerra Calixto A and Cardona Gomez G (2015). ASTROCYTES IN THE NEUROPROTECTION AFTER BRAIN STROKE. Conference Abstract: Latin-American School on glial cells in the diseased brain (IBRO). doi: 10.3389/conf.fncel.2015.35.00007 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Mar 2015; Published Online: 16 May 2015. * Correspondence: Prof. Gloria Patricia Cardona Gomez, University of Antioquia, Group of Neuroscience of Antioquia, Medellin, Antioquia, 05001000, Colombia, patricia.cardona@neurociencias.udea.edu.co Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez Google Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez Google Scholar Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez PubMed Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Establishing Composite Cognitive Endpoints for Use in Preclinical Alzheimer's Disease Trials.

Establishing Composite Cognitive Endpoints for Use in Preclinical Alzheimer's Disease Trials.

Searching for prognostic factors in Common Variable Immunodeficiency based on epidemiological and immunological parameters

Searching for prognostic factors in Common Variable Immunodeficiency based on epidemiological and immunological parameters

EL HIP HOP: UNA PRÁCTICA CORPORAL QUE TERRITORIALIZA LA CIUDAD DE MEDELLÍN

Este artículo es un producto asociado a la investigación La apropiación de las prácticas corporales urbanas de danza en la juventud de la ciudad de Medellín – Comuna 13 (Col.), realizada en la maestría en Motricidad y Desarrollo Humano de la Universidad de Antioquia. En él se indaga, a través de una etnografía urbana, sobre la manera como los jóvenes de la ciudad configuran un territorio cultural por medio de la práctica del hip hop. Arte juvenil que se desarrolla en medio de las tensiones que se producen entre los jóvenes, las instituciones, los pobladores y las organizaciones legales e ilegales.