ASTROCYTES IN THE NEUROPROTECTION AFTER BRAIN STROKE

Abstract

Event Abstract Back to Event ASTROCYTES IN THE NEUROPROTECTION AFTER BRAIN STROKE Andrea Del Pilar Becerra Calixto1 and Gloria Patricia Cardona Gomez1* 1 University of Antioquia, Group of Neuroscience of Antioquia, Colombia Astrocytes are specialized glial cells of the nervous system, which have multiple homeostatic functions for the survival and maintenance of the neurovascular unit. It has been shown that astrocytes have critical role in the dynamics pro survival conferring neuroprotective, angiogenic, immunomodulatory, neurogenic, antioxidants and regulatory synapse functions (Shen et al 2012; Gimsa et al 2013; Proschel et al 2014); making them excellent candidates as the source of neuroprotection and neurorestauration of tissue affected by events ischemia and / or reperfusion. However, these cells also may be involved in negative responses such as reactive astrocytes and glial scar under chronic excitotoxic responses generated by these events. To know what are the key points in the pro and anti-survival responses of astrocytes, would allow use them as targets in cellular therapies. This review has aim to study the mechanisms for neuroprotection in these cells (Posada-Duque et al submitted), which would make them targets of cell therapy, through of inducing regeneration, such as vehicle for corrective molecular systems and trigger endogenous cellular events that can recover the tissue homeostasis, which is lost after progressive damage. Figure 1 Acknowledgements The research reported in this publication was supported by CODI # 214-970 and Colciencias project #111554531400. References Gims, U., Mitchison, N. A., Brunner-Weinzierl, M. C. (2013) Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation. Mediators Inflamm 2013, 320519. doi: 10.1155/2013/320519. Posada-Duque, R., Palacio-Castañeda, V., Cardona-Gómez, GP. CDK5 knockdown Astrocytes are trophic source for neuronal protection through Rac1. Submitted. Proschel, C., Stripay, J. L., Shih, C. H., Munger, J. C., Noble, M. D. (2014) Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons. EMBO Mol Med 6, 504-518. doi:10.1002/emmm.201302878. Shen Y. , Sun, A., Wang, Y., Cha, D., Wang, H., Wang, F., Feng, L., Fang, S. (2012) Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation 9, 254 doi:10.1186/1742-2094-9-254. Keywords: Astrocytes, cell therapy, Neuroprotection, cerebral ischemia, excitotoxicity Conference: Latin-American School on glial cells in the diseased brain (IBRO), Bogotá, Colombia, 13 Jul - 17 Jul, 2015. Presentation Type: Oral Presentation Topic: Traumatic and Cerebrovascular diseases Citation: Becerra Calixto A and Cardona Gomez G (2015). ASTROCYTES IN THE NEUROPROTECTION AFTER BRAIN STROKE. Conference Abstract: Latin-American School on glial cells in the diseased brain (IBRO). doi: 10.3389/conf.fncel.2015.35.00007 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Mar 2015; Published Online: 16 May 2015. * Correspondence: Prof. Gloria Patricia Cardona Gomez, University of Antioquia, Group of Neuroscience of Antioquia, Medellin, Antioquia, 05001000, Colombia, patricia.cardona@neurociencias.udea.edu.co Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez Google Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez Google Scholar Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez PubMed Andrea Del Pilar Becerra Calixto Gloria Patricia Cardona Gomez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.