Anomalous heat transfer intensification in turbulent separated air flow over a long groove of moderate depth made in a plate inclined at an angle of 45°to the freestream is revealed both experimentally and numerically. The region under investigation includes a rectangle heated to 100°C by saturated water vapor. The Reynolds number varied from 103to 3×104. Using the gradient heatmetry the twofold increase, as compared with the case of a flat plate, of the heat transfer coefficient on the groove bottom is established at the Reynolds number Re = 3×104. The relative Nusselt number in different regions of the groove is determined both in the physical experiment and in the RANS calculations with the application of multiblock computational technologies and the SST model in the VP2/3 software package. The results are in good agreement in the turbulent flow regime at Re = (5, 10, and 30) ×103.