This paper presents a novel low power and high speed 4-bit comparator extendable to 64-bits using floating-gate MOSFET (FGMOS). Here, we have exploited the unique feature of FGMOS wherein the effective voltage at its floating-gate is the weighted sum of many input voltages which are capacitively coupled to the floating-gate. The performance of proposed 4-bit comparator circuit has been compared with other comparator circuits designed using CMOS, transmission gate (TG), pass transistor logic (PTL) and gate diffusion input (GDI) technique. The proposed FGMOS based 4-bit comparator have shown remarkable performance in terms of transistor count, speed, power dissipation and power delay product besides full swing at the output in comparison to the existing comparator designs available in literature. Thus the proposed circuit can be viable option for high speed and low power applications. The performance of the proposed FGMOS based 4-bit comparator has been verified through OrCAD PSpice simulations through circuit file/schematics using level 7 parameters obtained from TSMC in 0.13μm technology with the supply voltage of 1V.