Objectives: This study investigates concentrations of toxic metals, Lead and Cadmium in water, sediments and fish organs (muscle, liver and gill). Collected from Aden coast, gulf of Aden in Yemen. Water samples and sediment were taken from nine locations. Methods: Four fish species were collected (Lethrinus mahsena; Epinephelus areolatus; Thunnus tonggol and Sphyraena jello) were collected from the local commercial fishermen of Aden city during winter 2011, Summer 2012 and winter 2013. Results: Lead concentration in sea water is 0.045-0.055 mg/l and Lead concentration in Sediment 33.512-35.726 µg/g dry wt., Cadmium concentration in sea water 0.006-0.010 mg/l, Cadmium concentration in sediment 1.944-2.004 µg/g dry wt., lead concentration is the highest in most fish gill samples 0.047-0.727 µg/g dry wt., where as in muscles is the lowest 0.020-0.116 µg/g dry wt., and in liver was 0.038- 0.267 µg/g dry wt. Cadmium concentration is the highest in most fish gill samples 0.033-0.609 µg/g dry wt., where as in muscles is the lowest 0.018- 0.073 µg/g dry wt., and in liver was 0.028-0.209 µg/g dry wt. Conclusion: By comparing the results obtained with other data obtained from the local and international studies, in addition to, comparing the results standard levels of these metals contaminated and adopted internationally and domestically and the pollution levels in Yemen is currently within the lower limits of pollution. Peer Review History: Received 22 November 2017; Revised 8 January; Accepted 11 January, Available online 15 January 2018 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Nicola Micale, University of Messina, Italy, nmicale@unime.it Dr. Omid Gholami, Sabzevar University of Medical Sciences, Iran, omidghphd@gmail.com Similar Articles: ANALYTICAL ENVIRONMENTAL STUDY ON THE POLLUTION EFFECT OF HEAVY METALS IN SOME TYPES OF THE FISH IN YEMEN