Event Abstract Back to Event Functionalization of titanium implant surface for improving osteointegration Quang Van Le1, Mathilde Giraudel2, Geneviève Pourroy1, Leandro Jacomine2, Géraldine Koenig3, Caroline Fischer3, Fabienne Perrin Schmitt3, 4 and Adele Carradò1 1 Université de Strasbourg, IPCMS UMR7504 CNRS, France 2 Université de Strasbourg, ICS UPR22 CNRS, France 3 Université de Strasbourg, INSERM UMRS-1121 BioMatériaux et Bioingénierie,Faculté de Médecine, France 4 Université de Strasbourg, LBBM-NHC, France Several methods were developed by physical or chemical methods to deposit calcium phosphate (Ca-P) or a mixture of Ca-P and titanium oxide on Titanium (Ti) and its alloys. We present a designed multilayer system made by chimie douce and we demonstrate its bioactivity. The process is based on successive chemical and thermal treatments of Ti, that lead to the formation of an intermediate sodium titanate layer, identified as Na2Ti9O19 according to X-ray diffraction [1]. CaP was deposited on the sodium titanate layer by dip- or spin-coating. Scanning electron microscopy of superficial layers showed a sodium titanate micro-structure with pore sizes ranging from 0.1 to 1 µm. Scratch tests demonstrated the strength of the bonding to the Ti support, as no delamination occurred. Three different cell-types were initially tested: fibroblasts (NIH-3T3), epithelial cells (SW480), and preosteoblasts (MC3T3-E1). Additional investigations with MC3T3-E1 cells have shown that bioactive CaP coated surfaces increase both the growth rate and differentiation of preosteoblast to osteoblast (compared to bioactive sodium titanate supports). CaP coated supports boosted the cell growth rate in culture, and favored a 3D cellular network organization. Increased expression of regulatory networks favoring cell growth, energy metabolism, early extracellular matrix deposition, and early osteoblastic lineage commitment confirmed CaP coated supports favor successful osseointegration. A comparison with commercial implants has been done; In vivo tests performed on dogs will be presented. Mechanical and histological results will be given. To summarize, our designed multilayer system is economical and simple without any adhesiveness failures, and appears to be a promising strategy to generate long lasting dental implants.