In this work, we propose a highly efficient thermoacoustic energy converter based on the concept of Fano-based bistable systems. The proposed device, in its simplest version consists of a bilayer polymeric cylinder with harder core and softer and thinner shell. The heat source enforced at the core-shell interface induces thermo-mechanical stress fields. The stress field causes the occurrence of wrinkling patterns in the shell and the release of acoustic energy by a snap-through-buckling mechanism. We show that, when the shell is acoustically resonant at a specific frequency, the synergetic interplay of snap-through and Fano-resonances is capable of producing high amplitude and long-lasting pressure oscillations. In other words, under specifics conditions, the synergetic interaction between wrinkling instabilities and Fano resonance is able to extract mechanical energy from the heat source. The efficiency of the system in converting heat-into-work under resonant conditions is at least 6 times higher than that out of resonance. Notably, for a temperature difference of 1 K between the heat source (the hot thermal reservoir beneath the resonant shell) and the surrounding water (the cold thermal reservoir above the resonant shell), the system may reach a conversion efficiency above 70% of the theoretical Carnot efficiency. The so-generated mechanical oscillations can be converted in electrical energy for instance by using sound-to-energy converting systems such as conventional loudspeakers. The characteristics of the heat source have been selected to be representative of low-grade thermal sources (e.g. waste-heat, in particular intermittent sources) abundantly available in natural, and industrial contexts. Importantly, the systems may be adapted to many different geometries spanning from the proposed core-shell cylinders in which the heat source can be either inside the tube (for instance an exhaust gas/liquid outlet) or outside the tube, to plates (like a solar panel system).