Battery thermal management system (BTMS) can maintain the operating temperature and temperature difference of Lithium-ion batteries (LiBs) within the ideal range. In this paper, three kinds of liquid cooling plates with mesh structures (LCP-MSs) were proposed, and they were compared with the LCP with straight channel (LCP-SC). The results show that the LCP-MSs can effectively improve the temperature uniformity of the LiB and reduce the heat concentration. Among the three proposed LCP-MSs, the LCP with drop-shaped deflectors (LCP-DD) is particularly outstanding in reducing the pressure drop (∆P) of coolant. At the same time, in terms of cooling performance, the gap between LCP-DD and the other two LCP-MSs is very small. To further study the cooling performance and ∆P of LCP-DD, structural parameters, number of deflectors, layout of deflectors, and inlet velocity were investigated. The results show that the heat dissipation performance of LCP-DD was improved with the increase of the deflector size/number and the inlet velocity, while ∆P shows an increasing trend. Finally, the orthogonal test was carried out to optimize the design of the proposed LCP-DD. The optimal solution can control the maximum temperature, maximum temperature difference and pressure drop at 301.3 K, 3.1 K, and 251 Pa, respectively.