With the increase of CPU operating frequency, the data that the computer deals with will increase relatively. We need faster memory to deal with the data transmitted when designing product. Original memory is only access data in the rising time, changed into assess data in rising time and falling time; this is DDR SDRAM (Double Data Rate Synchronous Dynamic Random Access Memory). When the speed of access data still can't keep up with the speed of CPU, we improve DDR SDRAM. Upgrade 2 bits Pre-fetch of DDR DRAM to 4 bits Pre-fetch, this is DDR2 SDRAM. In this paper, we propose the method and standard of PCB layout of DDR2 SDRAM. In the mean time, we take demand for Timing standard of a DDR2 SDRAM as an example, to design PCB layout of DDR2 SDRAM module. And measure its address signals, data signals and control signals with oscilloscope, according to the time sequence of pulse movements of synchronous. In DDR2 SDRAM module that pulse movements of synchronous controls, when the pulse was transferred to the status, Set-up Time and Hold Time of address signals, data signals and control signals should all keep its standard. In this article gives an example the PCB wiring, its presents Set-up Time and Hold Time all conform to the standard. Sufficiently proof the PCB wiring method and the criterion of DDR2 SDRAM module may do for the industrial related design reference.