The present study examines the intricate dynamics of flow velocities, temperature distribution, and concentration profiles within Casson hybrid nanofluids as they traverse an unsteady vertical rotating cone, accounting for suction velocity and slip effects. The investigation dissects shear stress rates and thermal and mass transfer rates, leveraging the computational power of MATLAB's bvp4c method to tackle the problem's high non-linearity. The research extends to explore the interplay of magnetic parameters, radiation parameters, thermophoresis, Brownian motion, and chemical reactions in the context of Casson hybrid nanofluid flow over an unsteady vertical rotating cone. The incorporation of velocity slip effects and suction velocity emerges as a pivotal catalyst, elevating the rates of heat and mass transfer. Notably, the findings reveal a substantial enhancement in tangential and azimuthal skin friction by 52 % and 34 %, respectively, when transitioning from Casson nanofluid to Casson hybrid nanofluid. Most strikingly, the rate of heat transfer experiences a remarkable surge of 125 % when Casson hybrid nanofluid supplants Casson nanofluid. This research opens up exciting possibilities for improving heat and mass transfer in various industrial applications, making it a compelling contribution to the field of fluid dynamics and nanofluid research.