To report on our single institution survival and toxicity outcomes for pancreatic cancer patients treated with varying radiation dose fractionation and chemotherapy dose schedules. A total of 99 pancreatic cancer patients treated between 2003 and 2015 were evaluated for overall survival (OS) and treatment related complications. Variables in estimating Cox proportional hazards and OS included age, concurrent chemotherapy, PTV dose, group stage, pre-treatment chemotherapy, post-treatment chemotherapy, surgery, race, sex, and RT-technique. Prescribed radiation doses ranged from 25-60 Gy in 1.8-5.0 Gy/day. The population included 47 neoadjuvant pancreatic adenocarcinoma patients and 32 definitive patients who received concurrent capecitabine and varying post-treatment chemotherapy regimens, and 20 adjuvant patients with varying treatment parameters. Severe acute toxicities requiring treatment discontinuation were also compared to clinical variables. Median OS was 7.8, 12.2, and 20 months in the definitive, neoadjuvant, and adjuvant treatment groups respectively, p<0.001. OS was statistically improved in patients with lower overall group stage, with a median OS of 22, 14.2, 9.5, and 6 months, respectively, for stage 1-2a, 2b, 3, and 4 patients. OS was also improved in patients who underwent a successful surgical resection, with a median OS of 20.5, 9.0, and 14 months for patients undergoing surgical resection, no surgery or an aborted surgical procedure, respectively (p<0.001). In the 32 definitive patients, 3-year OS was 8%, with post-treatment chemotherapy being significant for improved OS (HR=0.43, p=0.01); 6 month OS was 93% vs 35% between patients who did versus did not receive post-treatment chemotherapy. In the neoadjuvant patients, 3-year OS was 14% with the addition of post-CRT chemotherapy (HR=0.81, p=0.04) improving OS. In the adjuvant patients, the 3 year OS was 30%; 17 did not receive post-operative chemotherapy while 23 received gemcitabine-based post-treatment chemotherapy with no significant difference in OS (p=0.3). On multivariate analysis group stage (p=0.005, HR= 1.02) and receipt of chemotherapy either pre (p=0.009, HR=0.116) or post-operatively (p=0.017, HR=0.393) maintained significance. For toxicity, 20 complications were identified that required aborting treatment and hospitalization: 6 sepsis / infection, 10 intractable nausea/vomiting/diarrhea, 2 grade-3 bowel obstruction, 1 bowel perforation resulting in death, and 1 severe weight loss. No variables were significant predictors of toxicity. We show large survival variations as a function of treatment intent and post-CRT chemotherapy regimens in pancreatic adenocarcinoma patients.