In the electric power industry of Ukraine, the main system-forming objects are power transmission lines and substations with 330(220) kV switchgear. The most powerful sources of danger at substations are short circuits on the busbars, a direct lightning strike or the operation of overvoltage limiters and arresters.The purpose of the article is to develop a method for determining the resistance of the grounding system of substations with open switchgear 330(220) kV, aimed at increasing accuracy, taking into account the most influential independent factors. The provisions of the theory of experiment planning, the theory of electric circuits, mathematical modeling in the package Grounding 1.0, LiGro and Microsoft Excel were used to conduct the research. In the paper, a comparative analysis of the known formulas for determining the resistance of the grounding system is carried out: the formula of the GOST 12.1.30-81 standard, Ohlendorf-Laurant, Laurent and Neumann, Schwartz, Sverak formulas, as well as the formula of the international standard IEEE Std 80-2013. The results of multifactorial experiments to determine the dependence of the resistance of the grounding system on its area, the size of the grid cell, the perimeter of the cross-section of the grounding, the equivalent specific resistance of the soil, the short-circuit current and the depth of the grid location are given. A graphical comparison of the results of determining the resistance according to the considered formulas was carried out. In the paper, the method of determining the parameters of grounding system of 330(220) kV substations was further developed, aimed at ensuring standardized values of the resistance of the grounding system and the ground potential rise using formulas obtained from the results of multifactorial experiments. The results obtained in the work will make it possible to reduce the probability of damage to the insulation of 6-10 kV cables, as well as cables of secondary circuits from low-frequency and high-frequency (pulse) voltages when large currents flow into the grounding system in the mode of a single-phase short-circuit to the ground in electrical grid with a grounded neutral. References 9, tables 2, figures 6.