Translation Studies Research Articles

Perspectives on Eco-Translation in Diane Ackerman ("The Zookeeper’s Wife") and Kapka Kassabova ("Border: A Journey to the Edge of Europe")

The present article takes into account a current trend in the translation studies that reconsiders anthropocentric thinking about translation – as Michael Cronin, one of the leading theoreticians of this movement believes, communication systems have to be made effective against the threatening prospects of an imminent ecological crisis. Central to this expanded vision of translation is the idea that communication is not the exclusive “property” of humanity, but a natural means of interaction that characterizes the lives and being of all planetary forms of existence (including landscapes and geological sites). In other words, the Earth itself is held together by impulses of verbal and non-verbal communication, and human beings are just members of this infinitely extended, but effectively operating communicative space that Cronin refers to as “tradosphere”. While this is just the beginning of a challenging, exciting and meaningful re-routing of the conventional modes of thinking about translation, I aim to explore how this planetary consciousness can be employed as a critical instrument in reading narratives of suffering and survival. It is in such survival stories that human integrity is tested both psychologically and physically as physical menace strips human characters of their cultural identities and relocates them in the immense network of cross-species communication.

Features of translation of similes in literary translation (based on J. Rowling's novel “Harry Potter and the Philosopher's Stone”)

The scientific paper analyzes the transmission of similes in literary translation from English into Kazakh. On the example of the literary translation of J. Rowling “Harry Potter and the Philosopher's Stone”, the problems of using similes in the source language and their translation to the target language are considered. Based on the theoretical work of domestic and foreign scientists who studied similes, the problems of the features of their application, classification and translation are studied. At the same time, the features of literary translation and its importance in the preservation and dissemination of cultural heritage were considered. In the course of the study, the problem of preserving the style, tone, meaning and spirit of similes when translating similes structures from the source language into the target language was discussed. Various ways of translating similes were also discussed, taking into account cultural differences and characteristics of the target audience. The problems faced by translators, such as the gap between linguistic forms and cultural contexts, are studied. Summarizing the article, it was concluded that the study of literary translation is one of the most pressing issues for preserving linguistic and cultural diversity in world literature and providing Kazakh-speaking readers with the opportunity to enjoy great works.

Organometallic Oxidative Addition Complexes for S-Arylation of Free Cysteines.

Development of bioconjugation strategies to efficiently modify biomolecules is of key importance for fundamental and translational scientific studies. Cysteine S-arylation is an approach which is becoming more popular due to generally rapid kinetics and high chemoselectivity, as well as the strong covalently bonded S-aryl linkage created in these processes. Organometallic approaches to cysteine S-arylation have been explored that feature many advantages compared to their more traditional organic counterparts. In this Viewpoint, progress in the use of Au(III) and Pd(II) oxidative addition (OA) complexes for stoichiometric cysteine S-arylation is presented and discussed. A focus is placed on understanding the rapid kinetics of these reactions under mild conditions, as well as the ability to generate biomolecular heterostructures. Potential avenues for further exploration are addressed and usefulness of these methods to the practitioner are emphasized in the discussion.

ANALYSIS OF FUNCTIONAL SPEECH ADAPTATION STRATEGIES IN MILITARY TRANSLATION

The research is focused on the aspect of functional speech adaptation of language interpreters who are gaining practical experience at the initial stage in the sphere of foreign-language military-professional communication and paying special attention to the search for original speech strategies to achieve the targets of the translation process in the most efficient way. The critical objective of the article is to theorize the functional speech adaptation and underscore the need and importance to develop interpreters’ unique creative strategies in the process of their adaptive professional maturation for the due carrying out of normal and special translation tasks under the conditions of operational military activities abroad. A detailed review of the scientific sources is carried out concerning research into definitions of linguistic terms such as: “adaptation,” “speech adaptation,” “speech strategies.” The author’s definition of the core of the term “Functional speech adaptation” is given and its main differences are outlined versus the definitions of the linguistic categories “adaptation” and “pragmatic adaptation” proposed by Russian linguistic theorists earlier. The most effective strategies for interpreting are reviewed, viz.: implementation of an interpreter’s anticipation, a strategy for target text forming from the ground of precision information, and a strategy for source text segmentation into minimal translation cells. The study applies the methods of definitional analysis, comparative analysis of theoretical principles with their generalization, theoretical synthesis of the concepts’ definitions, linguistic description method and linguistic modeling. The results of the conducted research make a significant contribution to studying functional speech adaptation of military interpreters in the implementation of interpreting and translation tasks on the foreign military sub-languages material. Moreover, the results of the study can be used for future research purposes of translation studies, theoretical and applied linguistics.

Ontological and philosophical basis of the causal status of ethnopsychological idiosyncrasy in translation/interpretation

The causal status of the phenomenon of ethnopsychological idiosyncrasy is considered in the article in relation to the process of translation in the format of activity ontology. In translation studies, activity ontology uses not only comparison of idiomatic units and structures, but also, for research purposes, draws on textual, cultural, psychological, philosophical, pragmatic, cognitive and other aspects and phenomena which underlie translation process as a unique manifestation of interlingual and intercultural mediation. The activity paradigm opened up new prospects for studying fundamental problems of the translation theory. Among these problems are factors (determinants) of an adequate translation that are prerequisites of a translator’s work. Ethnopsychological idiosyncrasy, the concepts world picture and closely connected world idiomatic picture are considered from philosophical, and linguistic perspectives as well as from the point of view of translation theory.The article proves the causal status of ethnopsychological idiosyncrasy as one of the most important factors determining translation activity. In order not to “lose yourself ” in the idiomatic picture of the target language, which is conditio sine qua non for an adequate translation, translators should possess professional skills to overcome conceptual stereotypes and peculiarities of the ethnic and psychological idiosyncrasy in the source language. If it doesn’t happen, translations are perceived as not quite natural and therefore are not fully adequate.The differences in ethnic and psychological peculiarities in the communities, which enter into bilingual communication, form an ethnic and psychological differential, which should be neutralized during translation.The author established certain manifestations of the Spanish ethnic and psychological idiosyncrasy relevant for the translator’s communicative activity in the Spanish-Russian idiomatic combination.

A novel weight-drop closed head focal traumatic brain injury: A candidate to translational studies?

Traumatic brain injury (TBI) is a neurotrauma with a complex pathophysiology caused by an external mechanical force. This global public health problem is a leading cause of death and disability in young adults. In this scenario, many models were developed to try to simulate human TBI. The weight drop model allows the investigation of the pathophysiological cascades of TBI without surgical interference. In this protocol, a new closed-head weight-drop rat model consisting of a 48.5g weight projectile that free falls from 1.10m high onto the skull of the animals was built. We classify the present TBI model performed as moderately severe due to its mortality rate. Animals from TBI and Control (Sham) groups underwent weight for 7 days and temperature assessments within 1 hour after TBI and for 7 days. Results demonstrated that the TBI group showed less body weight gain in the days after the injury. Temperature oscillations within the first-hour post-injury and on the 3rd day after injury were observed. As the results of this study demonstrated similarity to human TBI vital parameters, this new adaptation of the Weight-drop model injury can be a suitable candidate for translational studies.•We developed a novel closed head focal traumatic brain injury using a projectile.•This TBI model does not require surgical intervention.•The validation of this method demonstrates that the vital parameters of the injured rats exhibit similarities with those of TBI patients.

The impact of cardiovascular events in bronchiectasis: a systematic review and meta-analysis.

Bronchiectasis is a chronic respiratory condition characterised by airway and systemic inflammation with prevalence increasing with age. Given the median age of the patients, it is common to observe the presence of comorbidities, particularly cardiovascular diseases, which have been linked to adverse clinical outcomes. To investigate the pooled estimates of the association between bronchiectasis and coronary heart disease or stroke within this population, we conducted a systematic review and meta-analysis of the available scientific evidence. Three investigators independently performed the search on PubMed and other sources and included studies published up to October 2023 according to predefined criteria. Relative measures of association between bronchiectasis and cardiovascular events were pooled and meta-analysed using a fixed-effects model. Studies were evaluated using the Newcastle-Ottawa Scale for assessing the quality of non-randomised studies in meta-analyses. A final pool of nine studies was included in the systematic review, with a total of 22 239 patients. Meta-analysis of three high-quality cohort studies showed a pooled hazard ratio of 1.42 (95% CI 1.30-1.57) for coronary heart disease and 1.71 (95% CI 1.55-1.89) for cerebrovascular stroke. The increased cardiovascular risk among people with bronchiectasis underscores the critical need to raise awareness of this association and to develop preventive strategies accordingly. Further translational studies are imperative to gain a deeper understanding of the complex interplay between inflammation, the immune system and endothelial dysfunction in this patient group.

Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer’s disease rat model as a measure of early network alterations

This study investigates brain network alterations in the default mode-like network (DMLN) at early stages of disease progression in a rat model of Alzheimer’s disease (AD) with application in the development of early diagnostic biomarkers of AD in translational studies. Thirteen male TgF344-AD (TG) rats, and eleven male wild-types (WT) littermates underwent longitudinal resting-state fMRI at the age of 4 and 6 months (pre and early-plaque stages of AD). Alterations in connectivity within DMLN were characterized by calculating the nodal degree (ND), a graph theoretical measure of centrality. The ND values of the left CA2 subregion of the hippocampus was found to be significantly lower in the 4-month-old TG cohort compared to the age-matched WT littermates. Moreover, a lower ND value (hypo-connectivity) was observed in the right prelimbic cortex (prL) and basal forebrain in the 6-month-old TG cohort, compared to the same age WT cohort. Indeed, the ND pattern in the DMLN in both TG and WT cohorts showed significant differences across the two time points that represent pre-plaque and early plaque stages of disease progression. Our findings indicate that lower nodal degree (hypo-connectivity) in the left CA2 in the pre-plaque stage of AD and hypo-connectivity between the basal forebrain and the DMLN regions in the early-plaque stage demonstrated differences in comparison to healthy controls. These results suggest that a graph-theoretical measure such as the nodal degree, can characterize brain networks and improve our insights into the mechanisms underlying Alzheimer’s disease.

Basics of English-Ukrainian translation in an intercultural educational environment

The article covers the study of the basics of English-Ukrainian translation in the intercultural educational environment of Transcarpathia. The concepts of bilingual and trilingual education in institutions of higher education are defined as well as the process surrounding the formation of theoretical and practical translation skills. In the second half of the 20th century, the long-term analysis of translation activity reached such a level that it led to the creation of independent disciplines known as translation theory, translation studies, foundations of translation studies, etc. Translation studies not only developed rapidly and in a short period of time but it became an independent subject of study. The discipline also developed its own terminology which has been used for more than 50 years. The purpose of the scientific article is three-fold: 1) to study the specifics of English-Ukrainian translation; 2) to clarify the concepts of «bilingual» and «plurilingual» education; 3) to form theoretical and practical skills of English-Ukrainian translation in students while taking into account the specifics of the intercultural educational environment. The scientific novelty lies in the fact that we investigated the concept of «bilingual» and «plurilingual» education. The content and specificity of the intercultural educational environment gained further development during the English-Ukrainian translation. In the future, it is planned to study the specifics of the language components of English-Ukrainian and Ukrainian-English translations. Keywords: language, bilingual, plurilingual education, translation, intercultural educational environment.

A Multidimensional Analysis of Human and ChatGPT-Generated English Translations of Arabic Film

This study analyzed lexico-grammatical variations between two text types: human-written and machine-generated, using Biber's multidimensional analysis. It explores the effectiveness and limitations of AI-driven translation systems in maintaining the quality of film translations. It aims to add to the current discussion on the impact of AI in the field of translation. The research methodology involves selecting films from the Middle East and collecting their translations, both human-written and generated by ChatGPT. Biber's multidimensional analysis framework analyses the translations across dimensions such as involved versus informational discourse, narrative versus non-narrative concerns, explicit versus situation-dependent, overt expression of argumentation/ persuasion, and abstract versus non-abstract discourse. The findings of the analysis reveal similarities and differences between human and ChatGPT translations. Human translations are more involved, situation-dependent, argumentative, non-abstract, and less non-narrative than the translations generated by AI. However, further improvements and refinements in AI translation models could help bridge the gap between human and AI translations. The results gained from this comparative analysis offer insight into improving AI-driven translation systems, leading to more effective cross-cultural communication through film. This research will potentially contribute to the advancement of the field of translation studies by bridging the gap between human and AI translations. It provides valuable implications for the future development of AI technologies in film translation.

Strategic advancement of E3 ubiquitin ligase in the management of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) presents a significant global health challenge due to its high incidence, poor prognosis, and limited treatment options. As a pivotal regulator of protein stability, E3 ubiquitin ligase plays a crucial role in tumorigenesis and development. This review provides an overview of the latest research on the involvement of E3 ubiquitin ligase in hepatocellular carcinoma and elucidates its significance in hepatocellular carcinoma cell proliferation, invasion, and evasion from immune surveillance. Special attention is given to the functions of RING, HECT, and RBR E3 ubiquitin ligases and their association with hepatocellular carcinoma progression. By dissecting the molecular mechanisms and regulatory networks governed by E3 ubiquitin ligase, several potential therapeutic strategies are proposed: including the development of specific inhibitors targeting E3 ligases; augmentation of their tumor suppressor activity through drug or gene therapy; utilization of E3 ubiquitin ligase to modulate immune checkpoint proteins for improved efficacy of immunotherapy; combination strategies integrating traditional therapies with E3 ubiquitin ligase inhibitors; as well as biomarker development based on E3 ubiquitin ligase activity. Furthermore, this review discusses the prospect of overcoming drug resistance in hepatocellular carcinoma treatment through these novel approaches. Overall, this review establishes a theoretical foundation and offers fresh insights into harnessing the potential of E3 ubiquitin ligase for treating hepatocellular carcinoma while highlighting future research directions that pave the way for clinical translation studies and new drug discoveries.

MODL-11. LOW-GRADE GLIOMA 3D PATIENT-DERIVED ORGANOID PLATFORM AS TRANSFORMATIVE TOOL FOR TUMOR BIOLOGY AND TRANSLATIONAL RESEARCH

Abstract Unlike many high-grade tumors, low-grade glioma (LGG) has faced challenges in advancing scientific and clinical breakthroughs, affected by the limited capacity to develop representative preclinical tumor models. Major barriers to establishing traditional LGG cell culture systems have been cellular senescence and the need to introduce additional genetic modifications to obtain cultured growth. Such LGG models, while extremely valuable, require extensive periods for development and result in clonally selected lines which may not present the complexity of LGG tumor biology. To mitigate such challenges in LGG model development and address the need for three-dimensional tissue cultures, we have successfully generated organoids from fresh tissue specimens obtained from surgical resection. We have demonstrated success of this method on various pediatric brain tumor histologies and have expanded these approaches successfully to LGG. Through such efforts, we have developed 14 LGG tumors’ organoid models as well as other low-grade tumor’s models such as craniopharyngioma, schwannoma, meningioma, optic glioma, and oligodendroglioma. The tissue was processed immediately post-extraction and cultured in media solution on rotating platform. Organoid growth was observed within 1-3 weeks of initiation and tested for growth for up to 3 months. Phenotypic analysis revealed organoid cell composition representing clinical histology. The immune component was preserved in organoids for up to 40 days. MAPK pathway activity, a hallmark marker for KIAA-BRAF fusion positive pilocytic astrocytoma was preserved for up to 4 weeks. Our successful deployment of three-dimensional patient-tissue derived organoids provides for an efficient, simple workflow for the generation of unique and transformative preclinical models for the LGG field. Supported by the Children’s Brain Tumor network’s open science model, 3D organoids will provide investigations with broader resources for LGG tumor biology preclinical testing and support translational studies on behalf of the development of novel clinical trials.

Augmented Reality-Guided Extraction of Fully Impacted Lower Third Molars Based on Maxillofacial CBCT Scans

(1) Background: This study aimed to integrate an augmented reality (AR) image-guided surgery (IGS) system, based on preoperative cone beam computed tomography (CBCT) scans, into clinical practice. (2) Methods: In preclinical and clinical surgical setups, an AR-guided visualization system based on Microsoft’s HoloLens 2 was assessed for complex lower third molar (LTM) extractions. In this study, the system’s potential intraoperative feasibility and usability is described first. Preparation and operating times for each procedure were measured, as well as the system’s usability, using the System Usability Scale (SUS). (3) Results: A total of six LTMs (n = 6) were analyzed, two extracted from human cadaver head specimens (n = 2) and four from clinical patients (n = 4). The average preparation time was 166 ± 44 s, while the operation time averaged 21 ± 5.9 min. The overall mean SUS score was 79.1 ± 9.3. When analyzed separately, the usability score categorized the AR-guidance system as “good” in clinical patients and “best imaginable” in human cadaver head procedures. (4) Conclusions: This translational study analyzed the first successful and functionally stable application of the HoloLens technology for complex LTM extraction in clinical patients. Further research is needed to refine the technology’s integration into clinical practice to improve patient outcomes.

Non-human primate studies for cardiomyocyte transplantation-ready for translation?

Non-human primates (NHP) are valuable models for late translational pre-clinical studies, often seen as a last step before clinical application. The unique similarity between NHPs and humans is often the subject of ethical concerns. However, it is precisely this analogy in anatomy, physiology, and the immune system that narrows the translational gap to other animal models in the cardiovascular field. Cell and gene therapy approaches are two dominant strategies investigated in the research field of cardiac regeneration. Focusing on the cell therapy approach, several xeno- and allogeneic cell transplantation studies with a translational motivation have been realized in macaque species. This is based on the pressing need for novel therapeutic options for heart failure patients. Stem cell-based remuscularization of the injured heart can be achieved via direct injection of cardiomyocytes (CMs) or patch application. Both CM delivery approaches are in the late preclinical stage, and the first clinical trials have started. However, are we already ready for the clinical area? The present review concentrates on CM transplantation studies conducted in NHPs, discusses the main sources and discoveries, and provides a perspective about human translation.

The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues.

Spontaneously occurring glioma in pet dogs is increasingly recognized as a valuable translational model for human glioblastoma. Canine high grade glioma and human glioblastomas share many molecular similarities, including accumulation of immunosuppressive regulatory T cells (Tregs) that inhibit anti-tumor immune responses. Identifying in dog mechanisms responsible for Treg recruitment may afford targeting the cellular population driving immunosuppression, the results providing a rationale for translational clinical studies in human patients. Our group has previously identified C-C motif chemokine 2 (CCL2) as a glioma-derived T-reg chemoattractant acting on chemokine receptor 4 (CCR4) in a murine orthotopic model of glioma. Recently, we demonstrated a robust increase of CCL2 in the brain tissue of canine patients bearing high-grade glioma. We performed a series of in vitro experiments using canine Tregs and patient-derived canine glioma cell lines (GSC 1110, GSC 0514, J3T-Bg, G06A) to interrogate the CCL2-CCR4 signaling axis in the canine. We established a flow cytometry gating strategy for identification and isolation of FOXP3+ Tregs in dogs. The canine CD4 + CD25high T-cell population was highly enriched in FOXP3 and CCR4 expression, indicating they are bona fide Tregs. Canine Treg migration was enhanced by CCL2 or by glioma cell line-derived supernatant. Blockade of the CCL2-CCR4 axis significantly reduced migration of canine Tregs. CCL2 mRNA was expressed in all glioma cell lines and expression increased when exposed to Tregs but not to CD4 + helper T-cells. Our study validates CCL2-CCR4 as a bi-directional Treg-glioma immunosuppressive and tumor-promoting axis in canine high-grade glioma.

Psychometric evaluation of the Chinese version of the febrile convulsion knowledge scale for parents/caregivers: translation and validation study

BackgroundFever is one of the most common clinical symptoms of respiratory diseases in children. Once the child has a fever, parents and caregivers are mainly concerned that the child may have a febrile convulsion. A lack of cognitive ability not only leads to anxiety but also aggravates or delays the time of children’s medical treatment and even seriously affects the prognosis because of improper management of fever patients.Therefore, it is necessary to clarify the degree of mastery of knowledge related to febrile convulsions, implement targeted guidance and health education, and ensure that parents and caregivers receive correct and reasonable first aid treatment. The purpose of this study was to translate the Febrile Convulsion Knowledge Scale for Parents/Caregivers into Chinese and to verify its reliability and validity for Chinese parents and caregivers of children.MethodsThe Brislin traditional translation model was used to translate the Febrile Convulsion Knowledge Scale for Parents/Caregivers from English to Chinese, following authorization from the original author of the scale. This involved literal translation, back translation, and cultural adaptation. A convenience sampling method was used to select 402 parents and caregivers of children in the pediatric ward and pediatric infusion clinic of a Grade III hospital in Liaoning Province. The item analysis method was employed to assess item differentiation, while the Delphi method was used to analyze content validity. Scale reliability was evaluated through the calculation of internal consistency and test-retest reliability. Exploratory and confirmatory factor analyses were conducted to explore and verify the underlying factor structure and scale validity.ResultsThe Chinese version of the Febrile Convulsion Knowledge Scale for Parents/Caregivers consists of 3 dimensions and 8 items. The Cronbach’s alpha coefficient was 0.828, with each dimension having coefficients of 0.806, 0.720, and 0.702. The split-half reliability and test-retest reliability were 0.716 and 0.790, respectively. The Chinese version has good reliability. Exploratory factor analysis revealed that the Bartlett sphericity test was 394.52 (p < 0.001) and that the KMO value was 0.802 > 0.600, indicating suitability for factor analysis. Principal component analysis and orthogonal rotation of maximum variance were performed on the data, and items with a load greater than 0.40 within a single factor were selected for inclusion. The resulting three-factor structure explained 70.78% of the total variance. All model fitting indices were within the acceptable range, indicating the good structural validity of the Chinese version. The results of both exploratory and confirmatory factor analyses support this conclusion.ConclusionsThe Chinese version of the Febrile Convulsion Knowledge Scale for Parents/Caregivers has good reliability and validity. It can be used as a tool for clinical pediatric nurses to evaluate the knowledge of parents and caregivers of children with febrile convulsion and provide the basis for the design and implementation of targeted training plans according to the results obtained from the Chinese scale.

Translating Cultures Unveiling the Art of Uzbek Literary Transformations

This study conducts a linguocultural analysis of 20th-century Uzbek literary translations, illuminating the complex interaction between language and culture, particularly in the nuanced translation of stories like "Shum bola" into "A Naughty Boy." Existing research often overlooks the depth of cultural understanding required for effective literary translation, a gap this study addresses by highlighting the challenges and strategies in preserving the original texts' emotional and cultural essence. Employing an integrated approach of linguistic, cultural, and sociological methods, the research examines several translations to demonstrate how cultural context significantly impacts the translation process. Results underscore the necessity for translators to have a profound comprehension of both source and target cultures to ensure meaningful translations. The findings advocate for enhanced translator training in cultural competencies, contributing to the fields of translation studies and intercultural communication. Highlights: Intricate Relationship: Emphasizes the complex interplay between language and culture in translation. Cultural Knowledge: Highlights the essential role of deep cultural understanding for effective translation. Methodological Approach: Utilizes an integrated linguistic, cultural, and sociological framework to explore translation challenges. Keywords: Linguocultural Analysis, Translation Studies, Cultural Context, Literary Translation

Alimentary Treatment with Trehalose in a Pharmacological Model of Alzheimer's Disease in Mice: Effects of Different Dosages and Treatment Regimens.

In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several weeks. We studied the effects of different regimens of dietary trehalose treatment in an amyloid-β (Aβ) 25-35-induced murine model of Alzheimer's disease (AD). Aβ-treated mice received 2% trehalose solution daily, 4% trehalose solution daily (continuous mode) or every other day (intermittent mode), to drink for two weeks. We revealed the dose-dependent effects on autophagy activation in the frontal cortex and hippocampus, and the restoration of behavioral disturbances. A continuous intake of 4% trehalose solution caused the greatest activation of autophagy and the complete recovery of step-through latency in the passive avoidance test that corresponds to associative long-term memory and learning. This regimen also produced an anxiolytic effect in the open field. The effects of all the regimens studied were similar in Aβ load, neuroinflammatory response, and neuronal density in the frontal cortex and hippocampus. Trehalose successfully restored these parameters to the levels of the control group. Thus, high doses of trehalose had increased efficacy towards cognitive impairment in a model of early AD-like pathology. These findings could be taken into account for translational studies and the development of clinical approaches for AD therapy using trehalose.

TRANSLATION OF COLLOQUIAL EXPRESSIONS AND SLANG WORDS IN ‘THE CATCHER IN THE RYE’ FROM ENGLISH INTO AZERBAIJANI

The challenge of translating colloquial expressions and slang words is of special interest to literary translators since these elements are tied to cultural context. To explore the issue, this article analyzes J.D. Salinger’s The Catcher in the Rye and its Azerbaijani translation by Tehran Valiyev. Based on well-known theories in translation studies, the article explores what methods are used when translators come across colloquial expressions and slang words. The article addresses whether such issues are mainly due to linguistic differences or cultural ones. Additionally, the reasons for the use of the omission method in translation will be highlighted here as well. The questionnaire, along with the mixed-method approach comprising qualitative and quantitative analysis, which was distributed to 12 Azerbaijani translators, allows considerable conclusions on the strategies of different translation versions from and into colloquial language. The analysis contains 15 examples of slang words and 15 samples of original colloquial expressions from the book and its translation into Azerbaijani. The results of the study identify various methods of translation of the complete book of “The Catcher in the Rye” into Azerbaijani: adaptation, equivalent, calque, literal translate, and omission. Some translations manage to capture the essence and impact of the text while others struggle with conveying the intended message due, to differences in culture and language. The survey findings highlight the methods used by translators and underscore the importance of grasping nuances for successful translation. Respondents show a preference for adaptation seeking to connect with the target audience while preserving authenticity. Keywords: colloquial expressions, translation, slang words, cultural differences, omission.

Immune profiling of mouse lung adenocarcinoma paraffin tissues using multiplex immunofluorescence panel: a pilot study

BackgroundImmune profiling has become an important tool for identifying predictive, prognostic and response biomarkers for immune checkpoint inhibitors from tumor microenvironment (TME). We aimed to build a multiplex immunofluorescence (mIF) panel to apply to formalin-fixed and paraffin-embedded tissues in mice tumors and to explore the programmed cell death protein 1/ programmed cell death 1 ligand 1 (PD-1/PD-L1) axis.ResultsAn automated eight-color mIF panel was evaluated to study the TME using seven antibodies, including cytokeratin 19, CD3e, CD8a, CD4, PD-1, PD-L1, F4-80 and DAPI, then was applied in six mice lung adenocarcinoma samples. Cell phenotypes were quantified by software to explore the co-localization and spatial distribution between immune cells within the TME. This mice panel was successfully optimized and applied to a small cohort of mice lung adenocarcinoma cases. Image analysis showed a sparse degree of immune cell expression pattern in this cohort. From the spatial analysis we found that T cells and macrophages expressing PD-L1 were close to the malignant cells and other immune cells.ConclusionsComprehensive immune profiling using mIF in translational studies improves our ability to correlate the PD-1/PD-L1 axis and spatial distribution of lymphocytes and macrophages in mouse lung cancer cells to provide new cues for immunotherapy, that can be translated to human tumors for cancer intervention.