This study proposes a sandwiched composite locally resonant metamaterial (SLRM) system and SLRM-embedded plate structure (SLRMeP) to effectively control low-frequency vibrations and sound radiation. The wave control mechanism and configuration of the proposed system are more suitable and realistic to address practical low-frequency vibro-acoustic problems. A numerical model was proposed based on the material properties, unit dimensions, and mass ratios to determine the local resonance characteristics and bandgap formation. The experimental results on a full-scale SLRMeP measuring 3000 × 4200 × 210 mm confirmed the efficacy of the local resonance bandgap for controlling vibrations and sound radiation, achieving a 94.08% reduction in the acceleration response and a 15.13 dB reduction in the sound pressure level. Additionally, variations in mass ratio, achieved by altering the mass density or dimensions, yield distinct bandgap behaviors, offering strategies to enhance vibro-acoustic performance.