With an enlarging community using electronic design automation, it is a prominent challenge to provide simulation program with integrated circuit emphasis (SPICE) users with sophisticated integrated circuit (IC) models, since many analog IC manufacturers provide software models in SPICE format. Multi-core technology-based processors deliver better performance-to-cost ratios relative to their single-core predecessors through on-chip multithreading. In this article, we present a parallel version of a SPICE3 circuit simulator using two well-known shared-memory multithread programming interfaces. Two approaches in multithread programming has been considered and proposed to parallelize SPICE3 programs in shared-memory multiprocessor systems. Also, OpenMP and Pthreads libraries are considered to realize the proposed approaches that are used to redesign the SPICE3 device-loading functions. Case studies using SRAM circuits as input data were investigated. They consist of MOS devices modeled using BSIM3 models. Performance results from multi-core multiprocessor-based servers exhibit performance improvement of multithreaded implementation over the original version of SPICE3 circuit simulator.