Soothing Effect Research Articles

The Effects of Different Strategies on the Painful Procedure Management, and the Physiological Parameters in Preterm Infants: A Systematic Review

Background: Since preterm infants are subjected to numerous painful and stressful procedures, various strategies reducing the effects during and after painful procedures are required; we aimed to review the effectiveness of the use of different strategies as a primary or adjunctive treatment on the painful procedures, and the physiological parameters in preterm infants. Materials and Methods: In this systematic review, English databases such as PubMed, Scopus, ISI Web of Science, Cochrane Library and EMBASE were systematically searched without any time limitation up to February 2019. The search keywords were (Aromatherapy OR Olfactory OR Amniotic Fluid OR Milk or odor) AND (Pain OR Venipuncture). Results: Finally, four articles were included. The first study conducted on four groups indicates that the pain profile score and the crying time slightly differed during and after the heel prick procedure. In the second study, having pricked the heel, the breast milk group in comparison with the formula milk group embodied the lower premature infant pain profile (PIPP) score. According to the third study, both the vanilla and the breast milk odors groups indicated soothing effects on the premature infants during sampling; and only the breast milk odor is the soothing factor affecting the infants after the sampling termination. The fourth study found that the infants, who were exposed to their own mother’s milk odor, when compared with the control group, encompassed the lowest median PIPP score during venipuncture. Conclusion: Amniotic fluid, the mother’s milk, vanilla and the mother’s odor were determined as reduction and enhancement factors affecting painful procedures and physiological parameters in preterm infants, respectively.

Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances.

Wound dressings are traditionally used to protect a wound and to facilitate healing. Currently, their function is expanding. There is an urgent need for new smart products that not only act as a protective barrier but also actively support the wound healing process. Hydrogel dressings are an example of such innovative products and typically facilitate wound healing by providing a hospitable and moist environment in which cells can thrive, while the wound can still breathe and exudate can be drained. These dressings also tend to be less painful or have a soothing effect and allow for additional drug delivery. In this review, various strategic and molecular design considerations are discussed that are relevant for developing a hydrogel into a wound dressing product. These considerations vary from material choice to ease of use and determine the dressing's final properties, application potential, and benefits for the patient. The focus of this review lies on identifying and explaining key aspects of hydrogel wound dressings and their relevance in the different phases of wound repair. Molecular targets of wound healing are discussed that are relevant when tailoring hydrogels toward specific wound healing scenarios. In addition, the potential of hydrogels is reviewed as medicine advances from a repair-based wound healing approach toward a regenerative-based one. Hydrogels can play a key role in the transition toward personal wound care and facilitating regenerative medicine strategies by acting as a scaffold for (stem) cells and carrier/source of bioactive molecules and/or drugs. Impact statement Improved wound healing will lead to a better quality of life around the globe. It can be expected that this coincides with a reduction in health care spending, as the duration of treatment decreases. To achieve this, new and modern wound care products are desired that both facilitate healing and improve comfort and outcome for the patient. It is proposed that hydrogel wound dressings can play a pivotal role in improving wound care, and to that end, this review aims to summarize the various design considerations that can be made to optimize hydrogels for the purpose of a wound dressing.

The Potential Application of Ecklonia cava Extract in Scalp Protection

The scalp is exposed to environmental hazards including airborne pollutants, which exert adverse effects on skin health. Therefore, compounds for defending skin from pollutants have attracted interest in the cosmeceutical community. We investigated whether Ecklonia cava exhibited prophylactic effects against urban pollutants by measuring cell viability and cell cycle distribution in human follicle dermal papilla cells (HFDPC). The effect of E. cava on pollutant-induced damage to skin barrier was determined by measuring filaggrin and MMP-1 expression in both keratinocytes and in a skin explant model. In a clinical trial, the effect of E. cava on scalp skin of patients with scalp scale was observed by evaluating hydration and redness after 4 weeks of daily treatment with a shampoo containing E. cava extract. E. cava extract recovered the loss of cell viability and abnormal cell cycle distribution induced by urban pollutants in HFDPCs. It also attenuated pollutant-induced damage to skin barrier by decreasing MMP-1 and increasing filaggrin expression in keratinocytes and the epidermis of skin explants. Moreover, E. cava showed soothing effects on human scalp by increasing hydration and decreasing redness in a clinical trial. Collectively, E. cava extract may be a good candidate for therapeutic applications designed to repair or protect hair scalp.

Pediatric sialendoscopy: An 11-year study from a single tertiary care center

ObjectivesTo evaluate the suitability, benefits, and limitations of sialendoscopy for pediatric patients. MethodsWe performed a retrospective analysis of all pediatric sialendoscopy patients (aged 16 years or younger) in our tertiary care institution between September 2007 and October 2018. We characterized patient data, procedure-related factors, complications, and outcomes. ResultsIn total, 55 sialendoscopies were performed on 42 patients. Among these, 36 were diagnostic endoscopies and 19 were interventional. Five endoscopies were performed under local anesthesia. We identified 16 sialolithiasis patients, where removal of a sialolith was possible in 11 (69%) cases; one case required a second endoscopy. We removed two sialoliths under local anesthesia. Among recurrent juvenile parotitis (RJP) patients, 18/20 (90%) were symptom-free after a single sialendoscopy, and all after a second endoscopy. The median follow-up time was 70 months. We achieved a 95% success rate in sialendoscopies, with a failure-to-treat rate of 15%. The complication rate for the study cohort was 2%, with prolonged parotid swelling the only complication encountered. ConclusionsSialendoscopy represented a safe and effective method to treat pediatric patients. Local anesthesia was successful in selected cases, even for sialolith removal. Sialendoscopy had a soothing effect on RJP and the majority of sialoliths were suitable for endoscopic removal.

Acute Wound Healing Potential of Marine Worm, Diopatra claparedii Grube, 1878 Aqueous Extract on Sprague Dawley Rats.

Diopatra claparedii which is colloquially known as Ruat Sarung can be found along the west coast of Peninsular Malaysia. The species has a unique ability to regenerate anterior and posterior segments upon self-amputation or injury, thus having potential as a wound healing promoter. In this study, the wound healing potential of D. claparedii aqueous extract on acute wound model in rats was revealed for the first time. Various concentrations (0.1%, 0.5%, and 1.0% w/w) of D. claparedii ointment were formulated and tested on Sprague Dawley rats through topical application on full-thickness skin wounds for 14 days. The wound healing effects were investigated via behaviour observation, wound contraction, and histopathological analysis. Quality assessment was performed via skin irritation test, microbial contamination test (MCT), and heavy metal detection. The study also included test for antibacterial activities and detection of bioactive compounds in D. claparedii. One percent of D. claparedii ointment showed rapid wound healing potential with good soothing effects and more collagen deposition in comparison to the commercial wound healing ointments such as acriflavine (0.1% w/v) and traditional ointment gamat (sea cucumber extract) (15.0% w/v). No local skin irritation, microbial contamination, and insignificant concentration of heavy metals were observed, which indicate its safe application. Moreover, the aqueous extract of D. claparedii exhibited antibacterial activities against Escherichia coli and Pseudomonas aeruginosa with minimum inhibitory concentration (MIC) value at 0.4 g/ml. 1H NMR analysis of the aqueous extract of D. claparedii revealed some metabolites that might be responsible for its wound healing properties such as amino acids, halogenated aromatics, organic acids, vitamins, and others. Altogether, these results suggested that the aqueous extract of D. claparedii could be utilised as an alternative natural wound healing promoter.

Soothing effect of virgin coriander seed oil on sensitive skin

Sensitive skin is a common condition that concerns many people in the world. This syndrome is defined by the occurrence of unpleasant sensations such as stinging and burning in response to stimuli that normally should not provoke such sensations. The main hypothesis attributed to the occurrence of sensitive skin is the disruption of the epidermal barrier and a greater penetration of substances such as irritants. In keratinocytes, the NF-κB pathway, which plays an important role in orchestrating inflammatory responses, is then activated. Regulation of this activation is a key issue to control inflammation. Due to the wide variety of sensory symptoms, neurosensory dysfunction also represents a mechanism to be considered. Some of the cutaneous nerve endings express TRPA1, a sensor of skin barrier insult, which is involved in a variety of physiological or cellular processes including nociception, itch and neurogenic inflammation. Regulation of such sensor activation is also an issue to consider to control neurosensory dysfunction. Coriander seed oil is a 100% virgin oil of coriander seeds and boasts a unique composition of fatty acids. The soothing effect of coriander seed oil on sensitive skins was investigated by studying its capacity to regulate NF-κB and TRPA1 activation. Coriander seed oil allowed the regulation of NF-κB activation induced by TNF-α in an in vitro model of inflammation in keratinocytes. It also regulated the activation of TRPA1 induced by allyl isothiocyanate in an in vitro model of keratinocytes-neurons co-culture. These results are in favor of a soothing effect of coriander seed oil.

Study of the Cutaneous Tolerability and Safety of V-Bath-an Intimate Hygiene Daily-use Product

Background/Objective: Several products containing various combinations of lactic acid, aloe vera, milk protein or lactoserum are commercially available, however evidence of its effectiveness in maintaining physiological pH and other subjective parameters in Indian women is lacking. Hence, to confirm the compatibility and tolerability of the intimate hygiene product V-Bath which is a combination of lactic acid, aloe vera, and milk protein when used daily, the current study was undertaken. Method: This was a prospective, open-label, cross-over and singlecenter study in healthy female volunteers conducted under the supervision of dermatologists. The test product was V-Bath Intimate Wash and the control products were two bathing soaps to be used by an equal number of females for 7 days prior to or after crossover depending on their usage of products before participation in the study. At baseline or day 0, week 1 and week 2, each subject underwent clinical assessment for cutaneous tolerability and safety; at the same time points, subjects’ assessment was obtained using a sensory questionnaire with scores for each parameter. pH assessments were done at the same time points (Day 0, week 1 and week 2) by measuring pH before and after usage of the V-Bath and soap at the centre. Statistical analysis used: A paired ‘T’ test with a 2-sided significance level of 5%. Results: None of the thirty-three subjects reported erythema, itching, boils, foul smell, burning sensation, swelling, watery discharge or white/yellow discharge during the study period in response to the intervention of V-Bath or comparator soaps. There was no significant skin intolerance experienced by any of the subjects after the use of V-Bath for 7 days. According to the analyses of the subject self-assessment records, a significant proportion of the population agreed that the product (VBath) was able to prevent odor, irritation and itchiness and provided moisturization and a soothing effect on the skin with single-use as well as regular 1-week use. The decrease in pH of the intimate area remaining from baseline (pre-wash) to the post-1-week use was significant (p=0.0230) with V-Bath unlike soap which was not found to be significant.

Characterization of Reactive and Sensitive Skin Microbiota: Effect of Halymenia durvillei (HD) Extract Treatment

After characterization of the reactive skin microbiota, we investigated whether the active Halymenia durvillei (HD), rich in polysaccharides, could modulate this microbiota after 28 days of treatment, act on neuroinflammation parameters, and calm feelings of discomfort and redness. Skin microbiota was assessed using next-generation sequencing experiments (16S RNA gene fragment sequencing) on samples collected from 30 volunteers suffering from reactive, sensitive skin. To evaluate the effect of the HD extract on neuroinflammation, we used an ex vivo model. Finally, an in vivo study was performed using a clinical assessment (blood microcirculation via videocapillaroscopy) of functional signs employing the Sensitive Scale and the soothing effect was evaluated and compared to a placebo treatment. At the phylum level, the samples were mostly composed of Actinobacteria, Proteobacteria, Firmicutes, and Bacteroidetes, which accounted for more than 97% of the total sequencing read in all samples, with no differences before or after treatment with the HD active ingredient. The Shannon Diversity index indicated lower microbial communities compared to healthy skin. Maintenance of the Shannon Diversity index was reported after 28 days of HD active ingredient treatment, wherein microbial communities continued to decrease in number during treatment with the placebo. The average taxonomic composition of associated skin microbial communities showed that reactive skin is characterized by a low proportion of the Chryseobacterium genus compared to a high proportion of the Corynebacterium genus. At the species level, Actinobacteria are mainly represented by Propionibacterium acnes (72.13%) and Corynebacterium kroppenstedtii (13.23%), representing species typically observed in clinical cases of redness, the main criteria for volunteer inclusion. Corynebacterium kroppenstedtii, with increased levels being associated with skin redness, decreased with HD treatment. This decrease coincided with the clinical improvement observed after 7 weeks of treatment. The ex vivo study revealed that the HD extract induced a significant decrease in the expression of TRPV-1 (−67%; p < 0.001) and NK1-R (−43%; p < 0.01) compared to the control after 6 days of treatment. These data support the use of polysaccharides, found in red alga, in the treatment of reactive and sensitive skin related to the modulation of skin microbiota.

PHARMACOLOGICAL NEUROPROTECTIVE EFFICACY OF ESSENTIAL OILS (EO) BASED AROMATHERAPY: AN INSIGHT

Aromatherapy or Essential oil therapy is attributed towards the field of conventional, alternative or complementary therapies which requires essential oils and other aromatic plant compounds. Essential oils (EOs) belong to the class of highly volatile compounds which, due to their higher concentrated natural constituents acquire unique properties and hence, are being used for its wide range of therapeutic health benefits. Their benefits widely range from being a potential antimicrobial, antidepressant, antiviral and antiseptic agents to the elevator of many CNS related behaviours like - anxiety, stress, wisdom, memory, attention, relaxation, sedation, and sleep. Furthermore, the effects on mood, pain, and perception too are being influenced by the use of essential oils. It also helps in the treatment of epilepsy, stress, dementia by giving calming and soothing effects to the nerve cells and is also effective against dementia and on the treatment of Alzheimer’s disease.

Bedside Music Therapy for Women during Antepartum and Postpartum Hospitalization.

Stress and anxiety are prevalent during pregnancy and postpartum with adverse effects on mothers and newborns, yet women's psychological and emotional needs are often given a lower priority than their physical wellbeing. The purpose of this study was to assess feasibility of implementing a bedside music therapy intervention to alleviate stress and anxiety, provide emotional support, and facilitate mother-baby bonding for women during antepartum and postpartum hospitalization at a large urban medical center. Over 15 months, women on three units who were hospitalized during antepartum or postpartum were referred for music therapy and received a single bedside session from a credentialed music therapist (MT-BC), including tailored interventions and education in relaxation techniques. A retrospective analysis of postintervention feedback questionnaires and process notes was conducted to assess participant receptivity and satisfaction, and the feasibility of implementing the program on the units. Music therapy was provided to 223 postpartum and 97 antepartum patients. The program was found to be feasible and well received, including high satisfaction, positive effects on participants' relaxation and sense of connection with their baby, and enthusiastic reception from providers and staff. Qualitative feedback revealed salient themes including the effect of the intervention on mothers' mental, emotional and physical states, and the soothing effect of music on their newborns. Hospitals are in a unique position to provide support services and self-care education for women during their antepartum and postpartum hospitalization. Music therapy can be integrated successfully into inpatient care as a nurturing and patient-centered form of psychosocial support.

Economic fluctuations and cardiovascular diseases: A multiple-input time series analysis.

ObjectivesLittle is known about the gender and age differences associated with the effects of economic fluctuations on hospitalization for cardiovascular diseases. This paper investigates the impact of economic fluctuations on hospitalization for ischemic heart disease (IHD), stroke, and hypertension by age and gender between January 1996 and December 2012 in Taiwan.MethodsWe adopted a multiple-input time series analysis to examine the strength of the immediate and latent effects of the 17-year quarterly unemployment rates (UR), air pollution exposure (APE), gross domestic product (GDP), per capita consumption expenditure in cigarette and alcohol (ECA), and per capita healthcare expenditure (HE) on the adjusted quarterly incidence rate of hospitalization. The data used in this paper were retrieved from the National Health Insurance Research Database and the website of the Directorate-General of Budget, Accounting and Statistics (DGBAS), Executive Yuan.ResultsOur findings indicate that higher UR increased IHD hospitalization in young men and women and middle-aged women but reduced stroke hospitalization in young men. Higher APE increased IHD hospitalization in young men but reduced it for young women, increased stroke hospitalization in old men and middle-aged women but reduced it for young men, and increased hypertension hospitalization in middle-aged men and young women. Higher ECA reduced IHD hospitalization in middle-aged men, increased stoke hospitalization in middle-aged and old men and middle-aged women. Higher HE reduced IHD hospitalization in old men, young and old women, reduced stroke hospitalization in old women, and reduced hypertension hospitalization in young and middle-aged women.ConclusionsOverall, we found that the economic fluctuations caused increased harmful effects in certain population subgroups but also brought some soothing effects to some groups.

Surface modified natural zeolites (SMNZs) as nanocomposite versatile materials for health and environment

The present research deals with the evaluation of a clinoptilolite-rich rock, occurring in the Nižný Hrabovec deposit (Slovakia), for high-value technological applications based on sorption and in vitro release of nonsteroidal anti-inflammatory drugs (i.e., ibuprofen sodium salt). This georesource was surface modified (SMNZ) using four cationic surfactants. Results demonstrate that ibuprofen sorption is very fast and SMZNs can sorb up to ˜26 mg/g of drug as a function of the type of counterion and morphology of surfactant, as well as the hydrophobicity and molecular structure of the drug. Maximum sorption capacities observed for all SMNZs are fully comparable to other adsorbent carriers usually used for removal of contaminants in wastewaters. Sorption of ibuprofen is controlled by a dual mechanism: external anionic exchange and partition into the hydrophobic portion of the patchy bilayer. A prompt drug release in simulated intestinal fluid (SIF) was also observed, making this natural material also suitable to provide rapid soothing effects in potential pharmacological applications.Comparing the results of this study with other recent investigations, a good technological performance of clinoptilolite-rich rock can be inferred despite the relatively low zeolite content (˜56 wt.%).

Comparing the course of anxiety in women receiving their first or repeated caesarean section: A prospective cohort study

BackgroundAround 30% of births are through caesarean section and repetition rates for receiving a caesarean section are high. AimThe aim of the prospective study was to compare the course of anxiety in women undergoing their first caesarean section and women experiencing a repeated caesarean section. Participants304 women with an indication for an elective caesarean section took part. 155 received their first caesarean section and 149 received a repeated caesarean section. MethodsIn order to measure the course of anxiety on the day of the caesarean section subjective anxiety levels were measured and saliva samples for cortisol determination were taken at admission, during skin closure and two hours after the surgery. Blood pressure and heart rate were documented at skin incision and skin closure. ResultsWomen experiencing their first caesarean section displayed significantly higher anxiety levels compared to women with a repeated caesarean section. Scores of the STAI-State and visual analogue scale for anxiety differed significantly at admission (p=.006 and p<.001) and heart rate and alpha amylase levels were significantly higher at skin closure (p=.027 and p=.029). ConclusionThe results show that previous experience with a caesarean section has a soothing effect. The study aims to sensitize surgeons, anesthetists, nurses and midwives when treating women receiving a caesarean section and encourage them to incorporate soothing interventions, especially for women receiving their first caesarean section to reduce anxiety levels and consequently improve postoperative recovery and patients’ satisfaction.

Postoperative treatment after partial nail ablation of ingrown toenails — does it matter what we recommend? A blinded randomised study

Trial design: In this blinded randomized study we analyzed patient reported outcome of three different treatments after nail surgery. We compared daily footbath with either alkaline or acidic soap or just a simple bandage of gauze dressing.Method: After partial nail ablation surgery, patients were randomized into three postoperative treatment modalities. Outcome in terms of reduction in pain, improvement of function, reduction of signs of infection and postoperative soothing effect were reported after one and two weeks. A generalized linear mixed model was used to analyze possible statistical differences between the groups.Results: 97 patients, 57% women, mean age 31 years, were included. Men reported significantly less pain and better function than women. Despite a registered lower growth of invasive pathogenic microbes following the use of acidic soaps, this did not lead to less infections than in the groups using either alkaline soap baths or bandaging. On the contrary, patients keeping the bandage on had significantly lower signs of infection after one week. Two patients using soap baths had growth of MRSA. Two weeks postoperatively, all three treatment alternatives had similar patient reported outcome in all parameters, and nobody needed antibiotics.Conclusions: This prospective randomized study was unable to prove that footbath with either acidic or alkaline soap should be preferred to just leave the postoperative bandage on for a week after partial nail ablation. We recommend that postoperative advice should be given on an individual basis, especially since our study did not involve patients with high risk of infections.

Effect of massage on behavioural responses of preterm infants in an educational hospital in Iran

ABSTRACTObjective: The aim of this study was to assess the effect of providing massage (tactile and kinesthetic stimulation) on behavioural responses for preterm infants.Background: These infants have immature central nervous systems. Sleep–wake states during infancy have been shown to reflect severity of disease developments, and the nervous system and brain maturation.Methods: This study is a quasi-experimental study with before and after design conducted on 45 preterm infants who were admitted in neonatal intensive care unit (NICU). The subjects received massage 15 min per day for 5 days using field massage technique. Behavioural responses were measured by behavioural state, motor activity and behavioural distress. Data were obtained 10 min before and 10 min after the providing massage period.Results: An increase was observed in sleep state score after providing massage. And also, the awake, fidgeting and motor activity scores reduced after providing massage. No significant change was seen in the total behavioural distress.Conclusion: The findings suggest that providing field massage had soothing and calming effect on preterm infants and could be beneficial in nursing intervention. Nurses working in neonatal intensive care unit need to be educated on how to performing the massage on preterm infants.Abbreviation: NICU: Neonatal Intensive Care Unit

Natural Antibacterial Clays: Historical Uses and Modern Advances

AbstractAntibacterial clays in nature include a variety of clay mineral assemblages that are capable of killing certain human pathogens. Although clays have been used for medicinal applications historically, only in the last decade have analytical methods and instrumentation been developed that allow researchers to evaluate the antibacterial mechanisms of various clays applied medicinally. Comparisons of the mineralogical and chemical compositions of natural clays that kill bacteria have promoted a better understanding of the mineral properties that are toxic to a broad-spectrum of human pathogens, including bacteria that have developed resistance to antibiotics. Popular literature is filled with reports of ‘healing’ clays, that, when tested against pathogens in vitro and compared to controls, do not appear to have bactericidal properties. It is important, however, to differentiate what properties make a clay ‘healing,’ versus what makes a clay ‘antibacterial.’ Most antibacterial clays identified to date buffer pH conditions of a hydrated clay outside the range of conditions in which human pathogens thrive (circum-neutral pH) and require oxidation reactions to occur. It is the change in oxidation state and pH imposed by the hydrated clay, applied topically, that leads to a chemical attack of the bacteria. Healing clays, on the other hand, may not kill bacteria but have soothing effects that are palliative. This article reviews some of the historical uses of clays in medicine but focuses primarily on the common characteristics of natural antibacterial clays and early studies of their antibacterial mechanisms. In this era of bacterial resistance to antibiotics, mimicking the antibacterial mechanisms exhibited by natural clays could be advantageous in the development of new antimicrobial agents.

The effects of negative context and attachment security priming on working memory updating among anxiously attached individuals

Two studies using event-related potentials ERPs) combined with emotional versions of 2-back tasks were performed to examine the effects of negative context on working memory (WM) updating task performance among anxiously attached individuals. One study also assessed the soothing effect of priming memories of attachment security on task performance. Three types of information, including negative attachment pictures, general negative pictures and neutral pictures, were used as materials in the present study. Impairment in WM updating capacity was found in the context of negative attachment pictures in both studies, and the ERP results revealed the following dynamic process: the participants showed enhanced attention to negative attachment stimuli during the initial encoding stage, as expressed by a larger P1, but undue immersion in negative emotion led to a reduced P300 during the elaborate stage. However, security priming was useful in reducing mood disturbance in the context of a WM updating task, and the participants performed better on the task after secure attachment activation. The implications of these findings for emotional WM updating capacity and information processing patterns among anxiously attached individuals are discussed.

High-approach and low-approach positive affect influence physiological responses to threat and anger

Positive affect has been related to faster cardiovascular recovery from stress. Although the family of positive affective states is diverse, no study examined whether high-approach positive affect (e.g., desire) has a different impact on peripheral physiological processes than more frequently studied low-approach positive affect (e.g., amusement). Building upon prior work on emotions and motivation, we expected that after controlling for arousal and valence, positive affect with higher motivational intensity would facilitate weaker recovery when compared to positive affect with lower motivational intensity. Across two experiments (N = 179 for Study 1, N = 220 for Study 2), we measured cardiovascular, respiratory, and electrodermal responses to positive stimuli that differed in approach intensity. We measured responses during recovery from stress and during reactivity to threat and anger. These studies partially replicated previous findings regarding the soothing function of positive affect (e.g., in respect to diastolic blood pressure recovery and reactivity). However, we found that high-approach and low-approach positive affect produced comparable effects. In summary, these findings suggest that positive valence rather than motivational intensity produces the main soothing effect on peripheral physiology.

Evaluation of the soothing effect of Eupilen® topical formulation on radiotherapy-induced dermatitis

Evaluation of the soothing effect of Eupilen® topical formulation on radiotherapy-induced dermatitis

Evaluation of efficacy of oral honey use in adult tonsillectomy patients

Post-tonsillectomy throat pain is one of the most common complication, which leading to delayed recovery and later hospital discharge. This study aims to evaluate the effectiveness of oral honey use on eating, condition and reducing pain with patients have applied tonsillectomy. The study included 72 patients (37 males, 35 females; mean age 26±4.16 years; range 18 to 36 years) who were applied tonsillectomy. Patients were randomized into two groups. The treatment group received postoperatively followed by oral consumption of honey three times daily for five days PatientsÂ’ pain, eating and condition situation was assessed with visual analog scale(VAS), and analgesic intake was recorded during five follow-up periods. There was no statistically different between two groups about postoperative pain at first three days. But the postoperative pain was statically significant less at honey group than the control group. There was also a significant decrease in the number of analgesics taken over the last three control periods in terms of the honey group. The eating situation was statically significant better in the honey group than the control group at all days. The patientsÂ’ condition was also better in the honey group at all days. The result of study, the early postoperative pain was relieved slightly faster in the honey + antibiotic group, which may be attributed to the soothing effect of honey. This situation improves the oral intake of the patients and shortens the recovery process in the postoperative period.