Soothing effect of virgin coriander seed oil on sensitive skin

Christian Gombert,Alicia Roso,Catherine Kern,Christine Garcia

doi:10.1051/ocl/2020043

Abstract

Sensitive skin is a common condition that concerns many people in the world. This syndrome is defined by the occurrence of unpleasant sensations such as stinging and burning in response to stimuli that normally should not provoke such sensations. The main hypothesis attributed to the occurrence of sensitive skin is the disruption of the epidermal barrier and a greater penetration of substances such as irritants. In keratinocytes, the NF-κB pathway, which plays an important role in orchestrating inflammatory responses, is then activated. Regulation of this activation is a key issue to control inflammation. Due to the wide variety of sensory symptoms, neurosensory dysfunction also represents a mechanism to be considered. Some of the cutaneous nerve endings express TRPA1, a sensor of skin barrier insult, which is involved in a variety of physiological or cellular processes including nociception, itch and neurogenic inflammation. Regulation of such sensor activation is also an issue to consider to control neurosensory dysfunction. Coriander seed oil is a 100% virgin oil of coriander seeds and boasts a unique composition of fatty acids. The soothing effect of coriander seed oil on sensitive skins was investigated by studying its capacity to regulate NF-κB and TRPA1 activation. Coriander seed oil allowed the regulation of NF-κB activation induced by TNF-α in an in vitro model of inflammation in keratinocytes. It also regulated the activation of TRPA1 induced by allyl isothiocyanate in an in vitro model of keratinocytes-neurons co-culture. These results are in favor of a soothing effect of coriander seed oil.

Highlights

Introduction on sensitive skin1.1 Definition and overviewSensitive or reactive skin is a common condition that concerns approximately 50 % of people. 60 % women and 40 % men report having reactive skin, and the prevalence can vary depending on the country (Misery et al, 2017)
These data show that coriander seed oil (CSO) was able to regulate NF-kB activation in inflammatory conditions in keratinocytes, and can contribute to regulate inflammation by this way (Fig. 4)
AITC 1 mM induced a huge and significant increase in TRPA1 activation (þ585% vs. untreated cells, p < 0.001) in keratinocytes-neurons co-culture

Summary

Introduction

Introduction on sensitive skin1.1 Definition and overviewSensitive or reactive skin is a common condition that concerns approximately 50 % of people. 60 % women and 40 % men report having reactive skin, and the prevalence can vary depending on the country (Misery et al, 2017). A consensus definition was proposed by a working group (special interest group on sensitive skin of the International Forum for the Study of Itch) as: “A syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that normally should not provoke such sensations. These unpleasant sensations cannot be explained by lesions attributable to any skin disease. Described sensations can vary largely: pain, pruritus, burning, tingling, prickling, pungency, thickening or dryness of the skin, and may or may not be accompanied by signs such as redness, mild erythema, telangiectasias, xerosis, desquamation, or urticaria

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