Throughout the ages and with the changes of nature, humanity stands now at a turning point in its relationship with the planet and its ecosystems. Architecture has been derived from nature as a source of inspiration and formation. The idea that is a science that observes and studies nature as a concept that changes the awareness of simulation. Through the trend in design, integration with nature and climatic changes conditions, using technologies that are compatible with the surrounding environment. The problem is the gap between the industrial and the simulated systems' intellectual approach. The interior design and became not adapted to their environment, but rather separate from the systems. The goal is to create an interior with an system characterized by integration with the natural environment through the concept of biological simulation and adaptive architecture to reach sustainable designs. That is by linking the scientific method and the descriptive approach through an analytical view of the concept of and design development. Finally, the research can reach the transformation of the intellectual approach into the of the natural approach in interior design with attention to the cultural role and guidance towards protecting and respecting the environmental systems.