We present 2D full quantum simulation based on the self-consistent solution of 2D Poisson–Schrödinger equations, within the nonequilibrium Green’s function formalism, for a novel multiple region silicon-on-insulator (SOI) MOSFET device architecture – tri-material double gate (TMDG) SOI MOSFET. This new structure has three materials with different work functions in the front gate, which show reduced short-channel effects such as the drain-induced barrier lowering and subthreshold swing, because of a step function of the potential in the channel region that ensures the screening of the drain potential variation by the gate near the drain. Also, the quantum simulations show the new structure significantly decreases leakage current and drain conductance and increases on–off current ratio and voltage gain as compared to conventional and dual material DG SOI MOSFET.