Now-a-days non-traditional methods and tools are introduced in the training of medical students which are mediated by the rapid development of information technologies: software training systems, Serious Games, and video materials. The paper presents a software system for the processing and analysis of physiological data, which is suitable for use in the medical students’ training process and a study has been made of the use of serious games in medical education. For optimal work with a software system, a database of cardiac data has been created for healthy individuals and individuals with various cardiac diseases. The established system and the cardiology database can be used by medical doctors to study statistical parameters and graphical cardiac data representation in various diseases. The results obtained from the analysis of the data through graphical methods can be used as an effective visual means for increasing the success of medical students' training. The paper presents the results of a survey of the interest of medical students in higher education Universities in Bulgaria to the inclusion of Serious Games in their medical training. The results show a high interest in game-based learning: by including serious games such as innovative training, it will be possible to build on theoretical education and to increase the efficiency of the education process.