Abstract. Evapotranspiration (ET) is responsible for regulating the hydrological cycle, with a relevant impact on air humidity and precipitation that is particularly important in the context of acute drought events in recent years. With the intensification of rainfall deficits and extreme heat events, the Mediterranean region requires regular monitoring to enhance water resource management. Even though remote sensing provides spatially continuous information for estimating ET on large scales, existing global products with spatial resolutions ≥ 0.5 km are insufficient for capturing spatial detail at a local level. In the framework of ESA's 4DMED-Hydrology project, we generate an ET dataset at both high spatial and high temporal resolutions using the Priestley–Taylor Two-Source Energy Balance (TSEB-PT) model driven by Copernicus satellite data. We build an automatic workflow to generate a 100 m ET product by combining data from Sentinel-2 (S2) MultiSpectral Instrument (MSI) and Sentinel-3 (S3) land surface temperature (LST) with ERA5 climate reanalysis derived within the period 2017–2021 over four Mediterranean basins in Italy, Spain, France, and Tunisia (Po, Ebro, Hérault, and Medjerda). First, original S2 data are pre-processed before deriving 100 m inputs for the ET estimation. Next, biophysical variables, like leaf area index and fractional vegetation cover, are generated, and then they are temporally composited within a 10 d window according to S3 acquisitions. Consequently, decadal S2 mosaics are used to derive the remaining TSEB-PT inputs. In parallel, we sharpen 1 km S3 by exploiting the dependency between coarse-resolution LST and 100 m S2 reflectances using a decision tree algorithm. Afterwards, climate forcings are utilized to model energy fluxes and then for daily ET retrieval. The daily ET composites demonstrate reasonable TSEB-PT estimates. Based on the validation results against eight eddy covariance (EC) towers between 2017 and 2021, the model predicts 100 m ET with an average RMSE of 1.38 mm d−1 and a Pearson coefficient equal to 0.60. Regardless of some constraints mostly related to the high complexity of EC sites, TSEB-PT can effectively estimate 100 m ET, which opens up new opportunities for monitoring the hydrological cycle on a regional scale. The full dataset is freely available at https://doi.org/10.48784/b90a02d6-5d13-4acd-b11c-99a0d381ca9a, https://doi.org/10.48784/fb631817-189f-4b57-af6a-38cef217bad3, https://doi.org/10.48784/70cd192c-0d46-4811-ad1d-51a09734a2e9, and https://doi.org/10.48784/7abdbd94-ddfe-48df-ab09-341ad2f52e47 for the Ebro, Hérault, Medjerda, and Po catchments, respectively (Bartkowiak et al., 2023a–d).