Search For New Mechanisms Research Articles

Clinical management of treatment-resistant depression

Treatment-resistant depression (TRD) is acomplex disorder. Although no standardized definition has been established to date, there are promising and well-established treatment options for the condition. Looking at the current pharmacological and neuromodulatory strategies, there is an urgent need for fast-acting and well-tolerated treatment options. The search for new mechanisms of action goes beyond the monoamine hypothesis. For example, esketamine is already an established treatment method that is fast-acting and well tolerated, while psychedelics or esmethadone are currently still undergoing clinical trials. Compounds that can be used off-label, such as dextromethorphan or anti-inflammatory strategies are also presented. Pharmacological approaches that focus on the modulation of the glutamatergic system or belong to the class of psychedelics, appear to be of particular importance for current research and development. These particularly include substances that rapidly exert clinical effects and have afavorable side-effect profile.

БРЕНД-МЕНЕДЖМЕНТ КОМПАНІЙ В ГЛОБАЛЬНОМУ КОНКУРЕНТНОМУ СЕРЕДОВИЩІ

This article is devoted to defining the growing role of brand management in companies in the context of intensifying competition in the international markets of goods and services. The turbulence of the marketing environment creates a demand for increasing the efficiency of management technologies. One of the most effective tools in the international marketing activities of companies is brand management. The purpose of this article is to reveal the benefits and risks when companies use global brand management. To study this issue, a set of methods was used, including analysis and synthesis, empirical and statistical analysis; comparative analysis; and systematization. Based on the data of international research and consulting organizations, the article presents a quantitative measurement of certain aspects of the implementation of global brand management strategies. The result of the study is the disclosure of the content of competitive advantages achieved by companies when they choose a global branding strategy. Among the priorities are the following: increasing customer loyalty in the markets where the company operates; improving brand awareness and perception; improving the financial performance of an international company; improving the company's reputation; attracting and retaining talent. The factors that can complicate the implementation of global branding approaches include the persistence of differences in consumer and business cultures in different foreign markets, peculiarities in the institutional environment of different countries that affect the conditions of registration and legal mechanisms for protecting trademarks in different jurisdictions, a more positive perception of local brands of national businesses in the context of the intensification of new economic nationalism at the level of regulatory policies and consumer sentiment. The theoretical significance of the study is to expand knowledge about achieving a balance between global and local determinants that define the success of international companies in the context of increased competition in international markets for goods and services. The practical value is due to the search for new mechanisms to enhance the competitive position of domestic companies in global markets in the context of forced business relocation during the war between Ukraine and russia. Prospects for further research are seen in the systematization of empirical material and cases on the implementation of effective brand management strategies by domestic businesses in foreign expansion.

«Американские лекции» И. Кальвино как комментарий к романам «Невидимые города» и «Если однажды зимней ночью путник»

“American Lectures” (Six Memos for the Next Millennium) are well established in the minds of readers as a testament of Italo Calvino addressed to posterity. The course of lectures prepared by the writer for delivery at Harvard University in 1984 was the last work from his pen. In his last book, Calvino identifies several features of literature that are of particular value. Thanks to their mind-stimulating cognitive functions, these features, according to the writer, will help future generations cope with the dangers that are inherent in the language of media with its vague concepts and in visual promotional images that clog our imagination. “American Lectures” not only allow us to look at the history and theory of literature from an unexpected angle, but also shed light on Calvino’s own creative path. The reflections contained in the lectures are primarily related to the search for new mechanisms for creating a literary work, which occupied the writer in his last, “combinatorial”, period. In his lectures, Calvino reflects on speed, which is equivalent to agility, mobility, ease of storytelling, which above all are characteristic of oriental fairy tales. Calvino’s novels Invisible Cities and If on a Winter’s Night a Traveler are like The Thousand and One Nights thanks to a frame composition capable of accommodating a potentially infinite number of inserted short stories. As in The Thousand and One Nights, in the novel Invisible Cities the plot of the frame is built on the relationship between the narrator and the ruler. By contrast, in If on a Winter’s Night a Traveler the engine of the plot is the art, borrowed from Scheherazade, of interrupting the story at the climax of the unfolding plot. In addition, according to the ideas contained in the lectures, a large form made up solely of beginnings actualizes the potential of the novel as a genre that concentrates its power precisely at the beginning of the narrative. Both novels considered here are in line with the writer’s experiments with the form of “map-novel” or “hyper-novel”, capable of accommodating a potentially unlimited number of images and plot combinations.

Новая роль кооперации в условиях экономических санкций: оценки жителей Калининградской области

The current economic crisis conditions call for a search for new mechanisms to maintain the population’s well-being. Within this setting, cooperation may be considered a priority form of entrepreneurial activity, enabling the consolidation of financial resources and reducing business costs. This article aims to assess the potential of consumer cooperation in the Kaliningrad region under anti-Russian sanctions. The authors analyse the features of cooperation development within the territory and investigate the demands and expectations of the local populace. The principal method employed in the study is a survey of residents of the Kaliningrad region (N = 481), with its results strongly indicating that conditions for a renaissance of cooperative economic models have emerged in the Russian exclave. The region’s residents tend to express positive attitudes towards cooperation, drawing a link between economically challenging conditions and opportunities for cooperative development. Moreover, amongst respondents with personal or vicarious experience of cooperation, a substantially higher proportion assess cooperative practices positively. Yet, the deficit of interpersonal trust places a serious limitation on the development of cooperation. It is concluded that the economic crisis has shifted the focus of the region’s population’s expectations from social interests (collaborations with like-minded individuals) to undertakings aimed at increasing material well-being. Therefore, expectations of participating in cooperative activities are primarily associated with the opportunity to start one’s own business and increase personal income.

DETEСTION OF miRNA IN CHRONIC PERIODONTITIS CLINICAL STUDIES: A SYSTEMATIC REVIEW

There is a list of limitations for accurate clinical assessment of chronic periodontitis (CP) activity. The search for new mechanisms of pathogenesis leads to the selection of appropriate test substrates and research methods. Today, a number of miRNAs are known, which are involved in maintaining a healthy state or periodontal diseases. The aim of this systematic review was to analyze researches devoted to the role of miRNA in chronic periodontitis and various research methods to clarify the further study. Materials and methods. We followed PRISMA guidelines to conduct this systematic review. To identify the types of miRNAs, and their research methods in CP, PubMed database were systematically screened for medical literature. The articles published from 2019 up to November 27, 2023, were included. The articles were screened by using the search strategy as "chronic periodontitis miRNA". Results. We identified 35 miRNAs whose expression was significantly altered in chronic periodontitis (CP) compared to healthy gingiva. Fifteen of these miRNAs were correlated with the clinical manifestations of CP. The studies differed in the RNA-containing substrates, which included crevicular fluid, saliva, blood plasma, or exosomes from these substrates, as well as gingival biopsies. Real-time reverse transcription-PCR was the final method used for miRNA identification in all the studies. miRNAs are involved in almost all cellular processes and play a crucial role in development, differentiation, and homeostasis. They achieve these functions indirectly by suppressing gene expression, particularly through the inhibition of translation at the initiation stage. Target genes associated with the pathogenesis of chronic periodontitis (CP) have been previously identified for some miRNAs. Conclusion. Among the studied miRNAs, there are promising candidates to become targets for correction to optimize treatment, especially considering their predicted or known target genes involved in the pathogenesis of chronic periodontitis. However, no study has been devoted to pharmacological corrections of altered miRNA expression in chronic periodontitis.

ANTIOXIDANTS SUPPLEMENTATION BASED ON NATURAL PRODUCTS IN THE TREATMENT OF THE THERMAL SKIN INJURY

Thermal injuries are a major medical, economic and social problem, whose severity, morbidity, mortality, prognosis and treatment outcome directly depend on the surface and depth of the burn, but also on the patient's age, health status and accompanying complications. The treatment of thermal injury is long and complex, and the outcome is often uncertain with a very complex rehabilitation process, because the injury damages both physical and psychological health. Constant innovations in the protocol of medical treatment and the search for new mechanisms involved in the pathogenesis of burns can be helpful in successful treatment. Therefore, there is a constant search for adjuvant therapies that will improve results like HBO, AO, platelet- rich plasma, negative pressure wound therapy and others. In recent years, the application of antioxidants as adjuvant therapy for the care and treatment of wounds has been the subject of various researche. Antioxidants are biologically active molecules that prevent the creation of free radicals in the body and at the same time neutralize the existing ones, this way participating in maintaining the oxidative status at the desired level. Antioxidant -rich natural products may provide a solution to improve wound healing. The application of antioxidant therapy has shown numerous benefits in improving the outcome of burns. However, more information is needed from the clinical trials on the use of natural products, especially in combination with other therapies. Keywords: thermal skin injury, hyperbaric oxygen therapy, antioxidant rich natural products

The modern mechanisms of integration of medical organizations in health care system

The article considers mechanisms of cooperation of medical organizations of various forms of property, intersectoral interaction with purpose to unify resources of organizations to resolve established tasks, to form large medical clusters and to organize interaction of medical organizations with recreation structures. The actuality of issue is conditioned by the fact that population health is the most important value of society. This value is ultimate condition of prosperity and well-being of any state and depends on quality of medical care and efficiency of functioning of medical care system. In many countries occurs search for new mechanisms permitting to increase quality of medical care and its accessibility. The issues of interaction private sector with state system of financing of health care and state medical organizations, including development of integration mechanisms in health care system with private medicine potentials to update health care system is agenda priority. The purpose of the study is to consider modern mechanisms of integration of organizations in health care system and practical involvement into action.

PUBLIC WORK POLICIES AND PROFISSIONAL QUALIFICATION IN BRASIL AND IN MARANHÃO: A STUDY BETWEEN THE YEARS FROM 2008 TO 2017

This study aims to analyze the public labor policies adopted in the State of Maranhão and the challenges faced by the government to promote state growth and development over the period of time from 2008 to 2017, as well as how to characterize the economic trajectory over the years related indices to work in the indicated period, in addition to the years of professional qualification linked to public work policies in the State. In Brazil, the multifunctional profile of its workers was not compatible with market demand, where workforce rationalization strategies predominated, based on the search for new mechanisms to reduce costs, overtime, salaries, and flexibility and relationships. trabalhistas. In this way, this research is characterized, methodologically, as quantitative and descriptive, of a bibliographic and documentary nature. It is highlighted that, in the State of Maranhão, during the period studied (2008 to 2017), despite two efforts undertaken by the government to implement public policies on labor and professional qualification, the initiatives adopted are still not effective and efficient to solve or problem of employment and income management and economic growth of the State.

ВПРОВАДЖЕННЯ СИСТЕМ РЕСУРСОЗБЕРЕЖЕННЯ НА ПІДПРИЄМСТВАХ ГОТЕЛЬНОГО ГОСПОДАРСТВА УКРАЇНИ

The article deals with the implementation of resource saving systems at hotel enterprises. The main obstacles on the way to the introduction of resource-saving technologies in Ukraine are indicated and actual ways to solve them are proposed. The problems of resource conservation and ensuring energy efficiency are relevant for Ukrainian hotels in connection with a significant increase in the cost of hotel services due to a significant volume of electricity use and a rapid increase in energy prices. In Ukraine, resource-saving technologies are just beginning their development. Basically, resource saving systems are implemented by hotels belonging to international hotel chains. Currently, the majority of foreign hotel enterprises strive to participate in international environmental programs, which make the use of non-traditional sources of heat and energy relevant. In addition, in recent years, the population, especially within the framework of the European space, has become more environmentally responsible. Therefore, environmental responsibility in business also serves as an effective tool for creating a positive image of the enterprise, increasing the occupancy of the number pool and, as a result, increasing profits. Proposed important measures that can be implemented in hotel enterprises for the purpose of saving resources, which will make it possible to accelerate the scientific search for new mechanisms for reforming the industry, to develop new concepts and management methods, because in the conditions of constant variability of both the internal and external environment, the hotel business is always faced with new problems and challenges. The effectiveness of implementation of scientific developments will provide Ukrainian business with a worthy place in the world market of the hospitality industry, will increase its significance for the growth of the national economy and international integration, in particular in the European direction.

SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF-β1

Cardiac fibroblasts (CFs) activation is a common response to most pathological conditions affecting the heart, characterized by increased cellular secretory capacity and increased expression of fibrotic markers, such as collagen I and smooth muscle actin type alpha (α-SMA). Fibrotic activation of CFs induces the increase in tissue protein content, with the consequent tissue stiffness, diastolic dysfunction, and heart failure. Therefore, the search for new mechanisms of CFs activation is important to find novel treatments for cardiac diseases characterized by fibrosis. In this regard, TGF-β1, a cytokine with proinflammatory and fibrotic properties, is crucial in the CFs activation and the development of fibrotic diseases, whereas its molecular targets are not completely known. Serum and glucocorticoid-regulated kinase (SGK1) is a protein involved in various pathophysiological phenomena, especially cardiac and renal diseases that curse with fibrosis. Additionally, SGK1 phosphorylates and regulates the activity and expression of several targets, highlighting FoxO3a for its role in the regulation of oxidative stress and CFs activation induced by TGF-β1. However, the regulation of SGK1 by TGF-β1 and its role in CFs activation have not been studied. In this work, we evaluate the role of SGK1 in CFs isolated from neonatal Sprague-Dawley rats. The participation of SGK1 in the fibrotic activation of CFs induced by TGF-β1 was analyzed, using an inhibitor or siRNA of SGK1. In addition, the role of SGK1 on the regulation of FoxO3a and oxidative stress induced by TGF-β1 was analyzed. Our results indicate that TGF-β1 increased both the activity and expression of SGK1 in CFs, requiring the activation of MAPKs, ERK1/2, p38 and JNK, while inhibition and silencing of SGK1 prevented TGF-β1-induced fibrotic activation of CFs. In addition, SGK1 inhibition prevented FoxO3a inactivation and expression reduction, catalase and SOD2 expression decrease, and the increase of oxidative stress induced by TGF-β1. Taken together, our results position SGK1 as an important regulator of CFs activation driven by TGF-β1, at least in part, through the regulation of FoxO3a and oxidative stress.

FORCED RESETTLEMENT AS A FACTOR OF DEVIANT BEHAVIOUR OF CHILDREN AND ADOLESCENTS IN THE MULTICULTURAL ENVIRONMENT

The relevance of the publication is determined by military challenges that negatively affect people’s behaviour. The risk group consists of children and adolescents who, due to the military conflict, had to adapt to new, unusual conditions due to a change of residence. Despite the efforts of authorities at all levels, volunteers, the community, and benefactors to support and create acceptable living conditions for internally displaced persons, the process of adaptation to new realities of life, a multicultural society, and a different educational environment remains painful. The purpose of the article is to analyze the main reasons for the deviant behaviour of children and adolescents, to find out the impact of forced relocation in the conditions of war on deviance in minors; justify the importance of the organization of the educational environment, taking into account the multiculturalism of the students of education. Analytical methods were used in the research to find and select modern studies on the impact of war on children and adolescents, to analyze the domestic and foreign experience of preventing deviant behaviour of immigrants, synthesis of scientific ideas and their structuring. The ideas of scientists and own pedagogical experience were summarized, the results were interpreted, and conclusions were drawn. The deviant behaviour of children and adolescents in the conditions of forced resettlement becomes an obstacle to full socialization in a multi-ethnic society, and therefore requires the search for new mechanisms and means of prevention. An educational environment saturated with multicultural content and values is defined as an effective means of preventing deviant behaviour. In a multicultural educational environment, tolerance plays the role of a universal tool for the interaction of speakers of different cultures.

ОСОБЕННОСТИ УПРАВЛЕНИЯ ВНЕШНЕЭКОНОМИЧЕСКОЙ ДЕЯТЕЛЬНОСТЬЮ КОМПАНИЙ РОССИИ В УСЛОВИЯХ ЭКОНОМИЧЕСКОЙ ТУРБУЛЕНТНОСТИ

The quality of regulation of foreign economic activity (hereinafter referred to as foreign economic activity) in conditions of instability is endowed with certain specifics, the source of which is the limited capabilities of the state, both financial and physical. The current situation and the complexity of the newly formed circumstances in Russia necessitates the search for new mechanisms to influence foreign trade, as well as ways to rationally combine tools to stimulate and deter international trade activity of the state. However, at present, all the complexity of foreign trade regulation is associated with the need to preserve the profitability of the state on the world market, as well as maximize budget revenues in conditions of limited opportunities for business development and the functioning of the domestic economy. In this case, one of the main tools for ensuring the implementation of the state foreign economic policy is the legal field, the complexity of which lies in their evolutionary nature of development and constant change, including in conditions of economic turbulence. The purpose of the article is to assess the regulation of foreign economic activity in the conditions of turbulence of the domestic economy, as well as transformations taking place in the strategy for the implementation of foreign economic policy. To achieve this goal, the authors have formed and solved tasks, the main among which was the assessment of transformation indicators in the mechanism of regulation of foreign economic activity, as well as the prospects for the development of foreign economic activity in Russia.

Technological challenges in the economy of the oil and gas sector

Technological challenges related to the “green” economy, digitalization of business processes, and intelligent manufacturing affect all sectors of the global economy. The oil and gas complex has a complexly organized production process, while the oil industry depends on the volatility of coal prices and the general decline of the world economy. In this regard, it is important to analyze the current state and propose environmental, technological, financial and economic measures to minimize the impact of scientific, technological, and financial risks on the companies’ technological integration. Oil and gas companies of the Russian Federation and the Republic of Kazakhstan were selected as the object of the study. In order to overcome the technological lag, increase the depth of processing of raw materials at enterprises, a search for new mechanisms was initiated through the development of the institute of stakeholder relations and the improvement of the scientific and technological risk management system. The study revealed that the combination of the advantages of internal and external growth contributes to the increase of the innovative potential of oil and gas companies. It is an important incentive when concluding transactions to combine the capital of related industries, support the education system, cultural traditions of the population in the regions of the presence of oil, gas, oil refining and petrochemical companies. An open system of “corporate integration spaces”, the innovativeness of the integration strategy, the knowledge economy, and the intellectualization of production were used as the elements of the concept of technological challenges mitigation. There is emphasized high importance of artificial intelligence in the management system of the oil industry economy.

Ukrainian Book Market as a Factor of National Security in the Context of russia’s Armed and Information Aggression

The purpose of the article is to consider the main challenges and problems associated with the formation of the Ukrainian book market in the context of the escalating war with Russia and to analyze its functioning as an important factor of national and human security.
 The research methodology is based on the method of modelling, which involves a comprehensive study of the book market as a set of interactive and interdependent (market and non-market) components that form an integrated whole; the method of synergetic research, which explains linear and nonlinear options for the formation of the book market, fixes bifurcation points, takes into account their main challenges and threats; the system-communication method, the use of which makes it possible to clarify the specifics and opportunities for the development of publishing and book distribution in Ukraine in a complex system of information and cultural communications at the present stage.
 The scientific novelty of the research is as follows: substantiation of the understanding of the Ukrainian book market as an essential factor of national and human security in the context of the main challenges and threats as of 2022, the need to regulate it, create favourable conditions for the growth of the publishing industry and promote the culture of reading in Ukraine.
 Conclusions. For a long time, the sphere of publishing and book business did not have proper attention from the state. There was a robust expansion of Russian publishing products into the cultural space of Ukraine. The Russian-Ukrainian war became a powerful catalyst that changed the state of affairs in the book market. It has been emphasized that legislative initiatives and institutional transformations of recent years have contributed to the quality indicators improvement of the Ukrainian publishing industry. Despite the positive statistics, the search for new mechanisms to counteract the Russian cultural expansion, which results in the military occupation, the impossibility of penetration and distribution of Russian-language printed products on the territory of Ukraine, remains urgent.

«Соглашение о лояльности» как новелла российского миграционного права

Introduction. The Russian Federation is in constant search for new mechanisms to improve the efficiency of the state migration policy. At the same time, the liberalization of migration legislation was chosen as the main vector of transformations, while unconditionally ensuring public safety and observance of national interests. “Loyalty agreement” is a novelty designed to try out the state, public and individual interests of the subjects of migration relations. Theoretical analysis. The legal nature of the institution of “loyalty agreement” is being analyzed. The international functioning of similar institutions is investigated in order to make a conclusion on the possibility of its implementation in the Russian legal reality. Result. The author reached the conclusion about the auxiliary nature of the institution of “loyalty agreement”. It is proposed to consider the “loyalty agreement” as a kind of public “offer” – the proposal of the Russian Federation to enter its territory and stay on the territory provided that the essential conditions for compliance with the law are met. It is noted that, along with the «loyalty agreement», it is necessary to consolidate the institutional conditions for “immigration supervision”, mechanisms for ensuring the special immigration status of “controlled stay” in a single regulatory legal act.

Contribution of International Non-Governmental Organizations to Peaceful Conflict Resolution Processes: The Case of the Syrian Conflict

Due to the increase in the number of conflicts, which lead to the growth of tension and destabilization of the system of international relations, the search for new mechanisms for their settlement and new participants who are able to introduce a positive agenda through interaction with all parties is an urgent research task. This paper focuses on international non-governmental organizations (INGOs), acting as such new actors and taking part in the settlement of the conflict in Syria. The purpose of the article is to analyze their contribution to the Syrian peace process, to consider their possibilities and limitations. The methodology is based on discourse analysis and case studies. The case of Syria was chosen because of the ongoing nature of the civil war there, as well as the fact that INGOs have proposed a number of new initiatives to resolve the conflict, which makes this study novel. The study identified the main organizations that propose a peaceful settlement of the conflict, and also identified the main trends in the participation of INGOs in the crisis settlement in Syria. Thus, participating in the peace process, they also implement peacebuilding projects, actively cooperate with local INGOs, and switch to remote work formats due to security problems. However, the analysis of their proposals for the peace process also revealed the main problems of the activities of INGOs within the framework of track II diplomacy, which consist in their neglect of the principle of impartiality. The ability of INGOs to promote their initiatives is also influenced by the dynamics of traditional diplomacy. The key takeaway is that, despite the complexity of the Syrian peace process and the dominant role of traditional diplomacy, INGOs have a significant positive impact on the peace process as they promote grassroots cohesion among the Syrian population and encourage them to form civil associations similar to INGOs, which are also gradually beginning to look for ways of national reconciliation.

A Novel Method for Developing Post-quantum Digital Signature Algorithms on Non-commutative Associative Algebras

Introduction: Development of practical post-quantum signature algorithms is a current challenge in the area of cryptography. Recently, several candidates on post-quantum signature schemes, in which the exponentiation operations in a hidden commutative group contained in a non-commutative algebra is used, were proposed. Search for new mechanisms of using a hidden group, while developing signature schemes resistant to quantum attacks, is of significant practical interest. Purpose: Development of a new method for designing post-quantum signature algorithms on finite non-commutative associative algebras. Results: A novel method for developing digital signature algorithms on non-commutative algebras. A new four-dimensional finite non-commutative associative algebra set over the ground field GF(p) have been proposed as algebraic support of the signature algorithms. To provide a higher performance of the algorithm, in the introduced algebra the vector multiplication is defined by a sparse basis vector multiplication table. Study of the algebra structure has shown that it can be represented as a set of commutative subalgebras of three different types, which intersect exactly in the set of scalar vectors. Using the proposed method and introduced algebra, a new post-quantum signature scheme has been designed. The introduced method is characterized in using one of the elements of the signature (e, S) in form of the four-dimensional vector S that is computed as a masked product of two exponentiated elements G and H of a hidden commutative group: S = B-1GnHmC-1, where non-permutable vectors B and C are masking multipliers; the natural numbers n and m are calculated depending on the signed document M and public key. The pair <G, H> composes a minimum generator systems of the hidden group. The signature verification equation has the form R = (Y1SZ1)e(Y2SZ2)e2, where pairwise non-permutable vectors Y1, Z1, Y2, and Z2 are element of the public key and natural number e that is computed depending on the value M and the vector R. Practical relevance: Due to sufficiently small size of public key and signature and high, the developed digital signature scheme represents interest as a practical post-quantum signature algorithm. The introduced method is very attractive to develop a post-quantum digital signature standard.

Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review.

Temporal lobe epilepsy (TLE) is one of the most common forms of focal epilepsy in children and adults. TLE is characterized by variable onset and seizures. Moreover, this form of epilepsy is often resistant to pharmacotherapy. The search for new mechanisms for the development of TLE may provide us with a key to the development of new diagnostic methods and a personalized approach to the treatment. In recent years, the role of non-coding ribonucleic acids (RNA) has been actively studied, among which microRNA (miR) is of the greatest interest. (1) Background: The purpose of the systematic review is to analyze the studies carried out on the role of miRs in the development of mesial TLE (mTLE) and update the existing knowledge about the biomarkers of this disease. (2) Methods: The search for publications was carried out in the databases PubMed, Springer, Web of Science, Clinicalkeys, Scopus, OxfordPress, Cochrane. The search was carried out using keywords and combinations. We analyzed publications for 2016–2021, including original studies in an animal model of TLE and with the participation of patients with TLE, thematic and systemic reviews, and Cochrane reviews. (3) Results: this thematic review showed that miR‒155, miR‒153, miR‒361‒5p, miR‒4668‒5p, miR‒8071, miR‒197‒5p, miR‒145, miR‒181, miR‒199a, miR‒1183, miR‒129‒2‒3p, miR‒143‒3p (upregulation), miR–134, miR‒0067835, and miR‒153 (downregulation) can be considered as biomarkers of mTLE. However, the roles of miR‒146a, miR‒142, miR‒106b, and miR‒223 are questionable and need further study. (4) Conclusion: In the future, it will be possible to consider previously studied miRs, which have high specificity and sensitivity in mTLE, as prognostic biomarkers (predictors) of the risk of developing this disease in patients with potentially epileptogenic structural damage to the mesial regions of the temporal lobe of the brain (congenital disorders of the neuronal migration and neurogenesis, brain injury, neuro-inflammation, tumor, impaired blood supply, neurodegeneration, etc.).

АЛЛОКАТИВНАЯ ЭФФЕКТИВНОСТЬ МОДЕЛЕЙ ОРГАНИЗАЦИОННО-ЭКОНОМИЧЕСКОГО МЕХАНИЗМА СФЕРЫ СОЦИАЛЬНЫХ УСЛУГ СЕЛЬСКИХ ТЕРРИТОРИЙ

In the context of the challenges of the neoindustrial stage of the economy, the problem of priority development of human capital industries, the search for new mechanisms to ensure high quality of their growth is being actualized. This problem is particularly acute in relation to the population of rural areas, which are significantly inferior to the city in terms of quality of life. The purpose of this study is to determine the allocative efficiency of social service producers in rural areas, and then compare these indicators with the expansion of the non-state sector of social service producers. The study is based on the methodology for assessing the effectiveness of models for the development of social services, which differ in the nature of the allocation of public resources and the degree of participation of the state, private entrepreneurs and non –profit organizations as alternative participants in the organizational and economic mechanism for providing social benefits. A methodology for assessing allocative efficiency is proposed to justify ways to adapt the development of social services in rural areas to modern conditions. The results of the study show that mainly allocative efficiency is characteristic of the subjects of the public sector and the sphere of social services. These subjects form a larger output with the same attracted resources, which is a key constraint in attracting commercial and nonprofit organizations to the social sphere. The low allocative efficiency of non-state producers of social services explains the lack of proactive development of commercial and non-commercial entities in the field of social services and the corresponding growth in the output of social services by these producers.

ЗАКОРДОННИЙ ДОСВІД ДЕРЖАВНОГО РЕГУЛЮВАННЯ ІННОВАЦІЙНОЇ ДІЯЛЬНОСТІ НА ПРОМИСЛОВИХ ПІДПРИЄМСТВАХ КИЇВСЬКОЇ ОБЛАСТІ

Introduction. Unfavorable trends in the development of the domestic economy in recent years require the search for new mechanisms to stimulate the national economy in a period of structural change that can intensify the innovative activities of industrial enterprises in the Kiev region. This also applies to issues of foreign experience in the operation of special forms of organization of innovation, such as technopolises, technology parks, clusters, industrial parks and more. The issue of state regulation of their activities deserves special attention. In order to increase the measures of the state innovation policy, it is expedient to implement the positive experience of innovative development of enterprises in Ukraine, taking into account local peculiarities of creation and development of enterprises on an innovative basis. Materials and methods. The information base of the study consisted of statistical materials, regulations, national programs for enterprise development on an innovative basis. Positive experience in the implementation of regulations in the field of innovation development of enterprises can potentially be used in Ukraine, which will promote the intensification of special forms of organization of innovation. Results and discussion. The study found that in the countries there are several main determinants of the formation of innovative enterprises: the concentration of competitive enterprises in the region; availability of competitive advantages for the development of enterprises on an innovative basis; geographical concentration and proximity to settlements. Unlike other countries in Ukraine, there are factors that hinder the development of innovative enterprises. In this regard, it is necessary to develop proposals to improve the regulatory framework for the creation and development of innovative enterprises in the industrial sector; to implement state programs to promote the development of enterprises on an innovative basis; develop innovative connections and networking collaborations; to attract credit funds from international financial organizations on program principles, etc. Conclusions. Based on the study of the peculiarities of innovative development of enterprises in other countries, proposals have been developed to intensify innovative activities in Ukraine. In particular, proposals have been developed for the activities of special forms of organization of innovation activities, such as clusters and industrial parks. A significant achievement is the development of proposals to introduce a mechanism of public-private partnership in industrial enterprises in Ukraine, taking into account the experience of the world.