The object of research is the effect of gamma radiation on the characteristics of the operation amplifier, and consequently the behavior of the output voltage waveforms of Schmitt trigger circuit. One of the most problematic is the effect of the circuit elements, reference voltage, input frequency, input DC-voltage and bias voltage effects, on the operation of the proposed Schmitt trigger circuit. In the course of the research, the used Op Amp can be exposed to different types of radiation. As a result of the research it is shown that the threshold levels of Schmitt trigger circuit increased when operates in nuclear radiation environment.From the experimental work, computer simulation, and results analysis, the conclusions could be deduced, that Operation of operational amplifiers in gamma radiation environment show serious changes on their electrical characteristics. As a result, the Schmitt trigger circuit exposed to gamma radiation range from 3 kGy up to 20 kGy, at 10 Hz, where, its output voltage waveforms are shown to be independent on the gamma-dose. On the other hand, at frequency of 4.0 kHz, a severe effect are noticed, where the lower threshold level (VLTL) increase from –5.35 V up to –3.58 V, while the upper threshold voltage level (VUTL) is slightly increased from 4.21 V to 5 V, as a function of the same gamma doses. The obtained experimental results are shown to be in close agreement with those obtained from programming the Schmitt trigger equations to computer.In the future, the proposed approaches show that, whenever the Op Amp circuits are used in gamma radiation environment, it preferable to be operate at low frequency levels, where the output voltage waveform of Schmitt trigger circuit are shown to be independent on gamma dose but at high frequency the effect increased as a function of same gamma dose.