At present, new acrylic plastic technologies are being developed in dentistry. Although this kind of material has been used for dental prostheses for over 80 years, it has been produced in the form of disks with the computer-aided design/computer-aided manufacturing (CAD/CAM) technology for over 15 years. The purpose of the article was to collect information from the literature on acrylic materials processed through the milling technology (CAD/CAM). The publicly available databases PubMed, Google Scholar and Scopus were searched using the key word "acrylic resins, CAD/CAM". All articles describing the application and testing of CAD/CAM disks were selected. Duplicate articles were removed. More than 100 articles that described the use of materials machined using the milling equipment were found. These included works comparing the mechanical properties, biocompatibility and clinical use of the materials. After the initial selection, 36 papers on this subject were included in this review. The number of studies on the processing of acrylic materials with the use of the CAD/CAM technology has been increasing worldwide. Since such materials have better mechanical properties, no polymerization shrinkage occurs during processing, the amount of residual monomer material is very low and they have better color stability than self-curing materials.