Abstract
The automated dialysis of polymers in synthetic robots is described as a first approach for the purification of polymers using an automated protocol. For this purpose, a dialysis apparatus was installed within a synthesis robot. Therein, the polymer solution could be transferred automatically into the dialysis tube. Afterwards, a permanent running dialysis could be started, enabling the removal of residual monomer. Purification efficiency was studied using chromatography and NMR spectroscopy, showing that the automated dialysis requires less solvent and is faster compared to the classical manual approach.
Highlights
The ongoing digitalization has been significantly influencing chemical research over the last few years [1]
The automated dialysis setup was constructed using a standard 250 mL bottle and a special Teflon cap enabling the injection via the four-needle head of the robot (Figure 1 and Supplementary Materials)
The working principle and effectiveness can be studied in detail
Summary
The ongoing digitalization has been significantly influencing chemical research over the last few years [1]. One major aspect in this field is the automation of chemical processes [2], and associated with that, the high-throughput synthesis of compounds [3,4]. For this purpose, flow-chemistry [5]/microfluidics [6,7,8,9] as well as robot-based synthesis can be performed, enabling a fast and more efficient screening of chemical reactions and processes. The modern tools in such robotic systems enable nearly a complete investigation of all compounds such as liquids, solids, and gases. Reactions can be performed in multiple fashions by applying different reaction parameters, e.g., temperature, pressure
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