In the last several years, the degradation of natural areas has been occurring at an alarming proportion. Open spaces that provide habitats to different life forms are being degraded because of improper management practices, contamination, and the desire to sustain societal needs for housing, transportation etc. In the process, habitat loss stands as one of the most significant threats to biodiversity and a major environmental problem facing society. In the literature, the loss, degradation and alteration of habitats are the primary factors responsible for the global disappearance of rare species of wild animals and plants. While some may assume that habitat destruction and loss of biodiversity are problems of species rich developing nations, it has become a serious problem in the United States (US). In the state of Mississippi, most of the bottomland hardwood forests and significant portions of thousands of acres of wetlands and streams have been degraded because of sedimentation and agricultural runoff fueled by intense farming activities. Notwithstanding previous mitigation measures, there has not been a substantial effort to examine these issues alongside current initiatives in habitat conservation in Mississippi. To fill that void, the paper examines the issues in wildlife habitat conservation as well as current initiatives with emphasis on the trends and factors using mixscale methods built on integrated Geographic Information Systems (GIS) and descriptive statistics. On the one hand, the temporal profile from the results point to changes in the form of gains and declines in the Conservation Reserve Program (CRP) land areas with the Central and Northeast region outpacing the Southwest zones of the state coupled with degradation. On the other, GIS mapping of change, not only showed the concentration of vast natural areas dispersed statewide, but pinpointed clusters of habitats slated for restoration and mitigation. With changes attributed to unsustainable land use practices, policy lapses, limited education and poor monitoring, community efforts remain in high gear among stakeholders to ensure habitat protection. Accordingly, the paper proffered solutions based on the need for conservation, adherence to best management practices, education and support for local participation.