Proper Growth Research Articles

Assessment of the Nutritional Status of Adolescents in Orphanage from Lahore, Pakistan

Orphans are one of the most vulnerable groups to nutritional deficiency, which require more nutritional care for proper growth and development. Assessment of nutritional status has cornerstone importance in orphans because growth retardation is mainly caused by undernutrition. As United Nations indicated in a recent report, there are more than 4.3 million orphan children in Pakistan and many of them are under age nearly of 17. The study aims to assess adolescent’s nutritional status and the relationship between BMI and their dietary habits. The current study is a cross-sectional study conducted on 80 orphan children aged (10-19 years). The sample of orphan children was taken from three orphanages in Lahore via non-probability convenient sampling. The data was collected using a questionnaire that included questions related to anthropometric measurements, clinical assessment, and food frequency tables. Data were analyzed by using SPSS software version 25. The frequency of orphans with normal BMI was 51.2% among the study sample. Indicatively, majority of children were suffering from paleness and dryness of skin, white spots in nails, redness in eyes, dry and brittle hair, and discolored or spongy gums. Dietary history showed that consumption of bread and cereals, starchy vegetables, junk food, and carbonated beverages was more common among orphanages. Orphan children in diverse orphanages had sub-clinical nutritional deficiencies due to poor dietary habits; emphasizing the need for detailed assessment of nutritional status in orphanages for the applications of related interventions to prevent nutritional deficiencies.

Sugar signals pedal the cell cycle!

Cell cycle involves the sequential and reiterative progression of important events leading to cell division. Progression through a specific phase of the cell cycle is under the control of various factors. Since the cell cycle in multicellular eukaryotes responds to multiple extracellular mitogenic cues, its study in higher forms of life becomes all the more important. One such factor regulating cell cycle progression in plants is sugar signalling. Because the growth of organs depends on both cell growth and proliferation, sugars sensing and signalling are key control points linking sugar perception to regulation of downstream factors which facilitate these key developmental transitions. However, the basis of cell cycle control via sugars is intricate and demands exploration. This review deals with the information on sugar and TOR-SnRK1 signalling and how they manoeuvre various events of the cell cycle to ensure proper growth and development.

Advances in fast 4H–SiC crystal growth and defect reduction by high-temperature gas-source method

This paper reviews recent progress in the development of high-speed 4H–SiC bulk crystal growth technology using the high-temperature gas-source method (high-temperature chemical vapor deposition). Vertical-type reactors capable of growing SiC bulk crystals of 50–75 and 100–150 mm in diameter have been developed, as have reactor configurations and growth conditions to achieve a high growth rate and material quality. Using the reactors, high growth rates up to or exceeding 3 mm/h have been achieved by employing an H2–SiH4–C3H8 gas system with high partial pressures of source gases and high growth temperature of 2500–2550 °C. It is also confirmed that the dislocation densities decline significantly in the direction of growth under proper growth conditions. Key factors for enhancing growth rate and improving crystal quality in the growth process are discussed.

Challenges to the delivery and utilisation of child healthcare services: a qualitative study of the experiences of nurses and caregivers in a rural district in Ghana

BackgroundSub-Saharan Africa has one of the poorest child health outcomes in the world. Children born in this region face significant health challenges that jeopardise their proper growth and development. Even though the utilisation of child healthcare services safeguards the health of children, the challenges encountered by nurses in the delivery of services, and caregivers in the utilisation of these services, especially in rural areas, have contributed to poor child health outcomes in this region.AimThis study explored the experiences of nurses and caregivers in respect of the nursing human resource challenges to the delivery and utilisation of child healthcare services in a rural district in Ghana.MethodsIndividual qualitative interviews were conducted with ten nurses, who rendered child healthcare services; nine caregivers, who regularly utilised the available child healthcare services; and seven caregivers, who were not regular users of these services. These participants were purposively selected for the study. Data were collected using individual semi-structured interview guides and analysed qualitatively using content analysis. Themes and sub-themes were generated during the data analysis. The Ghana Health Service Research Ethics Review Committee and the Nelson Mandela University’s Research Ethics Committee approved the study protocol prior to data collection.ResultsThree main themes emerged from the data analysis. Theme One focused on the shortage of nurses, which affected the quality and availability of child healthcare services. Theme Two focused on inexperienced nurses, who struggled to cope with the demands related to the delivery of child healthcare services. Theme Three focused on the undesirable attitude displayed by nurses, which discouraged caregivers from utilising child healthcare services.ConclusionNurses contribute significantly to the delivery of child healthcare services; hence, the inadequacies amongst nurses, in terms of staff numbers and nursing expertise, affect the quality and availability of child healthcare services. Also, caregivers’ perceptions of the quality of child healthcare services are based on the treatment they receive at the hands of nurses and other healthcare workers. In this respect, the bad attitude of nurses may disincentivise caregivers in terms of their utilisation of these services, as and when needed. There is an urgent need to comprehensively address these challenges to improve child healthcare outcomes in rural areas in Ghana. Relevant authorities should decentralise training workshops for nurses in rural areas to update their skills. Additionally, health facilities should institute proper orientation and mentoring systems to assist newly recruited nurses to acquire the requisite competences for the delivery of quality family-centred care child healthcare services.

Restoration of Kano Metropolitan Built Environment’s Vegetative Enclaves

Kano metropolis has over the years witnessed constant redevelopment of green corridor and reserve urban spaces within residential spaces and along major route which spines into commercial and public buildings. This is due to the pressure of urban expansion of the built-up environment. However, these changes do not take into considerations the social, physical and economic factors as such; the redevelopment has altered the built-up areas affecting the relationship between man and his built environment. The study is aimed at restoration of Kano Metropolitan Built Environment’s Vegetative Enclaves as they generate urban patterns through the use of green spaces to induce proper urban growth. Data were collected from the six area councils that make up Kano metropolis and analyzed using seventeen (17) identified attributes on effect of vegetation on the built environment. Descriptive statistics such as Simple distribution frequency (SDF) and Mean weighted score (MWS) were used to analyze the data presented, while inferential statistics employed was relative satisfaction index which was used to rank the environmental scores. Findings showed that the urban open space features significantly affect the level of residents’ satisfaction. The RSI scores for the relatively impact of vegetation on Kano metropolis are on the significance rating (RSI: 0.70 – 0.74 to 0.60- 0.69 corresponding to “Low Impact” and “Less Impact” respectively for most of the attributes, while fewer attributes such as “improved urban environment, improved lively and enhance city image” are areas of significance “high impact” rating, with RSI (0.75 and above). The study recommends the implementation and adherence to strong urban growth management law within the Kano metropolis, as a measure for sustaining the degraded environment and impacts of rapid urban growth in Kano metropolis

Ethanol consumption during gestation promotes placental alterations in IGF-1 deficient placentas

Background During pregnancy, the placenta is an extremely important organ as it secretes its own hormones, e.g. insulin-like growth factor 1 (IGF-1), to ensure proper intrauterine fetal growth and development. Ethanol, an addictive and widely used drug, has numerous adverse effects during pregnancy, including fetal growth restriction (FGR). To date, the molecular mechanisms by which ethanol triggers its toxic effects during pregnancy, particularly in the placenta, are not entirely known. For this reason, a murine model of partial IGF-1 deficiency was used to determine ethanol alterations in placental morphology and AAH expression. Methods Heterozygous (HZ, Igf1+/- ) female mice were given 10% ethanol during 14 days as an acclimation period and throughout pregnancy. HZ female mice given water were used as controls. At gestational day 19, pregnant dams were sacrificed, placentas were collected and genotyped for subsequent studies. Results IGF-1 deficiency and ethanol consumption during pregnancy altered placental morphology, and decreased placental efficiency and aspartyl/asparaginyl β-hydroxylase (AAH) expression in placentas from all genotypes. No differences were found in Igf1, Igf2, Igf1r and Igf2r mRNA expression in placentas from all groups. Conclusions IGF-1 deficiency and ethanol consumption throughout gestation altered placental development, suggesting the crucial role of IGF-1 in the establishment of an adequate intrauterine environment that allows fetal growth. However, more studies are needed to study the precise mechanism to stablish the relation between both insults.

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Maintaining the continuous oxygen supply and proper cell growth before blood vessel ingrowth at the bone defect site are considerably significant issues in bone regeneration. Oxygen-producing scaffolds can supply oxygen and avoid hypoxia leading to expedited bone regeneration. Herein, first oxygen-producing calcium peroxide nanoparticles (CPO NPs) are synthesized, and subsequently, the various amounts of synthesized CPO NPs (0.1, 0.5, and 1 wt/v%) loaded in the scaffold composite, which is developed by simple physical blending of chitosan (CS) and polycaprolactone (PCL) polymers. To deliver the synergistic therapeutic effect, dexamethasone (DEX), known for its potential anti-inflammatory and osteogenic properties, is loaded into the nanocomposite scaffolds. The extensive physicochemical characterizations of nanocomposite scaffolds confirm the successful loading of CPO NPs, adequate porous morphology, pore size, hydrophilicity, and biodegradability. In vitro, biological studies support the antibacterial, hemocompatible, and cytocompatible (MG-63 and MC3T3-E1 cells) nature of the material when tested on respective cells. Field emission scanning electron microscopy and energy-dispersive x-ray spectroscopy confirm the successful biomineralization of the scaffolds. Scaffolds also exhibit the sustained release of DEX and efficient protein adsorption. This study revealed that a nanoengineered scaffold loaded with CPO NPs (PCL/CS/DEX/CPO 3) is a suitable candidate for bone tissue regeneration.

Minimum acceptable diet and associated factors among children aged 6–23 months in Ethiopia: a systematic review and meta-analysis

BackgroundTo ensure a child's full growth, health, and development during infancy and the early years, adequate nutrition is crucial. A crucial window of opportunity for ensuring children's proper growth and development through adequate eating exists during the first two years of life. According to the evidence of the efficacy of interventions, achieving universal coverage of optimal breastfeeding could prevent 13% of deaths in children under the age of 5 worldwide, and using complementary feeding methods appropriately would lead to an additional 6% decrease in under-five mortality.MethodsFrom several electronic databases, all published, unpublished, and gray literature was extracted and exported into EndNote version X20. For further analysis of the review, the retrieved data from the excel sheet were imported into the statistical software program Stata version. Metanalysis was used to determine the prevalence of MAD, and a random effects model was used to estimate the pooled prevalence of MAD. The DerSimonian-Laird Random effects model (REM) was used to combine the determinant factors from all qualifying papers for the meta-analysis, and the heterogeneity was independently assessed using a χ2 test, Q statistics, and matching I2 statistics. To retrieve the extent of publication bias, funnel plots were scattered and tested for asymmetry and, additionally, Egger’s test was computed with the user-written “meta bias” command in Stata (version 11) software. To end, sensitivity analyses with trim and fill were performed.ResultsThe pooled estimate of the overall prevalence of minimum acceptable diet in 16 studies in Ethiopia was 22% with (95% CI: 16, 28%) with a random effect model. However, eight papers were filled during trim and fill in order to counteract the small study effect. The overall filled pooled estimate was 7.9% with (95%CI: 11, 14.8%). Maternal education (primary and secondary) is 1.714 (95% CI 1.244,2.363) and 2.150(95% CI: 1.449,3.190), respectively, Ages of children with range of 12–17 months (2.158 (95% CI 1. 9,3.006) and 18–23 months 2.948(95% CI: 1.675,5.190)), Nutrition information ((1.883 (95% CI 1.169,3.032)) media exposure (1.778(95% CI: 1.396,2.265), and maternal knowledge (2.449 (95% CI 1.232, 5.027) were significantly associated with MAD.ConclusionThe pooled estimate of the overall prevalence of minimum acceptable diet in 16 studies in Ethiopia were low. Maternal education (primary and secondary), ages of child with range of 12–17 month and 18–23 months, mothers having nutrition information, mothers who have media exposure,and mothers having good knowledge were significantly associated with Minimum acceptable diet. The government, NGO, and other stakeholders should focus on improving Minimum acceptable diet among 6 to 23 months of children through promoting with mass media, focuses on nutrition council during critical contact point in health facility, and doing capacity building for the mothers/caregivers.

Occlusion and Nutrition after Peadiatric Prosthetic Treatment

Nutritional and well-balanced food intake is of utmost importance for children's proper physical development and growth. Changes in masticatory structures are likely to cause significant change in both children's and adult's diet. The aim of this study is to examine the occlusion and the intake of macronutrients in children who have undergone dental treatment and restoration of the teeth affected by caries and its complications with different types of aesthetic crowns.
 The study included 103 children, which are prosthetically treated with crown structures and divided into four age groups. The restoration of the occlusal balance after the completion of the prosthetic treatment was established by means of a new generation of digital recording system (OccluSense by Bausch, Germany). A 24-hour diary on consumed foods and liquids was taken from children and their parents. Data is analyzed and processed statistically.
 The obtained results in all studied diagrams showed an increase in the occlusal forces bilaterally in the distal areas of the dentition in the anterior-posterior direction. Protein and carbohydrate intake by the tested children corresponded to the recommended range of 15.2±3.7 E% and 46.6±7.8 E%. Increased fat intake of 38.1±7.5 E%, as well as fibre consumption below the recommended values (13.6 g to 18.6 g) have also been observed.
 Dental restoration of heavily damaged children's teeth using prosthetic dentistry methods provides the opportunity for a normal intake of the main macronutrients.

Ayurvedic Management of Anidra W. S. R. to Insomnia – A Review

Introduction: Mansik dosha tama and Sharirik dosha Kapha are the causes of nidra. Consequently, Anidra results from any because that lowers the body’s levels of Tama and Kapha guna. Vata-pitta vridhi is stated by Acharya Vagbhatta and Sushruta in Nidranasha in Ayurveda. Anidra is regarded as one of the Vatavyadhi Nanatmaja. The Trayopasthamba are defined as Ahara (meal), Nidra (sleep), and Bramhacharya (three supporting pillars). From now on, getting enough sleep is crucial for maintaining good health. Acharya Charaka has correctly said that appropriate and improper sleep determines happiness and misery, proper and improper growth, good strength and weakness, potency and sterility, wisdom and ignorance, and life and death for a person. Anidra is compared to insomnia in contemporary science. Modern medical professionals now recommend a variety of tranquillizers to treat sleeplessness. Materials and Methods: The Brihattrayi and its commentaries, the Laghutrayi, as well as other Ayurvedic and contemporary texts, provided information on Anidra (Insomnia). Results: Ayurvedic classics including Madhura-Snigdha Anna, Gramya-Audaka-Anupa Rasa, Shali-Godhuma Pishtanna, Dadhi, Ksheera, Madhya, and Sneha all discuss how to handle sleeplessness. Insomnia might also benefit from panchakarma treatments like Nasya, Utsadana, Shirodhara, Abhyanga, Udavartana, and Samvahana. Conclusion: These medications provide significant relief during the first few days of treatment, but long-term use and continuing use have negative side effects. Thus, an attempt is made to view Anidra’s Ayurvedic management.

Cooperation between two modes for DNA replication initiation in the archaeon Thermococcus barophilus.

Replication of DNA is highly important in all organisms. It initiates at a specific locus called ori, which serves as the binding site for scaffold proteins-either Cdc6 or DnaA-depending on the domain of life. However, recent studies have shown that the Archaea, Haloferax volcanii and Thermococcus kodakarensis could subsist without ori. Recombination-dependent replication (RDR), via the recombinase RadA, is the mechanism that uses homologous recombination to initiate DNA replication. The extent to which ori's use is necessary in natural growth remains to be characterized. In this study, using Thermococcus barophilus, we demonstrated that DNA replication initiation relies on both oriC and RDR throughout its physiological growth, each to varying degrees depending on the phase. Notably, a knockdown RadA mutant confirmed the prominent use of RDR during the log phase. Moreover, the study of ploidy in oriC and radA mutant strains showed that the number of chromosomes per cell is a critical proxy for ensuring proper growth and cell survival.

Specific fractionation of ginsenosides based on activated carbon fibers and online fast screening of ginseng extract by mass spectrometry

Ginseng is beneficial in the prevention of many diseases and provides benefits for proper growth and development owing to the presence of various useful bioactive substances of diverse chemical heterogeneity (e.g., triterpenoid saponins, polysaccharides, volatile oils, and amino acids). As a result, understanding the therapeutic advantages of ginseng requires an in-depth compositional evaluation employing a simple and rapid analytical technique.In this work, three types of surface-activated carbon fibers (ACFs) were prepared by gas-phase oxidation, strong acid treatment, and Plasma treatment to obtain CO2-ACFs, acidified-ACFs, and plasma-ACFs, respectively. Three prepared ACFs were compared in terms of their physicochemical characterization (i.e., surface roughness and functional groups). A separation system was built using a column with modified ACFs, followed by mass spectrometry detection to investigate and determine substances of different polarities. Among the three columns, CO2-ACFs showed the optimum separation effect. 13 strong polar compounds (12 amino acids and1 oligosaccharide) and 15 lesser polar compounds (ginsenosides) were separated and identified successfully within 4 min in the ginseng sample. The data obtained by CO2-ACFs-TOF-MS/MS and UHPLC-TOF-MS/MS were compared. Our approach was found to be faster (4 min vs. 36 min) and greener, requiring much less solvent (1 mL vs. 10.8 mL), and power (0.06 vs. 0.6 kWh). The developed methodology can provide a faster, eco-friendly, and more reliable tool for the high-throughput screening of complex natural matrices and the simultaneous evaluation of several compounds in diverse samples.

Ahara Vidhi Vidhana: Ayurvedic Concepts of Food Consumption and Their Relevance in the Modern Age

In the modern world, when everyone is focused on attaining their goals, people often forget their balanced dietary routines, which leads to a number of lifestyle disorders. The three basic pillars of Ayurveda are Ahara, Nidra and Brahmacharya Among these, Ahara has been placed first which shows it is important to maintain and sustain life. Food habits like excessive intake, high protein diet, spicy, oily, harmful combination together, taking food without analysing one’s Agnibala are leading causes for diseases. For achieving complete benefits of food, one should also follow certain rules as told in Ayurveda regarding what, when, where, and how the food should be consumed. In Vimansthana, Charakacharya explains about Aharavidhividhana are the foundation of dietetics, which indicates the method of taking Ahara, which is useful for mankind. Aim & Objectives – To elaborate such principle of Ayurveda known as Ahara Vidhi Vidhan and their relevance in the modern age. Materials and Methods - Different classical Ayurvedic texts, websites, journals and research articles were referred in above context. Discussion and conclusion - The time, place, quantity and manner of Ahara intake are necessary. Ahara taken in proper manner helps in the proper growth of the body on contrary if taken in improper manner leads to various diseases. Thus, Aharavidhividhana plays a significant task in both causation and curing of the disease. Nidanaparivarjana is considered to be the main line of treatment. Properly followed Aharavidhividhana keeps the body healthy and prevents the diseases.

Dietary proteins: from evolution to engineering.

Because of the indispensable amino acids dietary proteins are the most important macronutrients. Proper growth and body maintenance depends on the quantity and quality of protein intake and proteins have thus been most crucial throughout evolution with hominins living in quite diverse food ecosystems. Developments in agriculture and food science have increased availability and diversity of food including protein for a rapidly growing world population while nutrient deficiencies resulting in stunting in children for example have been reduced. Nevertheless, the developing world and growing population needs more protein of high quality - with around 400 million tons per annum estimated for 2050. In contrary, protein consumption in all developed countries exceeds meanwhile the recommended intakes considerably with consequences for health and the environment. There is a growing interest in dietary proteins driven by the quest for more sustainable diets and the increasing food demand for a growing world population. This brings new and novel sources such as algae, yeast, insects or bacteria into play in delivering the biomass but also new technologies such as precision fermentation or in vitro meat/fish or dairy. What needs to be considered when such new protein sources are explored is that proteins need to provide not only the required amino acids but also functionality in the food produced thereof. This review considers human physiology and metabolism in the context of protein intake from an evolutionary perspective and prospects on future protein production.

Sensing and regulation of C and N metabolism - novel features and mechanisms of the TOR and SnRK1 signaling pathways.

Carbon (C) and nitrogen (N) metabolisms are tightly integrated to allow proper plant growth and development. Photosynthesis is dependent on N invested in chlorophylls, enzymes, and structural components of the photosynthetic machinery, while N uptake and assimilation rely on ATP, reducing equivalents, and C-skeletons provided by photosynthesis. The direct connection between N availability and photosynthetic efficiency allows the synthesis of precursors for all metabolites and building blocks in plants. Thus, the capacity to sense and respond to sudden changes in C and N availability is crucial for plant survival and is mediated by complex yet efficient signaling pathways such as TARGET OF RAPAMYCIN (TOR) and SUCROSE-NON-FERMENTING-1-RELATED PROTEIN KINASE 1 (SnRK1). In this review, we present recent advances in mechanisms involved in sensing C and N status as well as identifying current gaps in our understanding. We finally attempt to provide new perspectives and hypotheses on the interconnection of diverse signaling pathways that will allow us to understand the integration and orchestration of the major players governing the regulation of the CN balance.

Assessing sequence variation, haplotype analysis and molecular characterisation ofaspartate kinase2(ask2) gene regulating methionine biosynthesis in diverse maize inbreds.

Traditional maize grain is deficient in methionine, an essential amino acid required for proper growth and development in humans and poultry birds. Thus, development of high methionine maize (HMM) assumes great significance in alleviating malnutrition through sustainable and cost-effective approach. Of various genetic loci, aspartate kinase2 (ask2) gene plays a pivotal role in regulating methionine accumulation in maize. Here, we sequenced the entire ask2 gene of 5394bp with 13 exons in five wild and five mutant maize inbreds to understand variation at nucleotide level. Sequence analysis revealed that an SNP in exon-13 caused thymine to adenine transversion giving rise to a favourable mutant allele associated with leucine to glutamine substitution in mutant ASK2 protein. Gene-based diversity analysis with 11 InDel markers grouped 48 diverse inbreds into three major clusters with an average genetic dissimilarity of 0.570 (range, 0.0-0.9). The average major allele frequency, gene diversity and PIC are 0.693, 0.408 and 0.341, respectively. A total of 45 haplotypes of the ask2 gene were identified among the maize inbreds. Evolutionary relationship analysis performed among 22 orthologues grouped them into five major clusters. The number of exons varied from 7 to 17, with lengthvarying from 12 to 495bp among orthologues. ASK2 protein with 565 amino acids was predicted to be in homo-dimeric state with lysine and tartaric acid as binding ligands. Amino acid kinase and ACT domains were found to be conserved in maize and orthologues. The study depicted the presence of enough genetic diversity in ask2 gene in maize, and development of HMM can be accelerated through introgression of favourable allele of ask2 into the parental lines of elite hybrids using molecular breeding.

The Effect of Oral Iron Supplementation/Fortification on the Gut Microbiota in Infancy: A Systematic Review and Meta-Analysis.

(1) Background: Iron is an essential metal for the proper growth and neurodevelopment of infants. To prevent and treat iron deficiency, iron supplementation or fortification is often required. It has been shown, though, that it affects the synthesis of gut microbiota. (2) Methods: This paper is a systematic review and meta-analysis of the effect of oral iron supplementation/fortification on the gut microbiota in infancy. Studies in healthy neonates and infants who received per os iron with existing data on gut microbiota were included. Three databases were searched: PUBMED, Scopus, and Google Scholar. Randomized controlled trials (RCTs) were included. Quality appraisal was assessed using the ROB2Tool. (3) Results: A total of six RCTs met inclusion criteria for a systematic review, and four of them were included in the meta-analysis using both the fixed and random effects methods. Our results showed that there is very good heterogeneity in the iron group (I2 = 62%), and excellent heterogeneity in the non-iron group (I2 = 98%). According to the meta-analysis outcomes, there is a 10.3% (95% CI: -15.0--5.55%) reduction in the bifidobacteria population in the iron group and a -2.96% reduction for the non-iron group. There is a confirmed difference (p = 0.02) in the aggregated outcomes between iron and non-iron supplement, indicative that the bifidobacteria population is reduced when iron supplementation is given (total reduction 6.37%, 95%CI: 10.16-25.8%). (4) Conclusions: The abundance of bifidobacteria decreases when iron supplementation or fortification is given to infants.

Oncogenic K-RasG12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.

Protein phosphatase 6 is a Ser/Thr protein phosphatase and its catalytic subunit is Ppp6c. Ppp6c is thought to be indispensable for proper growth of normal cells. On the other hand, loss of Ppp6c accelerates growth of oncogenic Ras-expressing cells. Although it has been studied in multiple contexts, the role(s) of Ppp6c in cell proliferation remains controversial. It is unclear how oncogenic K-Ras overcomes cell proliferation failure induced by Ppp6c deficiency; therefore, in this study, we attempted to shed light on how oncogenic K-Ras modulates tumor cell growth. Contrary to our expectations, loss of Ppp6c decreased proliferation, anchorage-independent growth in soft agar, and tumor formation of oncogenic Ras-expressing mouse embryonic fibroblasts (MEFs). These findings show that oncogenic K-RasG12V cannot overcome proliferation failure caused by loss of Ppp6c in MEFs.

Relationship between Nutrition and Development of the Jaws in Children: A Pilot Study.

Craniofacial growth and development have been shown to be influenced by various environmental factors that impact child development. This study aims to analyze the different patterns of feeding during early childhood, starting from birth, and assess the variability of nutrition during the first stage of childhood, along with the habits developed, to study their impact on jaw development. The study was conducted on a sample of twenty-five patients aged 3 to 5, following approval from the ethics committee of the Catholic University of Valencia. Informed consent was obtained from the fathers, mothers, and/or legal guardians, who were administered surveys on habits and diet. Cephalometric measurements within the parameters of ideal occlusion were subsequently taken. While previous studies examined this subject, the findings are challenging to evaluate. However, this study identified significant associations (p = 0.001) between clinical measurements and children's eating habits. The growth and development of the craniofacial cavity are influenced by multiple factors, including a child's diet and habits. Nonetheless, further research is required to determine whether diet can be considered a determining factor in proper jaw growth.

Application of Convolutional Neural Network ResNet-50 V2 on Image Classification of Rice Plant Disease

Rice is the most important crop in global food security and socioeconomic stability. A part of the world's population makes rice a food requirement but the problem is found that all rice varieties suffer from several diseases and pests. Therefore, it is necessary to ensure the quality of healthy and proper rice growth by detecting diseases present in rice plants and treatment of affected plants. In this study, the Convolutional Neural Network (CNN) algorithm was applied in classifying diseases on the leaves of rice plants by experimenting with several parameters and architecture to get the best accuracy. This study was conducted image classification of rice plant disease using CNN architecture ResNet-50V2 with data using preprocessing Augmentation. The test was conducted with three optimizers such as SGD, Adam, and RMSprop by combining various parameters, namely epoch, batch size, learning rate, and SGD and RMSprop optimizers. Division of image data with 70:30 ratio of training data and test data; 80:20; 90:10. From these results, it was found that Adam was the best optimizer in the 80:20 data division in this study with an accuracy level of 0.9992, followed by the SGD optimizer with an accuracy level of 0.9983, while the RMSProp optimizer was ranked third with an accuracy level of 0.9978.