Abstract Compound extreme climate events (ECEs) are increasingly recognized for their potential to exacerbate food insecurity risks beyond those posed by isolated events. The notion of ‘compound event’ encompasses not only co-occurring ECEs but also multiple ECEs across (different) growth stages (mECEs). The additional effects of these mECEs on crop yield, particularly considering various types of ECEs and regional scales, remain poorly understood. To close this knowledge gap, we consider droughts, pluvials, heatwaves, and coldwaves, and further identify which types of compound events have additional effects on winter wheat yield in France, using statistical methods and datasets encompassing 94 counties over a 68-year period. Our results indicate co-occurring drought heatwaves in summer and spring, along with co-occurring pluvial heatwaves and pluvial coldwaves in winter, have negative additional effects on yield compared with single ECEs. We further identify the types of mECEs that have intensified effects, with the majority showing negative effects on yield. Key interactions leading to intensified yield loss include droughts in winter or spring combined with summer co-occurring drought heatwaves, pluvials across multiple growth stages, pluvials combined with coldwaves, and the transition between droughts and pluvials, with the most severe anomaly attaining −17.2%. Coldwaves are the main ECE related to intensified yield increases, while their frequency is decreasing. Overall, this study stresses the interactions among ECEs on crop yield, and the identified types of mECEs could serve as foundational information for designing control experiments and improving process-based crop models.