With the development of laser technologies and the ability to carry out processing steps under extreme conditions (ul-trahigh temperatures, pressures and their gradients), the interest in studying the processes that occur under locally non-equilibrium conditions has grown significantly. The key directions for the description of locally non-equilibrium pro-cesses include thermodynamic, kinetic and phenomenological ones. The locally non-equilibrium transfer equations can also be derived from the Boltzmann equation by using the theory of random walks and molecular-kinetic methods. It should be noted that some options of locally non-equilibrium processes lead to conflicting results. This study aims to develop a method for mathematical modeling of locally nonequilibrium heat conduction processes in solids, which allows determining their temperature with high accuracy during fast and high-intensity heat transfer processes. As applied to heat transfer processes in solids, a generalized heat equation that takes into account the relaxation properties of materials is formulated. The exact analytical solution is obtained using the Fourier method of separation of variables. The methodology for mathematical modeling of locally non-equilibrium transfer processes based on modified conservation laws has been developed. The generalized differential heat equation which allows performing N-fold relaxation of the heat flow and temperature in the modified heat balance equation has been formulated. For the first time, an exact analytical solution to the unsteady heat conduction problem for an infinite plate was obtained taking into account many-fold relaxation. The analysis of the solution to the boundary value problem of locally nonequilibrium heat conduction enabled to conclude that it is impossible to instantly has establish a boundary condition of the first kind. It has been demonstrated that each of the following terms in the relaxed heat equation has an ever smaller effect on the heat transfer process. The obtained results can be used by the scientific and technical personnel of organizations and higher educational institutions in the study of fuel ignition processes, the development of laser processing of materials, the design of highly efficient heat transfer equipment and the description of fast-flowing heat transfer processes.