Prandial Blood Glucose Research Articles

A study on the impact of dietary habits on diabetic and hypertensive status of the patients

Introduction: Type 2 diabetes mellitus and essential hypertension are common non communicable disorders that are frequently present together. Hypertension in the type 2 diabetic individual increases the risk and accelerates the course of cardiac disease, peripheral vascular disease, stroke, retinopathy and nephropathy. The hallmark of hypertension in type 1 and type 2 diabetics appears to be increased peripheral vascular resistance. Objective: 1) To study the importance of diet influences on diabetic and hypertensive patients attending medicine OPD, KR Hospital. Materials and Methods: All the patients attending the medicine OPD of KR hospital, mysuru for 3 months, 210 patients having both hypertension and diabetes were selected cross sectionally, including both males and females of age group 35-50 years. They were categorized as vegetarian and non-vegetarian diet group. All of patients were screened for diabetic and hypertension by checking fasting blood glucose, post prandial blood glucose and blood pressure, Dietary habits and body mass index were also compared. Results: The study found that known cases of type 2 diabetic mellitus and hypertension are very much statistically significant benefits among vegetarian diet compare to non-vegetarian diet. Keywords: Type 2 Diabetes mellitus, Hypertension, Body mass index (BMI) and diet habits.

Correlation between stress level and family support towards fasting and postprandial glucose level in type 2 diabetes mellitus

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by increased blood glucose (hyperglycemia). Stress and family’s support in managing diabetic Mellitus are two critical external factors that influence blood glucose levels. This research aimed to analyze the relationship between stress level and family’s support with fasting blood glucose levels and 2 hours post prandial in T2DM patients.Method: Study design using cross sectional model. Eligible T2DM patients in Tabanan II primary health care center, between period September 2017- February 2018 were evaluated for fasting and post prandial blood glucose and stress level (Depression Anxiety Stres Scale-14) and family support. Spearman correlation test was used to determine correlation between family support and stress level toward fasting and post prandial glucose levels in T2DM patients.Result: The result suggested that 29 respondents (36.3%) get severe stress levels, 51 respondents (63.85%) get high family support, fasting blood glucose level was 168.42±63.57 and post prandial glucose level was 229.18±88.593. There was a positive correlation between family support and stress level toward fasting glucose level (r=0.341; p<0,001) and post prandial glucose level (r=0.276; p<0,001).Conclusion: Stress level and family support in diabetic mellitus management can influence fasting and post prandial glucose level T2DM patients. Managing stress and family support can assist in stabilizing fasting and post prandial glucose level.

Effect of high protein and fat diet on postprandial blood glucose levels in children and adolescents with type 1 diabetes in Cairo, Egypt

Background and aimsTo determine the effect of high protein and high fat meals on post prandial glycemia in patients with type 1 diabetes. MethodsThis study included 51 children and adolescents with type 1 diabetes who were following up at Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), Abo Elrish Children’s hospital, Cairo University.Post prandial blood glucose levels were recorded and compared following three breakfast meals with varying protein and fat content (standard carbohydrate meal, high fat meal, and high protein meal) over a period of 5 hours on 3 consecutive days. ResultsHigh protein meal resulted in hyperglycemia with the peak level at 3.5 hours and continued for 5 hours post prandial while high fat meal caused early hyperglycemia reached the peak at 2 hours then declined towards 5 hours.Comparison of the three different breakfast meals revealed statistically significant difference regarding the postprandial glycemia at 30, 60, 90,120, 180, 210, 240, 270, 300 min. ConclusionMeals high in protein caused sustained increase in postprandial glucose levels over a period of 5 h. However, high fat meals caused early postprandial hyperglycemia. Protein and fat content of meals affect the timing and values of the peak blood glucose as well as the duration of postprandial hyperglycemia. Therefore, fat/protein unit should be taken in consideration while calculating the bolus insulin dose and anticipating the postprandial glucose response.

Relation between iron status and hemoglobin A1c in children with type 1 Diabetes Mellitus

Background: Hemoglobin A1c [HbA1c] is the best standard for measurements of glycemic control level in type 1 diabetes mellitus, especially in children. As iron deficiency anemia is a prevalent finding in children with diabetes, it may affect HbA1c levels in those children. Aim of the work: To determine the effects of iron deficiency anemia on hemoglobin A1c in type 1 diabetes mellitus Patients and methods:This was cross-sectional analytic study was done on 80 children with diabetes with type 1DM receiving insulin therapy; the patients divided into two groups, 21 diabetic children with iron deficiency anemia and 59 diabetic children with iron sufficient state, attending to the pediatric department of Al-Azher University Hospital in Damietta from February 2019 to September 2019. All children included were subjected to complete medical history, general examination, systemic examination, and laboratory investigations; [Complete blood count [CBC], HbA1c, Serum Iron, Serum Ferritin, Total Iron Binding Capacity, Fasting blood glucose, Post Prandial blood glucose, and ESR]. Results:In our study, we divided all patients [80 diabetic children] regarding glycemic control according to HbA1c value into three levels, the first level was optimal glycemic control level [HbA1c 9.0%], there was a statically highly significant increase in HbA1c value of the iron-deficient diabetic group in compared to iron sufficient diabetic group at all levels of glycemic control. Conclusion: Iron deficiency anemia seems to increase HbA1c value in diabetic children Type 1, at the same degree of glycemia.

HbA1c Status in Type II Diabetes Mellitus with and without Iron Deficiency Anemia

Background: Hemoglobin A1C (HbA1c) reflects patient’s glycemic status over the previous 3 months. Previous studies have reported that iron deficiency may elevate HbA1c concentrations, independent of glycemia.
 Aim: To assess the status of HbA1c in clinically diagnosed cases of type II Diabetes mellitus (DM) with and without iron deficiency anemia (IDA).
 Study Design: Case control study in rural hospital of Talegaon Dabhade, Pune.
 Methodology: The study includes 36 clinically diagnosed cases of type II DM with IDA and 36 controls which are age & sex matched having type II DM without IDA. Hematological parameters, fasting and post prandial blood glucose& HbA1c level were assessed in all subjects. Serum ferritin levels were assessed only in cases. Comparison between the parameters of cases and controls was done using appropriate statistical analysis.
 Results: Levels of HbA1c are increased in cases [clinically diagnosed patients of diabetes mellitus with iron deficiency anemia that is IDA] as compared to controls [clinically diagnosed patients of diabetes mellitus without IDA] irrespective of glycemic status.
 Conclusion: This study found a positive correlation between iron deficiency anemia and increased HbA1c levels, Hence IDA is to be taken in consideration while interpreting HbA1c in diagnosis and monitoring of Diabetes mellitus.

Correlation of glycated haemoglobin with fasting and post prandial blood glucose in Type 2 diabetes

Diabetes mellitus is a group of metabolic disorders characterized by high blood sugar levels and this chronic hyperglycemia is responsible for most of the complications of the disease. Glycated haemoglobin or HbA1C is a marker of this hyperglycemia and its complications. The aim of this study is to find out the correlation between HbA1C and FBS, PPBS and hence its effectiveness in assessing the glycemic contol in type 2 diabetic patients.In this cross sectional study, FBS, PPBS and HbA1C values were recorded in the study population which includes 605 type 2 diabetic patients visiting the hospital. FBS and PPBS were estimated using GOD- POD method. HbA1C was analyzed using particle enhanced immunoturbidimetric method and the data analysed and correlated with FBS and PPBS. There was a significant correlation between FBS, PPBS and HbA1C in the study population. It has also been found that PPBS shows a marginally better correlation(0.79) with HbA1C than FBS(0.77). This emphasizes the role of HbA1C as an indicator of blood glucose control, as it correlates well with FBS and PPBS. Maintenance of strict glycemic control retards the development of complications of diabetes, which improves the quality of life of a diabetic patient. This glycemic control can be assessed with reasonable accuracy using HbA1C, as it has been found to correlate well with FBS and PPBS levels, more so with the PPBS levels.

Metformin versus Insulin in Treatment of Gestational Diabetes

Abstract Background: GDM affects both mother and baby during pregnancy and in the long term. Metformin was associated with a lower risk of neonatal hypoglycemia; however, met-formin may slightly increase the risk of prematurity. Aim of Study: The aim of the present study was to compare the safety and efficacy of metformin as an oral anti-diabetic drug with insulin as oral hypoglycemic drugs for management of gestational diabetes mellitus. Patients and Methods: 120 pregnant women with gesta-tional diabetes mellitus were included in this randomized controlled trial. Patients were randomly allocated into 2 groups as follows: Group I: Insulin group (n=64) and Group M: Metformin group (n=56). Follow-up was done every week by measuring fasting and post prandial blood glucose level. Maternal outcomes and neonatal outcomes were recorded. Results: There were statistically significant differences as regard mean fasting and post prandial blood glucose level and mean birth weight in insulin and metformin group. Also, increased CS rate between insulin and metformin group. There were statistically significant differences between insulin group and metformin sub-groups patients as regards birth weight, Apgar score and serum glucose level. Conclusion: We concluded that metformin is an effective and safe treatment option for women with GDM. Metformin is comparable with insulin in glycemic control, providing additional evidence for the use of metformin in GDM.

Clinical Asssessment of Sensorineural Hearing Loss among Diabetes Mellitus Patients

Background: Hearing impairment is known to hamper the quality of life among patients, especially among diabetics due to the association of neuropathy with diabetes. However, the prevalence and degree of the SNHL depends upon different factors, such as age, gender, disease duration of DM, family history and glycemic status of the patients. Therefore, this study aimed to assess the association of SNHL with DM duration and familial DM and gender preponderance among SNHL–DM patients.
 Methods: Total 140 patients with DM were assessed for hearing impairment using Rinne, Weber and Absolute Bone Conduction Tests along with pure tone audiometry. Patients’ glycaemic status was determined by estimating fasting blood glucose (FBG) and post prandial blood glucose (PPBG) levels. Independent t-test, chi-square, ANOVA and Pearson’s correlation tests along with linear regression model were used to find association and correlation using R software.
 Results: Out of 140 patients, 60 were suffering from SNHL and majority were suffering from bilateral minimal hearing loss. SNHL was significantly associated with family history, age, duration of DM, FBG and PPBG levels were(Pvalues:1.79E08, 4.41E-06 and 0.02), however, significant correlated with duration of DM, FBS and PPBG level (r value:0.14–0.41).Furthermore, significant SNHL at 500 and 8000Hz was observed in the present study (Pvalue:0.002).
 Conclusion: A conclusive proof was drawn that family history of DM serve as a valuable variable in assessing the SNHL among DM patients.

Effect of metformin and insulin combination on monocyte chemoattractant protein-1 and cathepsin-D in type 2 diabetes mellitus

Background and aimsMonocyte chemoattractant protein-1 (MCP-1) and cathepsin-D are progressively raised in type 2 diabetes mellitus (T2DM) with both non proliferative and proliferative retinal disease. This study aimed to evaluate the effect of antidiabetic medications on MCP-1 and cathepsin-D. Methods60 patients of T2DM without retinopathy and 60 of diabetic retinopathy were enrolled to receive metformin (500 mg–1000 mg) combined with either glimepiride (1 mg–2 mg) or insulin. The effect of antidiabetic medications on serum MCP-1 and cathepsin-D was assessed. ResultsMean MCP-1 (pg/ml) and cathepsin-D (ng/ml) levels were significantly lower in patients of T2DM with and without retinopathy treated with metformin + insulin (468.52 ± 272.84 vs 234.30 ± 180.58; p < 0.01 and 460.15 ± 128.52 vs 517.33 ± 213.49; p = 0.214) as compared to patients treated with metformin + glimepiride (1434.02 ± 105.27 vs 1256.27 ± 76.76; p < 0.01 and 1689.36 ± 752.57 vs 919.69 ± 675.05; p = < 0.01). No significant correlation of MCP-1 and cathepsin-D with HbA1c, fasting and post prandial blood glucose were found. ConclusionPatients treated with metformin and insulin combination had lower serum MCP-1 and cathepsin-D levels which suggests that this combination may be more effective in reducing the progression of diabetic retinopathy. (CTRI/2018/05/013601).

Comparative bateriological profile with antibiotic resistance pattern among diabetic and non-diabetic patients

Diabetes mellitus is a metabolic disorder which impedes the normal steps of the process of wound healing. It has higher risks of foot infection and postoperative wound infection that is polymicrobial with increased antibiotic resistance. A comparative study of bacteriological profile from the wound samples of diabetic and non- diabetic patients and to understand the relationship between bacterial load and high glycemic index among diabetic patients. A cross sectional study involving 50 diabetic and 50 non- diabetic patients wound swab or pus samples collected under aseptic precautions. Results: Polymicrobial infection is mostly observed. Among the isolates, gram negative bacilli were about 55% and gram positive cocci were about 45%. The most common organism isolated was Staphylococcus aureus in diabetic and non- diabetic wound. In diabetic wound the predominant organism isolated was Staphylococcus aureus and Proteus mirabilis followed by Pseudomonas species. In non- diabetic wound, the predominant organism isolated was Staphylococcus aureus followed by Pseudomonas species. The Total Extended spectrum beta lactamase producer was about 76% whereas total Methicillin Resistant Staphylococcus aureus was 23%. In diabetic wound, glycemic index was poorly controlled in which fasting blood glucose level was &amp;#62; 150mg and post prandial blood glucose level was &amp;#62; 210mg among majority of cases. Antibiotic susceptibility test screening showed gram positive cocci isolates to more sensitive towards Erythromycin, Vancomycin, Amikacin and gram negative bacilli isolates to be more sensitive for Amikacin, Gentamycin and Imipenem. Thus, early diagnosis of diabetic wound infection is required for the antimicrobial therapy.

Effect of High Intensity Interval Training on Blood Glucose Levels in Type 2 Diabetes

Abstract Background: Patients with type 2 diabetes are at signifi-cantly increased risk for cardiovascular morbidity and mortality compared with age-matched healthy control subjects. Aim of Study: Was to determine the effect of high intensity interval training on blood glucose levels in type 2 diabetes. Subject and Methods: Forty diabetic patients of both sexes (12 males and 28 females). They were assigned into two groups equal in number. All patients were diagnosed clinically with established T2DM for more than 7-year duration. Their ages ranged from 45 to 55 years selected from outpatient clinic of Kasr El-Aini, Cairo University, Egypt. Study group with mean age (51.07±3.31) years. and Control group with mean age (51.36± 2.83 ) years. The study group included 20 patients (7 males and 13 females) who practiced high intensity interval training at intensity level of (85-90% of MHR), three times per week for 12 weeks in addition to their optimized oral hypoglycemic medications. Symptom limited exercise test was performed before and after training (12 weeks) to determine maximum heart rate. The control group included 20 patients (5 males 15 females) who only received their optimized oral hypoglycemic medications. Fasting and post prandial blood glucose were measured initially before starting the treatment and after the end of the sessions in both groups. Results: Post-treatment there were a significant improve-ment in both fating and two hours post prandial blood glucose. There were a significant decrease in fasting and two hours post prandial blood glucose. Conclusion: The high intensity interval training is an effective tool to decrease insulin resistance and hyperglycemia this effect is mediated, in part, by the decrease in fasting and two hours post prandial blood glucose in type 2 diabetic patients which consequently helps in the treatment type 2 diabetes.

Effect of treatment with direct antiviral agents (DAAs) on glycemic control in patients with type 2 diabetes mellitus & hepatitis C virus genotype 4

Background and aimsIt is widely recognized that chronic hepatitis C is a metabolic disease that is strongly associated with type 2 diabetes mellitus (T2DM) and insulin resistance (IR). The evidence behind the effect of Direct Anti-Viral Agents (DAAs) therapy on T2DM is conflicting. The aim of the present study was to evaluate the effect of treatment with DAAs on glycemic control in patients with type-2 diabetes mellitus and chronic hepatitis C virus genotype 4. MethodsThis study was a prospective study that conducted on 100 patients with chronic hepatitis C and Type-2 diabetes mellitus, selected from Kafr El-Sheikh Liver Research Center treated with Direct Anti-Viral Agents (DAAs) during the period from September 1, 2017 to last of August 2018. All patients in the study were subjected to the following: Full history taking stressing on the age, gender, previous treatment; clinical examination and laboratory investigations. HBA1C was assessed before and after DAAs treatment. ResultsIn the present study, there was a significant decrease of baseline fasting blood glucose levels after treatment when compared with before treatment. Also, there was a significant decrease of 2 h post prandial blood glucose after treatment when compared with before treatment. There was significant decrease of HBA1c levels after treatment when compared with before treatment. ConclusionsDAAs treatment significantly improved the fasting blood glucose and help better glycemic control. This study augments the importance and the benefits of new Direct Anti-Viral Agents interferon free regimens in diabetic HCV infected patients.

HbA1c –Marker for Long Term Glycemic Control

Background: Protein glycation is a spontaneous reaction that is believed to play a key role in the pathogenesis of many clinical disorders. The glycation of proteins is enhanced by elevated blood glucose concentrations. The major form of protein glycation with a clinical consideration is glycatedhaemoglobin (HbA1c). HbA1c is majorly affected by the blood glucose levels alone. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Studies have suggested that HbA1c levels in type-2 diabetes mellitus patients mostly remains elevated, yet some such patients, with or without tight glycemic control, have HbA1c levels nearly close to or within the normal reference range.Subjects and Methods:In this study HbA1c, fasting blood glucose levels and post prandial blood glucose levels in normal subjects as well as in patients with Type-2 diabetes mellitus excluding the complicated ones were studied.Results:The present study confirms earlier studies that all these levels are tightly correlated and the corresponding p values were &lt; 0.001 which were significant and was estimated by using student t-test.Conclusion: Thus indicating that glycated hemoglobin (HbA1c) can be used to assess the glycemic status of an individual for attaining the treatment goal of preventing long term complications of diabetes mellitus.

Predictors of periodontal disease among rural Indian type 2 diabetic population

BackgroundPeriodontal Disease (PD) is associated with complications of diabetes. Control of the PD reduces glycated hemoglobin (HbA1c) level. This study aimed to evaluate the relationship of PD with duration, severity of diabetes and eGFR. Material and methodA Prospective observational study conducted at Sidhi Vinayaka Hospitals (SVH) Sangareddy during the period of January 2014 to December 2019. Total 1436 patients with a definite diagnosis of type 2 diabetes (T2DM), between the ages of 45–60 years were included. They were classified according to CPITN score for PD and compared against the variables. ResultsA total of 1436 consecutive outpatients attending to SVH were included. Among them 662 (46.1%) were males and 774(53.9%) were females. The mean age of the patients was 48.3(SD ± 10.62) and mean duration of diabetes was 2.9(SD ± 4.18). The mean fasting blood glucose was 198.5(SD ± 85), mean post prandial blood glucose was 277.2 (SD ± 107.7) and mean HBA1c was 9.98% (SD ± 2.6). Among the study group 1198 (83.4%) had none/mild (Grade I) PD, 192(13.4%) had moderate/severe (Grade II) PD and 46(3.2%) were completely edentulous (Grade III). ConclusionThere is a linear correlation between PD and age of patient, duration of diabetes, eGFR and level of glycemic status among rural population with T2DM.

A comparative assessment of safety and tolerability of metoprolol versus carvedilol in patients of chronic stable angina

Background: Angina pectoris is a clinical manifestation characterized by chest pain typically in substerum radiating to left arm, jaw, back lasting for 1-5 minutes and is relieved by rest. Beta blockers are one of the drugs indicated in angina. The aim of the study is to compare safety and tolerability of metoprolol and carvedilol in patients of chronic stable angina.Methods: The study done is randomized, open label, parallel type where tablet carvedilol and tab metoprolol is given in a group of 50 patients each. The patients were followed thereafter on 8th, 16th, 24th week to study safety in terms of haematological parameters like complete blood count, liver function tests, renal function tests, serum sodium, serum potassium, fasting blood glucose, 2 hours post prandial blood glucose, HbA1C, and Lipid profile and tolerability in terms of side effects. The study was conducted for one year and the data was assessed by relevant statistical analysis where p value &lt;0.05 was considered significant.Results: It was seen that the disease was most common in the age group of 51-60 years with male preponderance, and carvedilol was found to cause non-significant decrease in Serum Triglyceride with no change in total cholesterol, HDL-C, LDL-C was found. No significant changes were observed in metoprolol group. There was no significant difference observed when blood sugar profile and other haematological parameters were considered. Both drugs were considered to be equally tolerable.Conclusions: Compared with carvedilol and metoprolol in patients of chronic stable angina, carvedilol resulted in better lipid profile whereas metoprolol showed no changes in lipid parameters.

Efektivitas Penggunaan Oral Antidiabetes Kombinasi Glimepiride Dengan Pioglitazone Pada Pasien Dibetes Mellitus Tipe 2

Diabetes mellitus is a disorder of chronic metabolic syndrome from carbohydrates, lipids and fats resulting from the deficiency of insulin in the body so that it can cause hyperglycemia. Oral Antidiabetic and Insulin is pharmacological therapy that can control blood sugar levels. This study aims to observe the effectiveness of Glimepiride combination therapy with Pioglitazone in type 2 DM patients with fasting blood Glucose and blood Glucose 2 hour post prandial parameters compared to pre and post values. This research method is observational with retrospective data collection and data analyzed descriptively. The sample size was 30 type 2 DM patients who received therapy after 6 months. The results showed that there were significant differences between the value of fasting blood Glucose pre and fasting blood Glucose post and blood Glucose 2 hour post prandial pre and blood Glucose 2 hour post from statistical analysis using paired t-test, with a value of α = 0.00 smaller than α = 0.05. This shows that the combination of Glimepiride with Pioglitazone is effective in blood glucose control in type 2 DM patients.&#x0D; Keywords: Dibetes Mellitus, Oral Antidiabetic, Glimepiride, Piogliatzone

The Relation between Diabetes-Related Distress and Glycemic Control

Abstract Background Diabetes Distress is the understandable sense of burden or defeat that may occasionally punctuate the diabetic patient life. Also, Diabetes distress (DD) refers to the unique, often hidden emotional burdens and worries that are part of the spectrum of patient experience when man-aging a severe demanding chronic disease like diabetes. Objectives is to assess the relationship between Diabetes-related distress (using a Diabetes Distress Screening Scale) and the glycemic control (using A1C) and inflammation (using hs-CRP) in diabetic patients. Patients and Methods This study is a cross sectional study which had been carried out in outpatient clinic of endocrinology department of El Agouza Police Hospital during the period between June 2017 to June 2018.The study was done on 350 Type2 Diabetic patients.BMI,Wist/Hip Ratio, Fasting blood glucose,Post prandial blood glucose,HbA1c,hs-CRP,Creatinin,BUN,SGPT and SGPT were done to the patients, also Diabetes Distress Screening Scale Quastionnaire was completed by the patients. Results In this study we found that there is a highly significant positive relationship between HbA1c and both Fasting Blood Glucose and Post Prandial Blood Glucose. Also,there was a highly significant positive relationship between CRP and Fasting Blood Glucose while there was a non significant relationship between CRP and Post Prandial Blood Glucose.Fasting blood glucose and Post Prandial Blood Glucose showed a highly significant positive relationship with Total DDS score, Emotional burden and Physician realted distress, and showed non significant relationship with Regimen related distress and interpersonal distress.As regard the relation between HbA1c and Total DDS score, there was a highly significant positive relationship between them and also highly significant positive relationship between HbA1c and Emotional burden and physician related distress, but there was non significant relation between HbA1c and Regimen related distress and interpersonal distress. There was highly significant positive relationship between CRP and Total DDS score and also emotional burden, and there was significant positive relationship between CRP and Regimen related distress, and non significant relation between CRP and physician related distress and interpersonal distress. Conclusion In this study 350 type 2 diabetic patients were included. 55 diabetic patients show moderate distress with a highly significant relationship with the glycemic control (HbA1c) and significant relationship with CRP. In this age and sex were non significant factors while duration of diabetes, BMI and Wist-hip ratio show significant relation with HbA1c which reflect the glycemic control.

Prospective Study Comparing the effect of Laparoscopic Mini Gastric Bypass and Laparoscopic Sleeve Gastrectomy on Blood Glucose Level in Type 2 Diabetes Mellitus Obese Patients

Abstract Background Type 2 diabetes mellitus (T2DM) is now a global health priority. The World Health Organization estimates that between 2000 and 2030, the number of diabetic patients will increase by 114%. T2DM and morbid obesity are conditions representing increasing public health threats. They are associated with significant morbidity and mortality, and despite lifestyle modifications and medical support, glycemic control remains difficult to achieve in obese diabetic patients. Objective To compare the effect of laproscopic mini gastric bypass and laproscopic sleeve gastrectomy in controlling type 2 DM obese patients. Patients and Methods Our study was conducted on 40 adult morbid obese patients with T2DM. Twenty patient underwent laparoscopic mini-gastric bypass and the other 20 patient underwent sleeve gastrectomy. All of these patients were followed up preoperative and postoperative at 1, 3, 6, 9 and 12 months by measuring BMI, EWL%, Fasting blood glucose level, 2 hours post prandial blood glucose level, HbA1C also postoperative gastrografin study to exclude complications. Results Our study demonstrated the superiority of MGB over SG in controlling T2DM along 1 year of follow up with lower 1 year HBA1C, FBG, 2HPP blood glucose level in bypass group in comparison with SG group. The results of our study regarding mini gastric bypass MGB patient group showed total remission rate (85%), the other 15% of patients achieved improvement of glycemic control, regarding antidiabetic treatment only 3 out of 20 needed postoperative treatment. The results of our study regarding sleeve gastrectomy patient group showed total remission rate (50%) the other 50% of patients achieved improvement of T2DM control, regarding antidiabetic treatment 9 out of 20 needed postoperative treatment. Conclusion late postoperative complications and long-term maintenance of glycemic control need to be determined by further studies on a larger scale of patients and bigger duration of follow up.

Exploratory Study of Efficacy on Selected Natural Extracts Reducing Post Prandial Blood Glucose Response

Exploratory Study of Efficacy on Selected Natural Extracts Reducing Post Prandial Blood Glucose Response

Dose Response Study of a Natural Extract for Reducing Post Prandial Blood Glucose

Dose Response Study of a Natural Extract for Reducing Post Prandial Blood Glucose