The article examines the state and issues of deregulation, identifies directions for the formation of an organizational and economic mechanism to ensure effective regulatory policy in the agricultural sector of Ukraine. It is based on the principles and strategic directions of regulatory policy in Ukraine in the context of sustainable development, the organizational and legal aspects of making regulatory decisions by legislative and executive authorities in Ukraine, as well as coordination mechanisms involving the State Regulatory Service. The state is responsible for exercising regulatory functions to manage development. On the other hand, excessive control and excessive intervention in all spheres of activity, instead of managed development, lead to a decrease in the efficiency of the entire system's functioning. The experience of Ukraine proves this: according to international comparisons, the country has the highest level of regulation with the lowest GDP per capita in Europe. It is argued that the strategy should include a complex of practical measures of organizational and economic nature, as well as regulatory measures that apply to the entire economy of Ukraine as a whole and to individual enterprises within the agricultural sector, within defined principles. Among the general organizational and economic measures, the implementation of the "regulatory guillotine" method for swift review and maximum abolition of existing administrative constraints is identified. The alignment of subsequent regulatory acts with EU requirements, along with the creation of a corresponding registry accessible to the public, is also considered. It is emphasized that this process should be fully in line with the existing algorithm for the adoption and tracking of regulatory acts, involving all interested parties. Moreover, it is important to work within the existing coordination mechanism to prevent the creation of additional organizational structures in the form of special commissions, services, or committees to avoid manual control.