Plasmon Coupling Effect Research Articles

Plasmonic E-field enhancements and coupling effects of metallic structures using FDTD

The SPP (Surface Plasmon-Polaritons) and BPP (Bulk Plasmon-Polaritons) Electric Field (E-Field) Enhancement patterns and their resonances are the basis for understanding the plasmonic phenomena. We have studied various factors and proposed for the first time the specific optimum structural parameters for best enhancements for materials such as Ag, Au, and Cu in nanoparticle form. These enhancements are illustrated using 3D Finite Difference Time Domain (FDTD) simulations. The plasmonic enhancements in respect of specific sized nanoparticles have been estimated and a study of coupled particle enhancements using a combination of these materials are also reported. In the present work, we have reported factors relating to – i) Size independence for the materials (Ag, Au, and Cu) with the maximum enhancement attained for particles of ~20 nm and varying enhancements factors at their respective peaks of resonant frequency (ωsp) under normal illuminating conditions; ii) Coupling effects for a distance of separation as ~20 nm with size dependence in all the cases, which will highly impact on the Plasmonic Enhancements.

Surface-enhanced Raman spectroscopy integrated with aligner mediated cleavage strategy for ultrasensitive and selective detection of methamphetamine

New drugs and illicit synthesized mixtures detection at crime scenes is a great challenge for detection method, which requires anti-interference and ultrasensitive methods to detect methamphetamine (METH) in seized street samples and biological fluids. Herein, we constructed a surface-enhanced Raman sensing method based on aligner mediated cleavage (AMC) of nucleic acid for quantitative detection of METH for the first time. This method we proposed relied on AMC to achieve programmable sequence-specific cleavage of METH aptamer linked by gold nanoparticles (METH aptamer-Au NPs), the cleavage product-Au NPs conjugates (cleavage aptamer-Au NPs) would hybridize with complementary DNA (cDNA)-Au NPs, resulting in the aggregation of the Au NPs and concomitant plasmonic coupling effect. Besides, due to the base number of METH aptamer-Au NPs was decreased, the interparticle distance of the Au NPs was shortened, which increased the electric field enhancement factor. Thus, under the irradiation of the laser, rhodamine 6G (R6G) adsorbed on Au NPs generated a strong Raman signal. The detection limit reached 7 pM, the linear range was from 10 pM to 10 nM, and this detection method also showed good anti-interference ability and reproducibility in serum.

Core–Shell–Satellite Plasmonic Photocatalyst for Broad-Spectrum Photocatalytic Water Splitting

Photocatalytic water splitting is an ideal way of generating hydrogen, a renewable energy source, from solar energy that would help solve environmental problems. However, current photocatalysts are far from meeting performance requirements for commercial applications. Recently, increasing attention has been paid to surface plasmon resonance (SPR) enhanced photocatalysis using plasmonic nanoparticles (NPs) because of their superior solar energy harvesting capabilities in the visible and near-infrared spectral region. Herein, based on the common CdS photocatalyst, a series of core–shell plasmonic photocatalysts with different core types and shell layer thicknesses were constructed. By combining experimental results and finite element method (FEM), the near-field enhancement mechanism and plasmon-induced resonance energy transfer mechanism was derived. To further improve the energy conversion efficiency, a core–shell–satellite-type plasmonic nanocomposite photocatalyst, Ag@SiO2@CdS-Au, was designed and constructed. Because of hot electron injection and plasmonic coupling effects, the light absorption of the photocatalyst was effectively expanded, which significantly improved the catalytic performance. Compared with traditional CdS, the photocatalytic performance of the plasmonic nanocomposite photocatalyst was improved by more than 200 times. This work deepens the understanding of the mechanisms in SPR enhanced photocatalysis and provides an effective strategy for designing plasmonic photocatalysts.

Influence of nonlocal dielectric response on the Au tip-enhanced fluorescence effect

Tip-enhanced fluorescence (TEF) with ultra-high detection sensitivity and spatial resolution has been a powerful characterization technique in the study of surface science and life science. Herein, a systematically theoretical investigation in the visible range had been performed to study TEF properties of a single molecule located inside a nanogap formed by Au tip and substrate. In the strong localized surface plasmon coupling effect, the contribution of nonlocal dielectric response to the fluorescence quantum yield as well as radiative and energy dissipated decay rates were calculated. It is found that the nonlocal dielectric effects become comparable to the radiative and energy dissipated decay rates with the increasing of the tip-molecule distance, as a result, the nonlocal dielectric effect significantly suppresses the fluorescence process. The huge excitation enhancement at the shorter tip-molecule distance can efficiently compensate the low quantum yield, leading to the great fluorescence enhancement. The results show that the maximum enhancement obtained from the calculations can reach as high as four orders of magnitude by optimizing the tip-molecule distance. These results are not only helpful to our understanding of the TEF mechanism but also valuable for its further applications.

光触发增强葡萄糖氧化酶催化活性的等离子体囊 泡用于程序化光热-饥饿疗法

Glucose oxidase (GOx)-based nanotheranostic agents hold great promise in tumor starvation and its synergistic therapy. Self-assembled plasmonic gold vesicles (GVs) with unique optical properties, large hollow cavity, and strong localized surface plasmon resonance, can be used as multi-functional nanocarriers for synergistic therapy. Herein, GOx-loaded GVs (GV-GOx) were developed for light-triggered GOx release as well as enhanced catalytic activity of GOx, achieving programmable photothermal/starvation therapy. Under near-infrared laser irradiation, the GV-GOx generated strong localized hyperthermia due to plasmon coupling effect of GVs, promoting the release of encapsulated GOx and increasing its catalytic activity, resulting in enhanced tumor starvation effect. In addition, the high photothermal effect improved the cellular uptake of GV-GOx and allowed an efficient monitoring of synergistic tumor treatment via photoacoustic/photothermal duplex imaging in vivo . Impressively, the synergistic photothermal/starvation therapy demonstrated complete tumor eradication in 4T1 tumor-bearing mice, verifying superior synergistic anti-tumor therapeutic effects than monotherapy with no apparent systemic side effects. Our work demonstrated the development of a light-triggered nanoplatform for cancer synergistic therapy.

Color generation through plasmonic coupled dissimilar nano‐metals using mask free deposition

AbstractThe dissimilar nano‐metals were deposited mask free and their plasmonic coupling studied. Coupling between dissimilar nano‐metals can generate a larger red shift in plasmonic resonance when compare to (say) nano‐Ag/Ag coupling of various size. Tunable reflectant color was achieved through plasmonic coupling between nano‐Ag and another nano‐metal. The tunable range is from blue to red; covering the entire optical range. The tunability can be achieved through varying the nano‐metal size and/or through the plasmonic coupling between two dissimilar nano‐metals. The nano‐metals are randomly distributed and packed densely. Hence, the plasmonic coupling effect observed is a collective effect. The distribution of the nano‐particle size, and inter‐particle gap distance were determined. The experimental results show that coupling of nano‐Ag with lighter atom metal such as Mg generates smaller red shift, whereas larger atom metal such as Cr would give larger red shift. The result demonstrates that it is possible to produce reflected color across the optical range using single layer of nano‐metals.

Au-nanoshells modified surface field enhanced LRSPR biosensor with low LOD for highly sensitive hIgG sensing

A high sensitivity side polished fiber long-range surface plasmon resonance (LRSPR) biosensor with electronic field enhanced through surface modified with Au-nanoshells is proposed to detect human immunoglobulin G (hIgG). LRSPR which has high penetration depth and long propagation distance can effectively detect biomacromolecules. The plasmon coupling effect between the Au-nanoshells and Au-film can enhance the electric field intensity on the surface of the sensor, which makes the proposed sensor structure have a lower limit of detection (LOD) and higher sensitivity. The experimental results show that the sensitivity as well as LOD of side-polished-fiber (SPF)/dielectric-matching-layer (DML)/Au-film/Au-nanoshells sensor is 1.84 nm/(µg/mL) and 0.20 µg/mL, which indicates better responses to hIgG with a concentration range of 1–40 µg/ml compared with the SPF/DML/Au-film sensor. The LRSPR sensor modified by Au-nanoshells was used to detect chicken serum samples and the calculated recovery is 107.62%, showing good practicality and superior self-referenced function. The biosensor has the advantages of small volume, high sensitivity and long-distance detection, and has good practicability in the field of biochemical sensing.

Tunable plasmon-assisted electrochemiluminescence strategy for determination of the rapidly accelerated fibrosarcoma B-type (BRAF) gene using concave gold nanocubes.

Atunable plasmon-assisted electrochemiluminescence (ECL) strategy is reportedusing concave Au nanocubes (Au CBs) for rapidly accelerated fibrosarcoma B-type (BRAF) detection. Concave Au CBs exhibit a strong surface plasmon coupling (SPC) effect between its sharp apexes and edges. The high spectral overlap with graphite phase carbon nitride quantum dots (g-C3N4 QDs) is achieved by tuning surface plasmon absorption peak of the concave Au CBs. It maximizes the SPC effect and enhances the ECL signal of g-C3N4 QDs 3-fold. The SPC effect of Au CBs is twice as high as with Au NPs. We also employed a toehold-mediated strand displacement (TMSD) strategy for sensitive target recycling amplification. Under optimal conditions, this sensor can determine BRAF gene from 1pM to 1nM with a detection limit of 3.06 × 10-5nM (S/N = 3) and RSD 3.67%. With the aid of the TMSD strategy and tunable plasmon-assisted ECL sensing mode, this sensor also exhibits goodanalytical performance in human serum with satisfactory recovery of 90.2~109%. The proposed strategyprovides a promising method to effectively enhance spectral overlap and detect BRAF gene.

An intelligent platform based on acidity-triggered aggregation of gold nanoparticles for precise photothermal ablation of focal bacterial infection

Precisely striking the bacterially infected site and avoiding damage to healthy tissues is vital for bacterial infection therapy. Herein, an intelligent antibacterial platform that triggers the aggregation of gold nanoparticles (AuNPs) on bacterial surface based on the acidic environment of bacterial infection was developed. Also, the AuNPs functionalized with an acidity-triggered moiety (Pep-DA) exhibited a charge-convertible properties to target bacterial infection sites. The positively charged acidity-triggered AuNPs endowed the AuNPs aggregate on negatively charged bacterial surface in the infected site rather than in healthy tissues, achieving the threshold to interparticle plasmonic coupling effect among AuNPs, and killing bacteria accurately under NIR irradiation light. This acidity-triggered aggregation strategy provides an excellent therapeutic mode for treating focal bacterial infections with no critical damage to healthy tissues.

Plasmonic coupling enhancement of core-shell Au@Pt assemblies on ZnIn2S4 nanosheets towards photocatalytic H2 production

Hydrogen production via photocatalytic water splitting would be a promising technique for the utilization of hydrogen energy and solar energy. Surface plasmon resonance (SPR) of noble metal nanoparticles (NPs), such as Au, offers a fascinating arena to develop efficient photocatalysts with superior visible light harvesting properties and excellent catalytic activities. However, the photocatalytic performance enhancement based on SPR effect is limited by the relatively small contribution of the isolated plasmonic NPs. In the present work, the Au@Pt/ZnIn2S4 (ZIS) photocatalyst can be successfully constructed by the assemblies of core-shell Au@Pt NPs, consisted of plasmonic Au NP surrounded by catalytic Pt NPs, on three-dimensional (3D) ZIS microsphere in consideration of collective excitation of plasmonic NPs assemblies, demonstrating extraordinary catalytic performance of hydrogen production under visible light (≥420 nm) during water splitting process. The H2 production amount and rate over Au16@Pt/ZIS can reach 41747 μmol g−1 and 4174.7 μmol g−1h−1 under visible light, about 10 times higher than those of ZIS, respectively. The apparent quantum yield (AQY) of Au16@Pt/ZIS dramatically rises to 6.23%, nearly 10 times than that of ZIS (0.62%). Hence, the assembly formation of core-shell NPs and the introduction of ZIS can significantly enhance the photocatalytic performance of plasmonic metal NPs. The experimental results and FDTD simulation confirm that the plasmonic coupling effect of Au@Pt assemblies can generate much intensive electromagnetic (EM) field on ZIS surface, which further extends the light harvesting to visible-to-near infrared region and simultaneously boosts the generation rate of plasmon-induced hot electrons from Au and photoexcited electrons from ZIS. In addition, the Pt shell plays the role of electron sink, leading to the efficiently separation of electron-holes in Au NPs and ZIS and thus further increase the H2 evolution. All of these make Au@Pt/ZIS possess the extraordinary H2 evolution ability. We believe that the present strategy would be a significant contribution to design and prepare the efficient photocatalysts based on the plasmonic effect towards water splitting.

Biochemical reprogramming of tumors for active modulation of receptor-mediated nanomaterial delivery

Here we report that reactive oxygen species (ROS) can reprogram cancer cells to increase the expression of specific receptors and modulate the delivery of nanomaterials. Gold and γ-polyglutamic acid (γ-PGA) hybrid nanoparticles (PGANP) were prepared via a facile single-step process. Gold nanoclusters in PGANP were dispersed within the tangled γ-PGA matrix of the nanoparticles. The condensed assembly of gold nanoclusters in γ-PGA matrix enabled the interparticle plasmon coupling effect, which lacks in single gold nanoparticles. Compared with gold nanoparticles of the similar sizes, PGANP showed significantly higher absorbance at near infrared (NIR) wavelength and light-to-heat converting ratios, resulting in greater temperature increase upon NIR light irradiation. Pretreatment of HeLa cancer cells with methylene blue (MB) generated reactive oxygen species. The ROS reprogrammed the cancer cells to express higher cell membrane levels of gamma glutamyl transferase (GGT), which is known to bind to γ-PGA of PGANP. MB pretreatment significantly enhanced delivery of PGANP to cancer cells. Cancer cells internalized PGANP to a greater extent and, were highly susceptible to irradiation with NIR light, which reduced cell viability to near zero. In vivo, MB pretreatment of HeLa xenograft mice increased the expression of GGT in tumor tissues. In mice pretreated with MB and exposed to NIR irradiation, PGANP treatment resulted in complete tumor ablation. The strategy of actively reprogramming tumor membrane levels of target receptors could be widely applied to overcome the heterogeneity of cancer cells. Although we used interparticle plasmon coupling effect-based PGANP for proving the concept of receptor-modulated delivery, this strategy could be broadly applicable to the active modulation of the receptor-mediated delivery of anticancer nanomaterials.

Cubic-shape hematite decorated with plasmonic Ag-Au bimetals for enhanced photocatalysis under visible light irradiation

Cubic-shape hematite (C-Fe2O3) was facilely prepared by hydrothermal autoclave reaction of Fe3+ in the presence of 1,12-diaminododecane at 130 °C for 10 h. The surface of C-Fe2O3 was decorated with nanosilvers through the sonochemical reduction of Ag precursor (0.1–0.4 ml of 1.0 wt.% AgNO3), so-called C-Fe2O3@Ag. After then, the C-Fe2O3@Ag was plated with Au layer via galvanic-assisted reduction of Au precursor (0.04–0.14 ml of 1.0 wt.% HAuCl4), so-called C-Fe2O3@Ag-Au. Scanning electron microscopy demonstrated the formation of cubic-shape hematite deposited with plasmonic nanometals. X-ray photoelectron spectroscopy analysis confirmed the existence of Ag and Au crystals. Photocatalytic performance of the hematite samples was estimated towards the degradation of methylene blue (MB) under visible light. The C-Fe2O3@Ag (0.2 ml) exhibited the five-fold increase of photocatalytic activity to that of the pristine C-Fe2O3. Furthermore, Au-deposited C-Fe2O3@Ag (0.2 ml), i.e., C-Fe2O3@Ag-Au, exhibited the 200% increase of photocatalytic activity to that of the C-Fe2O3@Ag (0.2 ml), owing to the plasmonic coupling effect on the extended visible light absorbance and enhanced separation efficiency of electron-hole pairs on the hematite surface.

Magnetic-plasmonic yolk-shell nanostructure-based plasmon-enhanced electrochemiluminescence sensor

In this work, plasmon-enhanced electrochemiluminescence (ECL) nanosensor based on magnetic-plasmonic Fe3O4 yolk/Au shell (M@Au) is designed for Kirsten rat sarcoma (K-RAS) gene detection. K-RAS is a mouse sarcoma virus oncogene, which mutation occurs in the initial phase of malignant tumor transformation. Thus, the detection of KAS is meaningful for the diagnosis of early cancer. Graphite phase carbon nitride quantum dots (g-C3N4 QDs) have low toxicity, and stable chemical properties. However, the low ECL intensity of g-C3N4 QDs limits its sensing application. Herein, a sandwich-typed sensor with a combination of M@Au and g-C3N4 QDs is constructed. In yolk-shell M@Au, the internal Fe3O4 nanoparticle (NP) has good magnetic property. The outer Au shell has better surface plasmon coupling (SPC) effect than conventional Au NPs. Furthermore, the middle cavity in the yolk-shell nanostructure solves the problem of electron transfer between Fe3O4 NP and Au shell. Therefore, the yolk-shell M@Au shows strong surface SPC effect, which amplifies the ECL signal of g-C3N4 QDs 2.8-fold. Based on the plasmon-enhanced ECL mode, this sensor performs well with a wide range (1 fM−1 nM) for nucleic acid detection. It also shows the high stability and selectivity of the sensing system in human serum test.

Plasmonic Coupling of One-Dimensional Palladium Nanoparticle Chains

In this paper, we investigate the plasmonic coupling effects on the localized surface plasmon resonances (LSPRs) of palladium nanoparticle chains. We show the transmission electron microscopy (TEM) images and the extinction cross-section spectra of near-contact palladium nanoparticle chains from monomer to pentamer. The extinction spectra of chains nanoparticles were measured by far-field polarization spectroscopy over a large spectral range (ultraviolet, visible and near-infrared) and compared with numerical calculations based on finite element method (FEM). For single palladium nanoparticle, the LSPR phenomenon appears in ultraviolet region. By addition of palladium nanoparticles to the chain, we observe a tunable red-shifting on the spectral position due to plasmonic coupling between palladium nanoparticles and a systematic spectral amplitude enhancement with the appearance of new modes of resonance.

Oxide Coated Nano-Porous Ag Thin Film for Chemical Sensing By Gas Flow Sputtering

A completely non-destructive analytical method is one of the great advantages of Raman spectroscopy. However, low efficiency of Raman signals should be improved to be widely used for detecting less than ppm of chemicals. Surface enhanced Raman scattering (SERS), which is a valuable technique for detecting the target substance very sensitively, is a method of amplifying Raman signals by the plasmon coupling effect at the gap between the nanoparticles. For this reason, materials and the nano-structure such as particle size, shape, gap and density were major factors for determining the performance of the SERS substrate.In this study, gas flow sputtering (GFS) was used for fabricating SERS substrates. The nano-porous structure was observed using scanning electron microscope (SEM) and crystal structures were also analyzed by X-ray diffraction (XRD). The density of the nano-porous structure was calculated using the thickness of the film and the mass difference before and after deposition.Silver (Ag) was widely studied as SERS substrate, due to excellent SERS effect and lower price than that of other noble metals. However, Ag has a significant degradation in SERS effect with time which appears to be a problem caused by oxidation of the Ag surface. Owing to this problem, fabricating a highly reproducible SERS substrate is a challenging issue and many researchers are conducting study.To solve this problem, Ag dense film and oxide film were sequentially deposited. Then, Ag nano-porous thin film was deposited on the oxide film to form a dielectric nano-gap between Ag dense film and Ag nano-porous thin film. Also, to protect from oxidation, Ag nano-porous thin film was coated with a thin oxide film using in-situ co-sputtering. The structure of nano-porous thin film was controlled by varying the sputtering power, time, process pressure.As a result, rhodamine 6G of less than 0.5 uM was successfully detected and it showed much improved Raman signal compared with single Ag nano-porous thin film. In addition, the aging problem, which was the most important issue, also reduced noticeably.

Convenient Construction of Orthogonal Dual Aptamer-Based Plasmonic Immunosandwich Assay for Probing Protein Disease Markers in Complex Samples and Living Animals.

Aptamers, because of their outstanding merits including simple synthesis and easy modification, have been widely used as antibody alternatives to construct novel immunosandwich assays. Dual aptamer-based sandwich assays exhibit multiple advantages over conventional immunosandwich assays and single aptamer-based sandwich assays. However, their construction is hampered by the limited knowledge of binding orthogonality of aptamers reported in the literature. Herein, we present a new strategy for conveniently constructing an orthogonal dual aptamer-based plasmonic immunosandwich assay (odA-PISA) for probing proteins in complex samples and living animals. An orthogonal aptamer pair was first efficiently selected from the aptamers reported in the literature by affinity capillary electrophoresis. Then, a target protein-capturing gold thin-layer-coated probe and silver nanoparticle-based Raman labeling nanotags were conveniently prepared with the selected aptamers and used to construct the assay. The double aptamers used ensured the specificity, whereas the plasmonic coupling effect between the target-capturing probe and the generated Raman nanotags significantly enhanced the Raman signal intensity, providing high sensitivity. As a proof of principle, alkaline phosphatase (ALP) was used as the target. The constructed odA-PISA exhibited high specificity and high sensitivity toward ALP, giving cross-reactivity ≤ 4.2% and the limit of detection of 3.8 pM (S/N = 4). The quantitative determination of ALP in human serum and probing ALP in tumor-bearing mice were achieved, showing the great application potential of the method. This strategy is widely applicable to other protein disease markers. Therefore, it opened a new access to the construction of sensitive dual aptamer-based sandwich assays for real-world applications, particularly disease diagnosis.

Nanoparticle enhanced laser ablation and consequent effects on laser induced plasma optical emission

In this paper the plasmon enhanced ablation for elemental analysis is investigated with several experiments in order to point out the crucial questions concerning the laser matter interaction under the effect of plasmonic coupling between the nanoparticle (NP) system and the laser ablation pulse. The correlation between the electromagnetic field enhancement and the signal enhancement during NP enhanced laser induced breakdown spectroscopy (NELIBS), as well as the laser matter interaction at the nanoscale, is discussed in the case of noble metal NPs deposited on metal samples. The results suggest that, while laser pulse energy is concentrated in the space between the NPs, the NP system is shielded by the field enhancement distribution after the laser pulse interacts with the plasmons of the NP system. Finally the comparison of the laser energy transfer to the sample between NELIBS and conventional LIBS is discussed.

Control of quantum dot emission by colloidal plasmonic pyramids in a liquid crystal.

We study the plasmon-enhanced fluorescence of a single semiconducting quantum dot near the apex of a colloidal gold pyramid spatially localized by the elastic forces of the liquid crystal host. The gold pyramid particles were manipulated within the liquid crystal medium by laser tweezers, enabling the self-assembly of a semiconducting quantum dot dispersed in the medium near the apex of the gold pyramid, allowing us to probe the plasmon-exciton interactions. We demonstrate the effect of plasmon coupling on the fluorescence lifetime and the blinking properties of the quantum dot. Our results demonstrate that topological defects around colloidal particles in liquid crystal combined with laser tweezers provide a platform for plasmon exciton interaction studies and potentially could be extended to the scale of composite materials for nanophotonic applications.

Self-assembling two-dimensional nanophotonic arrays for reflectivity-based sensing.

We propose a nanoplasmonic platform that can be used for sensing trace levels of heavy metals in solutions via simple optical reflectivity measurements. The considered example is a lead sensor, which relies on the lead-mediated assembly of glutathione-functionalized gold nanoparticles (NPs) at a self-healing water/DCE liquid | liquid interface (LLI). Capillary forces tend to trap each NP at the LLI while the negatively charged ligands prevent the NPs settling too close to each other. In the presence of lead, due to chelation between the lead ion and glutathione ligand, the NPs assemble into a dense quasi-2D interfacial array. Such a dense assembly of plasmonic NPs can generate a remarkable broad-band reflectance signal, which is absent when NPs are adsorbed at the interface far apart from each other. The condensing effect of the LLI and the plasmonic coupling effect among the NP array gives rise to a dramatic enhancement of the reflectivity signals. Importantly, we show that our theory of the optical reflectivity from such an array of NPs works in perfect harmony with the physics and chemistry of the system with the key parameter being the interparticle distance at the interface. As a lead sensor, the system is fast, stable, and can achieve detection limits down to 14 ppb. Future alternative recognizing ligands can be used to build sister platforms for detecting other heavy metals.

Synergistic plasmon resonance coupling and light capture in ordered nanoarrays as ultrasensitive and reproducible SERS substrates.

An effective SERS substrate for on-field detection needs to satisfy high sensitivity to analyte and signal reproducibility even in the special case of tilting or bending of substrates. Herein, we transferred monolayer AuNPs into a nanocavity to construct a Au particle-in-hemispherical honeycomb nanoarray (PIHHN) as an ultrasensitive and spatially reproducible SERS substrate. The capacity of detection for R6G in an optimal PIHHN substrate is as low as a concentration of 10-15 M, and the RSD of signal deviation is no more than 5.6%. FDTD simulations explain that placing AuNPs into a metallic nanocavity can capture and focus the light field to improve the interaction between the light and the substrate and provide the collective effect of multiple plasmon coupling, which can induce a stronger electromagnetic field. In addition, the system can generate more hot spots between AuNPs and between AuNPs and the metallic nanocavity. In particular, when the substrate is tilted or bent at an angle from 0° to 60°, the SERS performance remains stable due to the rotational symmetry of the PIHHN structure, which demonstrates the capability of on-field detection. Furthermore, the PIHHN substrate is employed as a highly sensitive multiplex sensor in on-field analysis for contaminated soil, achieving the detection of analytes down to 0.5 ppb.