The fatigue resistance of the hot corrosion pitted ME3 disk superalloy was investigated. Low cycle fatigue specimens were subjected to hot corrosion exposures that produced pits on the gage sections. These specimens were tested at varied temperatures and strain ranges. Corrosion pitting influenced fatigue life and failure mode by varying degrees, depending on temperature and strain range. As observed through interrupted tests, fatigue cracks initiated at a smaller fraction of life for high-temperature tests, in comparison to that at low temperatures. Correspondingly, the crack initiation failure mode changed significantly with test temperature. While cracks initiated from the hot corrosion pits for all test conditions, at 704 °C the intergranular initiation failure mode was dominant, whereas at the lower temperatures cracks initiated within the pits from crystallographic facets. Finite element analyses were performed to quantify the effect of varying pit dimensions and spacing on elastic stress concentration. The highest stress concentration was calculated to occur at the narrow ligaments between overlapping hot corrosion pits. Increasing the number of overlapping pits did not further add to the stress concentration. There was good qualitative agreement between the calculated stress concentrations and the location of crack initiations for tests conducted at 704 °C but not for tests conducted at 204 °C.