Original Concept Research Articles

The human factor and technical conditions in the process of shaping the safety of medical staff during the treatment of cancer diseases – an original concept of drug packaging using CAD software and 3D bioprinting

Purpose: The use of 3D printers for printing tablets, CAD software for 3D modeling for medical purposes, as well as the impact of the human factor on the safety of medical staff during the care of a cancer patient were studied.
 Method: concept based on statistical data from the National Cancer Registry and information on bioprinters and 3D printers. Concept using AutoCAD software as well as statistical data related to accidents at work of medical personnel.
 Findings: The concept of packaging anticancer drugs for an individual patient with the use of AutoCAD software as well as bioprints and 3D printers and its impact on the safety of medical staff.
 Value: Thanks to 3D bioprinting and packaging of anticancer drugs, it will be possible to conduct further research on the treatment of cancer patients around the world with drug packages, to develop new technologies for the production of anticancer drugs, to increase access to drugs. The concept may force the standardization of treatment of oncological patients, as well as changes in the procedures for drug approval. The presented concept is the basis for further research. The concept will also affect the protection of medical personnel against human errors as well as the improvement of occupational health and safety.
 Paper type: practical.

Lecture Course “Modern Physics”

In the paper, the structure of the lecture course “Modern Physics” is described in detail. The course is based on a logical presentation of modern ideas about quantum-, atomic-, nuclear-, and molecular physics as well as astrophysics. A special attention is paid to a relatively new interdisciplinary research field, namely the physics of open systems, and to the study of clusters as one of the most promising scientific areas. Separate chapters of the textbook are devoted to nonlinear optics, quantum information, structure and dynamics of molecules. The fundamental laws and concepts of modern physics, their relationship and origin are comprehensively discussed. It is underlined that this lecture course is intended, first of all, for students of technical universities, postgraduate students of relevant specialties, as well as professors of vocation-related subjects. The inclusion of new sections of physics in the curricula of universities is rationalized, in particular, by the fact that physics is closely related to engineering. Due to this fact, the important role that physics plays in society becomes especially evident. The paper may also be of interest to those who are fond of physics and its state-of-the art.

On the use of sentiment analysis for linguistics research. Observations on sentiment polarity and the use of the progressive in Italian.

This article offers a conceptual and methodological contribution to linguistics by exploring the potential value of using sentiment analysis (SA) for research in this field. Firstly, it discusses the limitations and advantages of using SA for linguistics research including the wider epistemological implications of its application outside of its original conception as a product reviews analysis tool. Methodologically, it tests its applicability against an established linguistic case: the correlation between subjective attitudes such as surprise, irritation and discontent and the use of the progressive. The language example is Italian for which this function of the progressive form has not been analyzed yet. The analysis applies FEEL-IT, a state-of-the-art transformer-based machine learning model for emotion and sentiment classification in Italian on language samples from various sources as collected in Evalita-2014 (238,556 words). The results show statistically significant correlations between negative subjective attitudes and the use of the progressive in line with previous accounts in other languages. The article concludes with a few additional propositions for practitioners and researchers using SA.

POTENCIAL DE OBTENÇÃO DA CERTIFICAÇÃO LEED BD+C VERSÃO 4.1 EM EDIFÍCIO ESCOLAR PÚBLICO

Civil construction generates significant impacts on the environment and society. In order to overcome these effects, the LEED environmental certification is recognized as the one with the highest number of “green buildings” accredited in Brazil. This work presents the environmental impact caused by a public-s-chool building, still in the design phase, according to the LEED BD+C (Building and Design Construction): Schools v4.1. Afterwards, feasible interventions were proposed to the project aiming for the building to reach the Certified level, with the least impact on the original concept. Therefore, this study presents a practical contribution by serving as a guide for the continuity of the project’s development, in addition to serving as a basis for similar studies.

Trapping metastatic cancer cells with mechanical ratchet arrays

Current treatments for cancer, such as chemotherapy, radiotherapy, immunotherapy, and surgery, have positive results but are generally ineffective against metastatic tumors. Treatment effectiveness can be improved by employing bioengineered cancer traps, typically utilizing chemoattractant-loaded materials, to attract infiltrating cancer cells preventing their uncontrolled spread and potentially enabling eradication. However, the encapsulated chemical compounds can have adverse effects on other cells causing unwanted responses, and the generated gradients can evolve unpredictably. Here, we report the development of a cancer trap based on mechanical ratchet structures to capture metastatic cells. The traps use an array of asymmetric local features to mechanically attract cancer cells and direct their migration for prolonged periods. The trapping efficiency was found to be greater than isotropic or inverse anisotropic ratchet structures on either disseminating cancer cells and tumor spheroids. Importantly, the traps exhibited a reduced effectiveness when targeting non-metastatic and non-tumorigenic cells, underscoring their particular suitability for capturing highly invasive cancer cells. Overall, this original approach may have therapeutic implications for fighting cancer, and may also be used to control cell motility for other biological processes. Statement of significanceCurrent cancer treatments have limitations in treating metastatic tumors, where cancer cells can invade distant organs. Biomaterials loaded with chemoattractants can be implanted to attract and capture metastatic cells preventing uncontrolled spread. However, encapsulated chemical compounds can have adverse effects on other cells, and gradients can evolve unpredictably. This paper presents an original concept of “cancer traps” based on using mechanical ratchet-based structures to capture metastatic cancer cells, with greater trapping efficiency and stability than previously studied methods. This innovative approach has significant potential clinical implications for fighting cancer, particularly in treating metastatic tumors. Additionally, it could be applied to control cell motility for other biological processes, opening new possibilities for biomedicine and tissue engineering.

Inertial Propulsion of a Mobile Platform Driven by Two Eccentric Bodies

In recent decades, enthusiasts and researchers from all over the world have invested a lot of energy and time in trying to develop linear propulsion systems using the inertial force generated by two masses revolving in opposite directions. The authors present an original concept for the propulsion system of a mobile platform by using the inertial force generated by two eccentric bodies that are revolving in opposite directions. Based on this approach, a wheeled vehicle was designed, built using additive manufacturing techniques, and finally tested. Validation of the concept and verification of the analytically derived kinematic parameters were carried out by 3D modeling and motion simulation performed in SolidWorks 2023. It was concluded that the initial position of the eccentric bodies determines the direction of movement. Moreover, a favorable correlation of the eccentric bodies’ masses with the entire platform mass is able to ensure the movement at an oscillating but permanently positive speed.

SHAPE DEPENDENT MOTION INTERPOLANTS FOR PLANAR OBJECTS.

Kinematics is most commonly about the motion of unbounded spaces. This paper deals with the kinematics of bounded shapes in a plane. This paper studies the problem of motion interpolation of a planar object with its shape taken into consideration. It applies and extends a shape dependent distance measure between two positions in the context of motion interpolation. Instead of using a fixed reference frame, a shape-dependent inertia frame of reference is used for formulating the distance between positions of a rigid object in a plane. The resulting distance function is then decomposed in two orthogonal directions and is used to formulate an interpolating function for the distance functions in these two directions. This leads to a shape dependent interpolation of translational components of a planar motion. In difference to the original concept of Kazerounian and Rastegar that comes with a shape dependent measure of the angular motion, it is assumed in this paper that the angular motion is shape independent as the angular metric is dimensionless. The resulting distance measure is not only a combination of translation and rotation parameters but also depends on the area moments of inertia of the object. It derives the explicit expressions for decomposing the shape dependent distance in two orthogonal directions, which is then used to obtain shape dependent motion interpolants in these directions. The resulting interpolants have similarities to the well-known spherical linear interpolants widely used in computer graphics in that they are defined using sinusoidal functions instead of linear interpolation in Euclidean space. The path of the interpolating motion can be adjusted by different choice of shape parameters. Examples are provided to illustrate the effect of object shapes on the resulting interpolating motions.

Human Fossils from the First Quarter of the 21st Century

Significant discoveries have been made from the first quarter of this Century in the field of evolutionary biology to redefine the human evolution. Discoveries present the morphological variability in fossil forms and indicate the valuable role of that particular continent in tracing the human origin. This article presents a general review of the human fossils found so far of this century that force us to rethink about the current concept of human origin. Most of the fossils have been found in East Africa, South Africa, Central Africa, Russia, Israel and Indonesia. Some of these are related to Australopithecus afarensis, some to Aus. africanus while some to Neanderthal. A complete human skeleton remains has been found from Ethiopia (Middle Awash region) and named as Ardipithecus ramidus is believed to be the common ancestor of humans and chimpanzees. Naser Ramla from Israelis considered as an ancestor of Neanderthals because it used stone tool production technology to make tools. Some fossils share features of both Australopithecus and early Homo, such as Orrorin tugenesis and Homo naledi. Australopithecus deyremeda is considered as an extinct species of Australopithecine. Some of these are contemporary of modern humans, such as Homo florensis, whose complete skeleton has been found from the Flores island of Indonesia and it has also been considered as an Asian descendant of Homoerectus. Denisovans found in Russia's Denisova cave is considered as a new species, it belongs to the Lower Middle Palaeolithic period, so it is also considered to be related to Neanderthal, although its fossil remains include only digit bone, 4 tooth, parts of jaw and long bones and parietal part of the cranium.

Geological, Mineralogical, and Geochemical Features of the Ugakhan Gold Ore Deposit of the Sukhoi Log Type (Baikal–Patom Belt)

Abstract —The Ugakhan gold ore deposit is located within the Lena gold ore province, the largest one in Russia. It belongs to the group of deposits of the Sukhoi Log genetic type. We present results of petrological, mineralogical, and isotope-geochemical study of gold mineralization at the deposit. A scheme of the sequence of mineral formation at the deposit has been developed, which includes five stages: (1) the early (syndiagenetic) stage, when framboid pyrite I enriched in Au, Ni, Co, and As formed; 2) the stage of catagenesis of ore-bearing sediments, with recrystallization of early pyrite I and crystallization of pyrite II, also with elevated Au, Ni, Co, and As contents; (3) the stage of progressive metamorphism, with the formation of ore pyrrhotite from a water–CO2 fluid with a high content of H2S; (4) the ore formation stage, marked by an assemblage of pyrite III, galena, sphalerite, chalcopyrite, and native gold at the deposit, which was synchronous with regressive metamorphism in the region; (5) crystallization of post-ore euhedral coarse-grained pyrite IV. The geochemical and isotope (δ34S and Pb–Pb) data rule out the input of mineral-forming components from an additional (external) source during the hydrothermal-metasomatic transformation of ore-bearing rocks. The δ34S values in the early morphotypes of pyrite in the deposit ores vary from +5.7 to +9.1‰ and are close to the δ34S values of the barren rocks of the Buzhuikhta Formation (+4.2 to +16.4‰). The Pb–Pb isotope characteristics and regularities of variations in Pb isotope composition established for gold mineralization indicate a predominant inflow of lead from Neoproterozoic metasedimentary strata. The mineral and geochemical specifics of the Ugakhan deposit are consistent with the concept of the metamorphic origin of gold deposits of the Sukhoi Log type, which confirms that the rocks of the Buzhuikhta Formation are promising for new gold ore objects.

Using Non-Standard Methods of Promotion in the Event Industry in Conditions of Limited Resources

Globalization challenges companies, demanding from them an immediate response to changes in society and the use of non-standard methods of promotion that can attract the target public. Special events are an effective brand promotion tool, but not without difficulties. Even in conditions of a limited budget, provided high-quality management, an original concept and prompt response to current socio-economic and political changes, special events can bring profit, increase the efficiency of the organization, highlight the brand in the market, thereby increasing the competitiveness of the company. Each event requires the development of a concept as a separate opportunity to best influence the target group. The purpose of the work is to identify non-standard ways to promote special events in conditions of limited resources and to determine their effectiveness. To achieve the result, the author applied methods of systematization and generalization of existing experience on the subject of research, as well as methods of theoretical and empirical analysis, thanks to which recommendations were developed on the use of non-standard methods of promotion within the framework of solving problems for the implementation of a special event in modern conditions.

Sacred Music in a Sacred Space: Performance as Communal Event


 
 
 During the Easter Week of 1999, the composer John Tavener (1944-2013) visited the Holy Trinity Archdiocesan Greek Orthodox Cathedral in New York City, to attend a unique concert, that occured under the auspicies of His Eminence Archbishop Spyridon, featuring Tavener's sacred para- liturgical music, conducted by the late maestro Dino Anagnost (1944-2011). Using this event as a base, regarding its reception and meaning, this paper ventures to compose a theoretical context, in which the performance of sacred works can function in a sacred performance space, while focusing on the composer's understanding of the notion of sacred in composition and in music making in general. Througout the course this research paper, the reader will explore ways in which the systematic application of musicological and theological tools on the complete musical material of the performed works, leads to a provocative analogy of sacred music being performed in a sacred space with a communal event within the church community. Ultimately, this paper suggests that such an occassion is closer to the idea of ecclesial event; an original concept created by the greek philosopher and theologian Christos Yannaras (1936-).
 
 

Aitchison’s Compositional Data Analysis 40 Years on: A Reappraisal

The development of John Aitchison’s approach to compositional data analysis is followed since his paper read to the Royal Statistical Society in 1982. Aitchison’s logratio approach, which was proposed to solve the problematic aspects of working with data with a fixed-sum constraint, is summarized and reappraised. It is maintained that the properties on which this approach was originally built, the main one being subcompositional coherence, are not required to be satisfied exactly—quasi-coherence is sufficient, that is near enough to being coherent for all practical purposes. This opens up the field to using simpler data transformations, such as power transformations, that permit zero values in the data. The additional property of exact isometry, which was subsequently introduced and not in Aitchison’s original conception, imposed the use of isometric logratio transformations, but these are complicated and problematic to interpret, involving ratios of geometric means. If this property is regarded as important in certain analytical contexts, for example, unsupervised learning, it can be relaxed by showing that regular pairwise logratios, as well as the alternative quasi-coherent transformations, can also be quasi-isometric, meaning they are close enough to exact isometry for all practical purposes. It is concluded that the isometric and related logratio transformations such as pivot logratios are not a prerequisite for good practice, although many authors insist on their obligatory use. This conclusion is fully supported here by case studies in geochemistry and in genomics, where the good performance is demonstrated of pairwise logratios, as originally proposed by Aitchison, or Box–Cox power transforms of the original compositions where no zero replacements are necessary.

Granular fuzzy sets and three-way approximations of fuzzy sets

A Pawlak approximation space is a pair of a ground set/space and a quotient set/space, where the latter is induced by an equivalence relation on the former. With this two-space understanding, it is possible to lift any concepts and notions from the ground space to the quotient space. The results are granular versions that approximate the original concepts and notions. In this paper, we investigate the problem of lifting a fuzzy set in the ground space to granular fuzzy sets in the quotient space. By applying the principles of three-way decision, we introduce the idea of three-way granular approximations of fuzzy sets in terms of three granular fuzzy sets that represent the two extremes and one middle. The two extremes are given by granular rough fuzzy sets. We present several different ways to interpret and construct a middle.

Thermodynamic performance evaluation and power/cooling energy trade-off estimation of an isolated system driven by nuclear energy

The wide temperature range requirement of components in an isolated system offers the possibility for power regulation for combined cooling and power system by adjusting the cooling energy supplement amount. To achieve the flexible operation and combined energy output for the independent nuclear power system, this paper proposes an isolated combined cooling and power system driven by nuclear energy to track power load by making an energy trade-off between net power output and cooling capacity by combing the steam Rankine cycle with the ammonia-water mixture cycle. Parametric analysis and single objective optimization are carried out to explore the effect of the key parameters on system performance. Multi-objective optimization is presented to obtain the optimal parameters group. The regulation capacity of power and cooling is analyzed by trade-off strategy for the proposed system based on the design condition. Results show that the optimal thermal efficiency of the proposed system is 31.60 % based on the single objective optimization. The rated thermal efficiency is 32.8 % with 2229.7 kW power energy and 1045.7 kW cooling energy output based on multi-objective optimization. In addition, the power load can be regulated from 78.1 % to 111.8 %, and the corresponding cooling load is adjusted from 176.1 % to 58.7 %. Furthermore, the improvement of the component performance should focus on the steam turbine and evaporator. The trade-off strategy offers an original conception of the regulation method for an isolated system.

Обобщение формулы Аккермана для некоторого класса многомерных динамических систем с векторным входом

A compact analytical formula is obtained that determines the entire set of solutions of the modal control problem for a wide class of multidimensional dynamical systems with vector input, where the number of states is divisible by the number of control inputs, and the controllability index is equal to the quotient of this division. This formula generalizes to systems with the vector input the Ackermann formula applied to multidimensional systems with scalar input. The basis to obtaining the generalized Ackermann formula lies in the original concepts of the Luenberger generalized canonical form and operations of the matrices block transposition. For the most convenient calculation of controller, the original system with vector input is reduced to the generalized Luenberger canonical form using the two successive similarity transformations. A lemma is proved that demonstrates the compact analytical form of the inverse transformation matrix. Transition equivalence makes it possible to obtain a complete countably infinite parametrized set of solutions to the modal control problem under consideration. Its parametrization is provided by selecting block coefficients of the matrix polynomial, which determinant corresponds to the given scalar characteristic polynomial. In cases, where the matrix polynomial involved in parametrization is not reduced to the multipliers, the generalized Ackermann formula contains solutions to the modal control problem that could not be obtained using the existing decomposition method. Examples are presented demonstrating both suitability of the proposed formula for analytical synthesis of modal controllers by state in systems with vector input and its advantages in comparison with the decomposition method

The Man of Action of French Romanticism. Aesthetic Views of Victor Hugo and their Embodiment in Poetry and Dramaturgy

The subject of the study is the fundamental philosophical and aesthetic problems in the romantic aesthetics of one of its leaders in France - Victor Hugo. The evolution of his aesthetic views is traced - from adherence to the aesthetics of classicism and royalist views to the established theory and artistic practice of romanticism, colored with democratic pathos. The core of Hugo's aesthetics is revealed - the original concept of the grotesque, which has found a convincing embodiment in his poetry, drama, historical novels. Such main themes as the correlation of the tragic and the comic, the beautiful and the ugly, the sublime and the base, content and form, freedom and order, historical truth and fiction in art, romantic symbolization in the context of the formation of the concept of the artistic essence of romanticism by Hugo are considered. The features of his artistic and aesthetic concept related to the national specifics of art, local color, the problems of artistic taste, inspiration, imagination, aesthetic pleasure, artistic style, genius, talent are analyzed. The main conclusion of the study is the conclusion that all these topics form the basis of Hugo's judgments about the nature of romantic drama as the pinnacle of 19th century poetry and its differences from classic tragedy. The multidimensional nature of this study predetermined the use of a number of methodological approaches: philosophical and aesthetic approach, art history analysis, comparative, interdisciplinary methods. The author's special contribution lies in the fact that the study of Hugo's aesthetic theory and artistic practice is based on original material. The article provides a comparative analysis of the embodiment of Hugo's aesthetic views in various types and genres of art. Such a study was undertaken for the first time in domestic science.

Психологические особенности следователей с различными типами стратегий предварительного расследования уголовных дел

The article substantiates the original concept of the investigator's choice of a criminal investigation strategy based on the practical experience of the author's investigative work. According to the traditional approach in legal psychology, the investigator's activity is completely determined by the norms of the Criminal Procedure Code, and therefore does not represent the freedom of choice to the subject of the investigation. However, the author comes to the conclusion that such qualities of the subject as a tendency to risky behavior, the level of creativity, communicative and organizational abilities, tolerance to uncertainty and the type of behavior in conflict, influence the investigator's choice of a certain strategy for investigating a criminal case. The article attempts an empirical analysis of psychological resources to improve the effectiveness of the investigator.

Jovian Periodicities (~10 h, ~40, 20, 15 min) at ACE, Upstream from the Earth’s Bow Shock, on 25–27 November 2003

It is known that Jovian radio and high energy electron emissions are observed near Earth. The question we address in this study is whether the quasi-periodic ~10 h and ~40/15–20 min (QP-10 h, QP-40/15–20 min) energetic particle and magnetic field periodicities observed by Ulysses during its distant encounter with Jupiter in 2003 were also detectable as far as the Earth’s orbit. Surprisingly, we found that at the end of the extreme 2003 Halloween events, during times of a highly disturbed Jovian magnetosphere, as inferred from strong bKOM radio emissions observed by Ulysses, and a magnetic connection of Earth with the Jovian magnetosphere, as suggested by simulation results of the interplanetary magnetic field (IMF), the ACE satellite observed, between at least 25–27 November 2013 at the Lagrangian Point L1 (LPL1), all the characteristic Jovian periodicities. In particular, by using high-time resolution data (1/5 min), we found, for the first time, quasi-permanent electron, and magnetic field QP-10/5 h, QP-40 min and QP-15/20 data variations at LPL1 for at least three days. These observations reasonably suggest that low energy (~50–~300 keV) Jovian electrons reached the Earth’s environment; the observations examined extend the lowest energy limit of the Jovian electron spectrum from 200 keV to ~50 keV. In addition, the ACE satellite observed an impressive series of QP-10/5 h energetic (≤0.05 MeV) ion bursts (EIBs) with strong cross-field intensity gradients at the onset/decay phase of the events and energy-dependent field aligned anisotropy suggesting ion streaming in the anti-sunward direction during their main phase. A comparison of simultaneously obtained measurements by ACE at the LPL1 and by Geotail upstream from the bow shock and in the magnetosphere suggests that the QP-10/5 h EIBs are inconsistent with the concept of a terrestrial origin. On the contrary, the observations indicate that the series of QP-10/5 h EIBs on 25–27 November 2003 was a spatial effect caused by the ~10/5 h quasi-periodic approach of a large-scale sheet to the Earth’s environment. The source of the ion population forming the QP-10/5 h sharp EIBs seems most probably Jovian ions accumulated in the interplanetary space, although a solar ion contribution is possible. Based on the above results, it is reasonable to suggest that the observed QP-10 h, QP-40 min and QP-15/20 periodicities are due to Jovian influence. Further research is needed to study the cause of the QP-10/5 h EIBs. This study presents new data which extend our view on the influence of the QP-10 h/QP-40/QP-15/20 min Jovian emissions from the outer to the inner heliosphere at 1 AU.

Stanislavsky’s Failed Bildungsroman

Disabled for the last nine years of his life, Konstantin Stanislavsky struggled to verbalize his artistic experience and record it in writing. This experience mostly concerned acting, itself extremely hard to conceptualize and explain, and, to his mind, the core of human existence. Stanislavsky looked for the proper literary vehicle to contain this abundance. Initially, he hoped he had found adequate means in the form of the educational novel – the Bildungsroman. However, in the course of his writing, he gradually abandoned this form, as well as any literary aspirations he may have had. What we can find in An Actor’s Work are only remnants of the original concept. Nevertheless, they are still present. Looking closer at these ruins can bring interesting insights into the aura and mood of Stanislavsky’s theorizing about art.

Pragmatism or idealism: a systematic review and visual analysis of Winnicott's psychoanalytical treatment views.

Winnicott is an outstanding representative of the School of Object Relations, and his unique psychoanalytic treatment views have been greatly influential to the psychoanalytical community. Winnicott emphasizes the impact of facilitating environment and the key role of the maternal-child relationship in the early psychological growth of individuals. He puts forward the ideas of the development mechanism of the true self and the false self, which builds a bridge between the characteristics of adult psychopathology and the characteristics of early maternal-child relationships, providing a new perspective for research on individual self-development and psychoanalysis. Winnicott creatively introduces the concepts of the transitional object and the transitional phenomena into the theories of Object Relations. He relates the transitional experience to the field of mental health, and extends it from the relationship between the mother and the child to adult life, which not only has had a revolutionary impact on modern psychoanalysis but also literature, aesthetics, and other fields. Winnicott highlights the importance of the patient's emotional development in the treatment. He advocates holding the patients' sentiments and meeting their emotional needs. He also approves of the emotional reparenting of the patients, to make them gain the ability to establish a relationship with the real world. His treatment views formed through a large number of clinical practices are very practical and full of humanistic care. This review summarizes Winnicott's psychoanalytical treatment views as well as his marvelous original concepts, and analyzes the hot topics of academic research on his theories based on a visualization analysis by using the software CiteSpace, which includes data in the Web of Science Core Collection published from 1978 to 2023 with 365 papers involved. The study provides a macroscopic and panoramic review of Winnicott's theories, and it clearly shows Winnicott's significant influence on the field of psychoanalysis and related fields.