The article investigates the features of regional mechanisms of protection of the rights of persons with disabilities, created by intergovernmental organizations in the Asia-Pacific region; analyzes the main regional human rights documents in force in this area; highlights pressing issues of protection of the rights of this category of population, typical for the countries of Asia and the Pacific. Despite the interest of legal science in the field of disability, the issue of protecting the rights of persons with disabilities remains underresearched by regional international organizations. The methodological basis of the study is the comparative legal, formal legal methods. The work analyzes the international sources of regional organizations that have not previously been the subject of scientific research on the issues raised by this article. As a result of the study, the conclusion is drawn on the programmatic nature of international instruments of regional organizations in the Asia-Pacific region, the need for States to strengthen social policy taking into account the concept of ensuring the inclusion of the interests of persons with disabilities, the important role of the UN regional commissions in promoting the principles of inclusive society, enshrined in the UN Convention on the Rights of Persons with Disabilities
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