Oral Lymphoepithelial Cyst Research Articles

A RARE CASE OF ORAL LYMPHOEPITHELIAL CYST IN AN HIV-POSITIVE PATIENT: A TRUE ASSOCIATION OR AN OCCASIONAL FINDING?

The relationship between infection by human immunodeficiency virus (HIV) and oral lymphoepithelial cyst (OLC) is uncertain. Herein, we presented a rare case of OLC on the tongue in a male patient with HIV. Intraoral examination revealed a yellow nodular lesion with a smooth surface on the tongue's right lateral border measuring 0.8 cm. Medical history revealed that the patient had been diagnosed with HIV 1 month earlier and was being treated with antiretroviral therapy. An excisional biopsy was performed. Histopathologic examination showed a cystic lesion covered by squamous epithelium surrounded by a fibrous capsule containing dense lymphoid infiltrate with prominent germinal centers. The diagnosis was OLC. No evidence of recurrence was observed after 1 year of follow-up. Although rare, OLC can arise in the context of HIV infection. The treatment of choice is conservative surgical removal, and recurrence is uncommon.

ORAL LYMPHOEPITHELIAL CYST: A COLLABORATIVE CLINICOPATHOLOGIC STUDY OF 132 CASES FROM BRAZIL

<h3>Objectives</h3> To report the clinicopathologic features of 132 cases of the oral lymphoepithelial cyst (OLC). <h3>Study Design</h3> A retrospective descriptive cross-sectional study was performed. A total of 106,282 biopsy records of oral and maxillofacial lesions from 6 oral pathology services in Brazil were analyzed. All cases of OLCs were reviewed and clinical, demographic, and histopathologic data were collected. <h3>Results</h3> Among all lesions, there were 132 cases of OLC (0.11%). The series included 83 females (62.9%) and 49 males (37.1%), with a mean age of 45.8 ± 17.7 years (range, 04-88 years). Patients in the fifth and sixth decades of life were most affected (<i>n</i> = 24; 18.2% for both decades). Most cases involved the tongue (<i>n</i> = 80; 62.0%), followed by floor of the mouth (<i>n</i> = 32; 24.8%). Tumor size varied from 0.4 to 2.0 cm (0.45 ± 0.28) and most lesions were asymptomatic (<i>n</i> = 93; 91.2%). No recurrences were observed after surgical excision. <h3>Conclusions</h3> Clinical and demographic features were similar to those described in previous studies. Overall, this lesion has a predilection for the posterior region of the tongue of female adults.

Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil.

The oral lymphoepithelial cyst (OLC) is an uncommon lesion whose pathogenesis remains poorly understood. The aim of this study was to report the clinicopathologic features of the OLCs and to verify a possible association between OLCs and subgemmal neurogenous plaque (SNP) in the posterior lateral region of the tongue. A retrospective descriptive cross-sectional study was carried out. A total of 106,282 biopsy records of oral and maxillofacial lesions from six oral pathology services in Brazil were analyzed. All cases of OLCs were reviewed, and clinical and histopathological data were collected. Immunohistochemical reactions for S-100 protein were performed to confirm the diagnosis of SNP. Among all lesions, there were 132 (0.11%) cases of OLCs. The series comprised 83 females (62.9%) and 49 males (37.1%), with a 1.7:1 female-to-male ratio and a mean age of 45.8 ± 17.7 years. Most cases involved the tongue (n = 80; 62.0%) and presented clinically as asymptomatic papules or nodules with a yellow or whitish color. Microscopically, most of the cysts were entirely lined by parakeratinized stratified epithelium (n = 89; 67.4%) and filled with desquamated cells, keratin debris, amorphous eosinophilic material, and inflammatory cells in varying amounts. Connection with the epithelium of oral mucosa was observed in 18 cases (13.6%). SNP was found in 9/80 (11.2%) cases involving the tongue. The clinical and demographic features of OLCs were similar to those described in previous studies. Overall, this lesion has a predilection for the posterior region of the tongue of female adults. Clinicians must include the OLC in the differential diagnosis of yellow/white papules andnodules of the oral cavity.

Lymphoepthelial cyst of submandibular region: a case report

BackgroundThe oral lymphoepithelial cyst (LEC) is a rare, soft-tissue, developmental cyst, initially presented by Gold in 1962 as a “branchial cleft cyst”. It may occur in the pancreas, tongue, neck, and other regions of the oral cavity. No study has been reported in Pakistan and Karachi reporting a case of lymphoepithelial cyst in the submandibular region. This rare case of LEC has been reported to help the clinicians to bring LEC into their differential diagnosis for lesions affecting the submandibular region.Case presentationWe report a case of 57 years old female reported to the Maxillofacial OPD of a tertiary care hospital with the complaint of swelling on the right side of the neck for 3 weeks which was rapidly increasing in size. She was having difficulty in mastication. On extra-oral examination, there was swelling on the right side in the submandibular area. The overlying skin is normal with no evidence of pus and discharge. On palpation, the swelling was soft, non-tender, non-fluctuant, non-displaceable into the submandibular area. Lymph nodes were impalpable. Excision of the lesion performed under general anesthesia and biopsy revealed lymphoepithelial cyst associated with submandibular gland. Here we present an attention-grabbing case of swelling in the right submandibular region which was provisionally diagnosed as a malignant submandibular lymph node however later evidence histopathologically as a lymphoepithelial cyst of the submandibular gland.ConclusionAn unusual cause of swelling in the neck is lymphoepithelial cysts. Submandibular gland appearance is not usual and can prove to be a clinical problem.

Spontan düzelen konjenital oral lenfoepitelyal kist: Olgu sunumu

Oral lymphoepithelial cyst is a rare benign cystic lesion affecting the oral cavity; mainly the floor of the mouth. It was reported to affect patients with a wide age range extending from childhood to geriatrics. It is treated by conservative surgical excision with excellent prognosis. A case of 2-month old infant presented with a congenital asymptomatic white dome-shaped swelling in the floor of the mouth. The lesion was reported to resolve spontaneously with no intervention. To the best of our knowledge, this is the first report of a congenital oral lymphoepithelial cyst. We recommend the follow up of the cases of infants and children as resolution may occur spontaneously with no need for intervention.

Epidemiological evaluation of jaw cysts according to the new WHO classification: a 30-year retrospective analysis.

The aim of the present study was to analyze the epidemiology of maxillofacial odontogenic and non-odontogenic cysts diagnosed for 30 years in a Brazilian population. A retrospective descriptive cross-sectional study was performed. Biopsy records were obtained from the archives of a Brazilian referral center between 1989 and 2019. Data regarding age, gender, anatomical location, and histopathological diagnosis were collected and categorized. Further, a literature search for similar studies was performed. A total of 6.994 biopsy records were evaluated, but only 367 (5.24%) cases were classified as odontogenic cysts (OC) or non-odontogenic cysts (NOC). Among all cystic lesions, 341 cases (92.9%) were OC and 26 cases (7.1%) were NOC. These lesions were more common in females (n = 208 / 56.67%) and located mostly in the mandible (n = 195 / 53.1%). In patients with OC, the radicular cyst was the most frequent (n = 134 / 36.5%), followed by the dentigerous cyst (n = 101 / 27.5%) and the odontogenic keratocyst (n = 52 / 14.2%). Patients with NOC had a higher frequency of epidermoid cyst (n = 12 / 3.3%), oral lymphoepithelial cyst (n = 7 / 1.9%), and nasopalatine duct cyst (n = 4 / 1.1%). The OCs were more prevalent than NOCs, and inflammatory cysts were the most common among all the OCs.

ORAL LYMPHOEPITHELIAL CYST: A MULTICENTRIC STUDY OF 77 CASES

Objective: To analyze the frequency and clinical and demographic features of oral lymphoepithelial cyst (OLEC) from 5 Brazilian services of oral and maxillofacial pathology. Study Design: Ethical approval (80249117.0.0000.5149). A cross-sectional retrospective study was conducted in 5 oral pathology services. The biopsy records were reviewed from 1952-2018. Cases with a microscopic diagnosis of OLEC were retrieved. Hematoxylin-eosin slides were reviewed by a single pathologist to confirm the diagnosis. Lesions of major salivary glands were excluded. Frequency and clinical and demographic data were analyzed descriptively. Results: Seventy-seven OLECs were found, representing 0.05% of the lesions submitted to diagnosis in the centers (n = 146,150). OLEC was predominantly diagnosed in females (n = 54; 70.1%). The mean age was 46.51 years (range [SD], 13-84 [14.80]). Lesions arose mainly in the tongue, lateral border (n = 31; 40.3%). The lesions measured up to 1 cm in size (n = 47; 61.0%) and were asymptomatic (n = 50; 64.9%). Twenty-four cases (31.2%) were white in color. Conclusion: OLECs are very uncommon diagnoses in oral pathology services. Lesions usually affect women, are small and asymptomatic, and located in the lateral border of the tongue. Detailed microscopic and immunohistochemical features will be accessed in the next step of this study. Support: CAPES, FAPEMIG, CNPq. Objective: To analyze the frequency and clinical and demographic features of oral lymphoepithelial cyst (OLEC) from 5 Brazilian services of oral and maxillofacial pathology. Study Design: Ethical approval (80249117.0.0000.5149). A cross-sectional retrospective study was conducted in 5 oral pathology services. The biopsy records were reviewed from 1952-2018. Cases with a microscopic diagnosis of OLEC were retrieved. Hematoxylin-eosin slides were reviewed by a single pathologist to confirm the diagnosis. Lesions of major salivary glands were excluded. Frequency and clinical and demographic data were analyzed descriptively. Results: Seventy-seven OLECs were found, representing 0.05% of the lesions submitted to diagnosis in the centers (n = 146,150). OLEC was predominantly diagnosed in females (n = 54; 70.1%). The mean age was 46.51 years (range [SD], 13-84 [14.80]). Lesions arose mainly in the tongue, lateral border (n = 31; 40.3%). The lesions measured up to 1 cm in size (n = 47; 61.0%) and were asymptomatic (n = 50; 64.9%). Twenty-four cases (31.2%) were white in color. Conclusion: OLECs are very uncommon diagnoses in oral pathology services. Lesions usually affect women, are small and asymptomatic, and located in the lateral border of the tongue. Detailed microscopic and immunohistochemical features will be accessed in the next step of this study. Support: CAPES, FAPEMIG, CNPq.

ORAL LYMPHOEPITHELIAL CYST IN FLOOR OF MOUTH: A CASE REPORT

Oral lymphoepithelial cyst (OLC) is a rare developmental cyst of soft tissue. Clinically, OLC exhibits as a small and asymptomatic mass, with color ranging from rose to yellowish. OLC develops manly in floor of mouth and lateral and ventral surfaces of tongue. Based on this, we aimed to report a case of OLC in a young patient. A 17-year-old male patient presented a painless nodular aspect located in floor of mouth with a history of evolution of 2 months. Clinical hypothesis was ranula. Excisional biopsy was performed, and histopathologic analysis revealed a cystic cavity lined by keratinized stratified epithelium; cystic lumen showed desquamated epithelial cells. Cystic capsule was composed of connective tissue exhibiting numerous lymphocytes, sometimes arranged in germinal centers. Superficially, epithelium of oral mucosa was observed. Based on pathologic findings, final diagnosis was OLC. After 12 months of follow-up, no sign of recurrence was observed. Oral lymphoepithelial cyst (OLC) is a rare developmental cyst of soft tissue. Clinically, OLC exhibits as a small and asymptomatic mass, with color ranging from rose to yellowish. OLC develops manly in floor of mouth and lateral and ventral surfaces of tongue. Based on this, we aimed to report a case of OLC in a young patient. A 17-year-old male patient presented a painless nodular aspect located in floor of mouth with a history of evolution of 2 months. Clinical hypothesis was ranula. Excisional biopsy was performed, and histopathologic analysis revealed a cystic cavity lined by keratinized stratified epithelium; cystic lumen showed desquamated epithelial cells. Cystic capsule was composed of connective tissue exhibiting numerous lymphocytes, sometimes arranged in germinal centers. Superficially, epithelium of oral mucosa was observed. Based on pathologic findings, final diagnosis was OLC. After 12 months of follow-up, no sign of recurrence was observed.

ORAL LYMPHOEPITHELIAL CYST: RETROSPECTIVE ANALYSIS OF 41 CASES AND REPORT OF A CASE AT AN UNUSUAL LOCATION

Objective To investigate the clinical and demographic characteristics of oral lymphoepithelial cyst. Study Design The files of an oral pathology service were reviewed for cases diagnosed as oral lymphoepithelial cyst. Data of patient sex, age, lesion location, clinical presentation, and clinical diagnosis were collected. Descriptive statistics were done. Results Forty-one cases of oral lymphoepithelial cysts were found among 36,359 archived specimens (0.11%). Lesions affected mainly women (73.2%) and persons of white ethnicity (53.7%), with a mean age of 46 years (range, 13-70), appearing mostly as an asymptomatic lesion at the tongue border (29.3%) and floor of the mouth (19.5%). Among 41 lesions, 25 (61%) measured less than 1 cm; 28 (68.3%) were whitish or had coloration similar to the surrounding mucosa. In 19 cases (46.3%), clinical diagnosis was not oral lymphoepithelial cyst, and fibrous hyperplasia and mucocele were commonly cited (12.2% each). Additionally, a case arising on the hard palate of a 69-year-old man is presented. Conclusion Oral lymphoepithelial cysts are uncommon lesions. The clinical and demographic data found herein are in accordance with previous reports. Support: FAPEMIG.

Clinical-pathological aspects of oral lymphoepithelial cyst: case report

ABSTRACT Oral lymphoepithelial cyst (OLEC) is an uncommon lesion whose pathogenesis remains poorly understood. The purpose of this paper is to report a case of OLEC. Female patient, white, 62 years old, presented asymptomatic nodular swelling of soft consistency in the lateral border of the tongue. Under the clinical hypothesis of lymphoid tissue hyperplasia, an excisional biopsy was performed. Histopathological examination revealed a pathological epithelial-lined cavity and a cystic connective tissue capsule containing lymphoid tissue. The diagnosis of OLEC was established and the patient showed no signs of recurrence after surgical removal of the lesion.

Clinicopathological and immunohistochemical features of the oral lymphoepithelial cyst: A multicenter study.

Analyze the clinical, demographic, histopathological, and immunohistochemical features of oral lymphoepithelial cyst (OLEC). Samples were retrospectively retrieved from five oral pathology services. Clinical and demographic data were collected from patient charts. Histopathological and immunohistochemical (CD3 and CD20) features were evaluated. Data analysis involved descriptive statistics and bivariate analyses (P≤.05). Seventy-seven cases were found among a total of 146150 specimens (0.05%). OLEC was predominantly diagnosed in females (70.1%). Mean patient age was 46.51years. The lesions arose mainly on the lateral border of the tongue (40.3%), measured up to 1cm (61.0%), and were asymptomatic (64.9%). Twenty-four lesions (31.2%) were white. Forty-one cases (53.2%) presented lymphocytic inflammatory infiltrate with no specific arrangement. The cystic lining was composed of a non-keratinized stratified epithelium (59.7%) presenting hyperplasia (39.0%). Connection with the surface, epithelium was found in 23 cases (29.9%) and 31 (40.3%) cases had two or more cystic cavities. The lumen content was predominantly desquamated cells (48.1%). Subgemmal neurogenous plaque was found in 11/42 (26.2%) cases involving the tongue. CD20+ cells predominated in 36/63 cases (57.2%), and lymphocytic inflammatory infiltrate was not always continuous around the cystic cavity (52.4%). Lymphoepithelial cyst is an uncommon lesion of the oral cavity. The present study offers the largest sample of OLEC for which clinical, demographic, histopathological, and immunohistochemical features were evaluated. The clinical and demographic findings were similar to those described in previous reports, but the microscopic analyses revealed interesting aspects of the cystic epithelium and the lymphocytic inflammatory infiltrate in OLEC.

ORAL LYMPHOEPITHELIAL CYST ASSOCIATED WITH SUBGEMMAL NEUROGENOUS PLAQUE—CASE REPORT

Oral lymphoepithelial cyst (OLC) is an unusual lesion with uncertain pathogenicity. OLC has a discreet preference for men and it is frequently reported on the lateral and ventral tongue surface. Subgemmal neurogenous plaque (SNP) is a biphasic neural structure associated with the taste buds. It has a discreet predilection for women and is clinically characterized as a nodule, commonly located on the posterior lateral tongue surface. The aim of this study is to report a case of OLC associated with SNP, its clinical-pathologic characteristics, and treatment. A 53-year-old white woman, smoker, with no systemic involvement, presenting with a lateral tongue asymptomatic nodular lesion, sought help. An excisional biopsy was performed and showed it was OLC associated with an SNP. The patient is being followed and 1 year after the surgery, no recurrence could be observed. The authors believe this is the first case showing an association of OLC and SNP. Oral lymphoepithelial cyst (OLC) is an unusual lesion with uncertain pathogenicity. OLC has a discreet preference for men and it is frequently reported on the lateral and ventral tongue surface. Subgemmal neurogenous plaque (SNP) is a biphasic neural structure associated with the taste buds. It has a discreet predilection for women and is clinically characterized as a nodule, commonly located on the posterior lateral tongue surface. The aim of this study is to report a case of OLC associated with SNP, its clinical-pathologic characteristics, and treatment. A 53-year-old white woman, smoker, with no systemic involvement, presenting with a lateral tongue asymptomatic nodular lesion, sought help. An excisional biopsy was performed and showed it was OLC associated with an SNP. The patient is being followed and 1 year after the surgery, no recurrence could be observed. The authors believe this is the first case showing an association of OLC and SNP.

ORAL LYMPHOEPITHELIAL CYST: A CASE REPORT

A 62-year-old female patient was referred for an evaluation of an asymptomatic lesion of approximately 2 years’ duration. The patient presented with a nodule on the ventral surface of the tongue, with a sessile base, smooth, and with nonulcerated overlying mucosa but with a slightly yellow coloration. An excisional biopsy was performed. In the macroscopic examination, the sample was divided symmetrically, causing the sample to release a dense whitish secretion. Microscopically, a cystic cavity was observed and delineated by a parakeratinized stratified squamous epithelium. The cystic wall was constituted by lymphoid tissue with randomly arranged germinal centers. Keratin and desquamated epithelial cells were present in the cystic lumen. With these findings, the diagnosis was oral lymphoepithelial cyst. In the following controls, a postoperative wound is observed in the process of normal healing. The case is reported under the informed consent of the patient.

Verruciform Xanthoma, a Rare Lesion Located on the Left Lateral Border of the Tongue: a Case Report

Verruciform xanthoma is a benign mucocutaneous lesion of unknown etiology characterized by the accumulation of histiocytes filled with lipids, below the epithelium; it may represent an unusual reaction or immune response to trauma or local epithelial damage. It typically affects the oral cavity, specifically the gum region and alveolar mucosa. The aim of this study was to report the case of a 58-year-old man with leukoderma with a circumscribed papillary lesion with verruciform surface and yellowish-color, located on the left lateral border of the tongue, in the region of the foliaceous papillae, of approximately 1 cm in diameter. During anamnesis, the patient reported habits of alcoholism and smoking in the past, with a history of cold sore and squamous papilloma in the oral cavity. The initial diagnostic hypothesis of oral lymphoepithelial cyst was replaced, after excisional biopsy, with an anatomopathological report of verruciform xanthoma, which is considered a rare lesion.

ORAL LYMPHOEPITHELIAL CYST: CASE REPORT

Oral lymphoepithelial cyst (OLC) is a rare lesion of the mouth that develops within lymphoid tissue. The lesion presents as an asymptomatic, well-circumscribed, yellowish small submucosal nodule covered by normal overlying mucosa, usually located on the floor of the mouth or in the tongue. Histopathologic examination reveals a cyst lined by stratified squamous epithelium surrounded by lymphoid tissue. OLC should be treated with surgical excision and should not recur. A 30-year-old white female patient attended the Oral Medicine clinic complaining of a lesion on the tongue that had increased in size over the last year. Extraoral examination showed no abnormality. Intraoral examination revealed a symptomatic firm white-yellowish nodule on the posterolateral surface of the left side of the tongue. The diagnostic hypotheses were oral lymphoepithelial cyst and granular cell tumor. An excisional biopsy was performed and microscopic examination confirmed the diagnosis of OLC. After 1 year no recurrence was observed.

Oral lymphoepithelial cyst: A case report

14.00 Normal 0 false false false EN-US X-NONE X-NONE The lymphoepithelial cyst is an uncommon lesion in the mouth. It develops within a benign lymphoid aggregate or accessory tonsil of the oral or pharyngeal mucosa. The usual presentation is of a round or oval swelling of the oral mucosa of normal color. Intraoral lymphoepithelial cysts affect mainly the floor of the mouth followed by the ventral and posterolateral surface of the tongue. Very few cases have been reported occurring on the soft palate, anterior palatine pillar and buccal vestibule. The present paper describes lymphoepithelial cyst on the soft palate and adds another case to the few cases in literature.

Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature.

IntroductionΤo describe the clinicopathological features of 26 oral lymphoepithelial cysts (LECs) and review the literature.Material and MethodsTwenty-six cases of oral LECs diagnosed during a 37-year period were retrospectively collected. The patients’ gender and age, as well as the main clinical features of the cysts were retrieved from the requisition forms. The main microscopic features were recorded after reevaluation of all cases. Pubmed and Google Scholar electronic databases were searched with the key word “oral LEC”. Inclusion criteria were the microscopic confirmation of LEC diagnosis and the report at least two of three main clinical features (gender, age and cyst’s location).ResultsThe 26 oral LECs represented 0.08% of 31,564 biopsies accessioned during the study period. They affected 25 patients, 14 females and 11 males with a mean age of 33.04±9.81 years. They appeared as smooth (92%) nodules, with soft (24%) or firm (76%) consistency and normal (28%), yellow to normal (20%), yellow (32%) or white (20%) hue, in the tongue (69.23%) or the floor of mouth (30.77%). They were covered by parakeratinized squamous (92.31%) or non-keratinized (7.69%) epithelium and contained desquamated epithelial cells, amorphous eosinophilic material and/or inflammatory cells (100%). The lymphoid tissue surrounded the cystic cavity partially (34.62%) or completely (65.38%), often in a follicular pattern with prominent germinal centers (53.85%). Literature review yielded 316 cases of oral LECs derived from 25 case reports, 3 case studies/retrospective studies with detailed information for each case and 7 studies with summarized data.ConclusionsOral LEC is a pathologic entity with discrete clinical presentation that is, however, commonly misdiagnosed in clinical practice as other, mostly benign, entities. Its pathogenesis remains obscure, as its clinicopathologic features are consistent with both theories suggested up to date. Key words:Oral lymphoepithelial cyst; developmental cyst; non odontogenic cyst; lymphoid tissue; oral tonsil.

Lymphoepithelial cyst on the tongue: case report at unusual location

ABSTRACT Oral lymphoepithelial cyst (OLEC) is an uncommon lesion that develops in oral lymphoid tissue. The aim of the present study was to report a clinical case of OLEC in the tongue. A 22-year-old patient presented a nodular lesion, yellowish, with a softened consistency, measuring 0.5 cm in the ventral surface of the tongue. Under the clinical hypotheses of mucocele and OLEC, excisional biopsy was performed. The histopathological examination revealed a cystic lesion covered by a parakeratinized stratified squamous epithelium, which presented in its fibrous capsule a prominent lymphoid tissue. Based on the definitive diagnosis, surgical excision of the lesion was performed.

Oral Lymphoepithelial Cyst With Unusual Clinical Presentation: A Case Report

Oral Lymphoepithelial Cyst With Unusual Clinical Presentation: A Case Report

Oral Lymphoepithelial Cyst: Report of 2 Cases

Oral Lymphoepithelial Cyst: Report of 2 Cases