The article is devoted to identifying the current principles of designing architectural objects based on pneumatic air-supported structures in extreme conditions using the example of the Covid-19 pandemic. The object of the research is project proposals and realized pneumatic buildings and structures of the XXI century, created during the period of the Covid-19 epidemic. The objective of the study is to identify the basic principles for improving the design concepts of pneumatic air-supported objects in a pandemic and post-pandemic period in the context of international architectural and engineering trends to predict the vector of their further development. The methodological approach to the study of these problems is based on a systematic analysis of the features of the formation of pneumatic structures and is based on the materials of the implemented and designed buildings and structures of pneumatic architecture, as well as the study of open domestic and foreign scientific publications in this area. The findings of the study demonstrate the key advantages of using pneumatic air-supported structures in the creation of architectural buildings and structures based on the identified design principles, considering modern measures of epidemiological safety. The results obtained can be useful for architects, designers and engineers.