Abstract The paper describes tests to determine the leakage behavior of inflatable seals when subjected to containment pressures that exceed the design basis. 2 Inflatable seals are used to prevent leakage around personnel and escape lock doors in about 10% of the commercial nuclear power plant containment structures in the United States. All of the installations are in either Pressurized Water Reactor (PWR) or Boiling Water Reactor (BWR) Mark-Ill type containments. This work is a part of an overall effort at Sandia National Laboratories to develop proven techniques for evaluating the performance of Light Water Reactor (LWR) containment buildings for beyond design basis loadings. Inflatable seals were tested at both room temperature and at elevated temperatures representative of postulated severe accident conditions. Parameters that were monitored and recorded during each test were the internal seal pressure and temperature, chamber (containment) pressure, leakage past the seals, and temperature of the test chamber and fixture to which the seals were attached. An empirically based, analytical method is presented to predict the containment pressure at which significant leakage past inflatable seals can be expected.