Neuropsychic Development Research Articles

Development of an early comprehensive care system for children with disabilities in educational and healthcare institutions

Development of an early comprehensive care system for children with disabilities in educational and healthcare institutions

Влияние окислительного стресса на нейротоксический эффект ацетаминофена

Paracetamol (acetaminophen, APAP) is a commonly-used antipyretic and analgesic. However, there have been reports indicating possible link between its use in pregnancy and impaired neuropsychic development in children. A number of prospective studies of the possible negative effect of acetaminophen on the development of a child after his mother took this drug during pregnancy, as well as the results of studies on glioma cells and neurons in murine cortex, may indicate presence of the neurotoxic effect of acetaminophen. It is currently unclear if paracetamol itself being pharmacologically active neurotropic substance, or its metabolites, one of which – NAPQI (N-acetyl-p-benzoquinone imine) known by its toxic effects in mitochindria, play the most significant role in proposed neurotoxicity. Therefore it seems important to study each metabolite separately. The ability of acetaminophen(paracetamol) in concentrations of 1 mg/ml and 2 mg/ml to reduce cell viability was shown on cells of the PC12 neuronal line using MTT-method, which is based on the ability of mitochondria of viable cells to restore formazan 3-(4,5-dimethylthiazole)-2,5-diphenyl-2-tetrazolium bromide (MTT). Concentrations of 0.125 mg/ml, 0.25 mg/ml and 0.5 mg/ml had no similar impact on cell culture viability. In addition, the impact of hydrogen peroxide (as an inducer of oxidative stress) on the neurotoxic effect of acetaminophen was studied. We demonstrated that in the presence of 0.3 mM or 0.5 mM hydrogen peroxide and acetaminophen in concentrations of 1 mg/ml and 2 mg/ml reliably reduced the percentage of surviving cells. We showed that the decrease of the viability of the cells of the PC12 neuronal line is obvious only after exposure to high concentrations of acetaminophen, especially in the presence of hydrogen peroxide, which means that neurotoxic effect is not likely to occur in vivo.

Vitamins А, С and D — Essential Trio for Infants

Administration of essential vitamins A, C and D in vitamin-mineral complex in common dosage is efficient for immunity formation, harmonious physical and neuropsychic development, rickets prevention. Dosage of components at the physiological daily maintenance in basic vitamin complexes for infants is integral for nursing mother supplementation and fortification of the food used for infant weaning. If necessary, and specifically in immature infants, the basic vitamin complex (vitamins A, C and D) can be extended with other required micronutrients (vitamin D, for example, can be extended up to 1000 ME). It depends on feeding type, intake of vitamin-mineral complexes for nursing mothers, seasonal prevalence, region and many other factors.

Essential vitamins deficiency in children under one year

The article provides information on the main groups of vitamins and their effects on the child’s body. The negative effect of the macroand micro-elements deficit on the human body, both of the adults and children, has been proved convincingly. The essential triad of vitamins (A, C, D,) is the most significant vitamins for children under one year. This combination of vitamins ensures the safety of the combination and the possibility of mutual supplement of ingredients for effective formation of infant immunity, neuropsychic development, harmonious physical development and prevention of rickets. The vast majority of children under one year have an essential vitamins A, C, D deficiency, regardless of the nature of feeding. The Russian studies showed that only 45.6% of children have an adequate vitamin D level. It is also proven that children with atopic dermatitis have low vitamins A, C, and E levels.

NEW APPROACHES TO HELPING CHILDREN AT THE CHILDREN’S CITY ADVISORY-DIAGNOSTIC CENTER

There are presented data of a comprehensive study of the health status of schoolchildren, there is given the characteristics of their physical and neuropsychic development, as well as the morbidity rate of children, with taking into account sequellae of perinatal lesions of the central nervous system. In children with chronic somatic pathology, neurological disorders and disorders of the psychoemotional sphere were established to be often detected. This determines the need for a comprehensive neuro- and psychosomatic approach to their treatment and rehabilitation. One of the forms of personification of medical and social assistance for such children was shown to be a modular approach allowing form complex programs consisted of these modules for correction of various health disorders. The use of these modules has prospects, as it optimizes the activity of consulting and diagnostic centers.

The health status of children born after in vitro fertilization in their first 12 months of life

To study the health status of children of the first 12 months of life born after in vitro fertilization from single and multiple pregnancies, the authors analyzed obstetric and gynecological anamnesis of mothers, peculiarities of the procedure of extracorporal fertilization, the results of a prospective clinical observation of children under 1 year with the assessment of physical, neuro-psychological development, morbidity and disability. It was found that multiple pregnancy due after in vitro fertilization is a risk factor for preterm birth, birth of children with low body weight and the formation of perinatal pathology. Children born from a single pregnancy after in vitro fertilization, at the age of 1 year did not differ from children born from spontaneous pregnancy, in terms of physical and neuropsychological development parameters, and absence of disability. Morbidity, disability, physical and neuropsychic development of children with a birth weight of less than 1,500 g from multiple pregnancies after in vitro fertilization did not differ from children from multiple natural pregnancies in the first 12 months of life. The procedure of in vitro fertilization is not a negative factor for the formation of the health of children born from single and multiple pregnancies. In this regard, the multiple pregnancy and the associated prematurity is the main factor affecting the health of children born after in vitro fertilization.

Woman and Child: The Penitentiary Aspect

The article analyzes the legal and medical significance of the child's living together with his mother in the Children's Houses of the penitentiary system. Materials for the study were the author's own observations, the materials of the Federal Service for Execution of Punishment (FSEP) of Russia reports on medical care for women and children over the period of five years; the data obtained as a result of targeted inquiries to the Children's Houses of the penitentiary system. The article generalizes the experience of the Children's House activities of the penitentiary system in this direction. It shows the positive effect of joint maintenance, first of all, in terms of the breastfeeding rates. Natural and mixed feeding constituted 67 % in the Children's Houses, including 85 % in the Children's Houses with joint stay of the newborns, and 42 % in other Children's Houses, which is statistically lower. In the Children's Houses with the expanded co-residence department, the primary morbidity of children was 1678 ‰, while in the comparison group - 2015 ‰, which is significantly higher. According to the primary incidence rate, there was a decrease in the pool of respiratory diseases from 1000 to 870 per 1000 children, thanks to placing into operation of the joint co-residence hostel for mother and child. The co-residence of the mother, convicted to imprisonment, and the newborn will contribute to the childs physical, neuropsychic development, its harmonious growth, as well as to manifesting the maternity feelings, which can be an important factor of the resocialization of the convicted person. The author propose to introduce a normative compulsory co-residence of mother and child in the Children's Houses of the penitentiary system.

Febrile seizures: what pediatricians should know

Febrile seizures are the age-dependent and predictively favorable condition, which is observed in children under 6 years. All febrile seizures are divided into simple (2/3 of all cases), complex and febrile status. Complicated seizuresinclude attacks with focalsymptoms, prolonged and recurring throughout the day. Simple febrile seizures are short, generalized, not repeated. Simple seizures do not harm the child’s neuropsychic development, they do not transform into epilepsy, and do not need chronic prescription of anticonvulsant therapy. A child with normal development and simple febrile seizures does not need an obligatory EEG and MRI of the brain. All the patients of 18 months old or less with the first episode of febrile seizures need to be hospitalized. The risk of recurrence of seizures and their transformation into epilepsy is higher in a child with complex seizures. There is a small group of children with prolonged seizures and / or febrile status, often with neuropsychiatric developmental delay, which needs to be monitored by a neurologist and further examination. Sometimes doctor prescribes long-term anticonvulsant therapy for the children of this group. Febrile seizures can be prevented with special dosage of anticonvulsant drugs quickly reaching a therapeutic concentration in the child’s brain. Febrile seizures are not a contraindication to vaccination and revaccination, attention should be paid in case of DTP vaccination in children with repeated prolonged seizures and / or febrile status.Conflict of interest: The author of this article confirmed the lack of conflict of interest and financial support, which should be reported.

Влияние комплексной терапии с включением неспецифической иммунокоррекции беременных женщин с сахарным диабетом 1 типа на состояние здоровья их детей

Цель. Влияние комплексной терапии с включением неспецифической иммунокоррекции (ингаляции гепарина в гестационном периоде у женщин с сахарным диабетом 1-го типа (СД1) с установленной гиперпродукцией аутоантител к инсулину и его рецепторам), на здоровье рожденных ими детей. Материалы и методы. Проведен сравнительный анализ нервно-психического развития, соматического состояния и иммунологических особенностей у детей от рождения до 3 лет от матерей с СД1, получавших традиционную терапию (основная группа, n = 101) и детей от матерей с СД1, получавших во время беременности в составе комплексной терапии ингаляции гепарином (экспериментальная группа, n = 40). Контрольную группу (n = 30) составили дети от соматически здоровых матерей без инфекционной и эндокринной патологии. Результаты. При анализе частоты регистрируемой у детей в период новорожденности патологии ЦНС установлено увеличение данного показателя по сравнению с контролем обеих группах детей, рождённых от матерей с СД1. Однако по результатам балльной оценки (методика «ГНОМ») выявлено, что в экспериментальной группе было достоверно больше здоровых детей и, наоборот, меньше детей с патологией нервной системы, нуждающихся в лечении. При этом что уровень антител к инсулину у детей экспериментальной группы в возрасте 1 год оказался значимо ниже (р < 0,05), чем в основной группе. Заключение. Своевременное применение неспецифической иммунокоррекции в период беременности в составе комплексной терапии беременных женщин с СД1 позволяет нормализовать уровень органоспецифических аутоантител, улучшить клиническое состояние новорожденных детей и прогноз их последующего неврологического развития. Aim. To study the effect of a complex therapy including a nonspecific immune correction (heparin inhalation in the gestational period of women with type 1 diabetes mellitus (DM1) with documented overproduction of insulin and insulin receptor autoantibodies) on the health of their children. Methods. A comparative analysis of neuropsychic development, somatic status, and immunological features was performed in children from birth to three years born by mothers with DM1 who received a standard complex therapy (main group, n = 101) and children from mothers with DM1 who received heparin inhalation as a part of the complex therapy during pregnancy (study group, n = 40). The control group (n = 30) consisted of children from somatically healthy mothers without infectious and endocrine pathology. Results. Analysis of the incidence of CNS pathology observed in newborns during the neonatal period showed an increase in this index in both groups of children born from mothers with DM1 compared to the control. However, according to the results of scoring (GNOM method) the number of healthy children was significantly greater whereas the number of children with CNS pathology who needed treatment was significantly less. Moreover, the level of insulin antibodies was significantly lower (p <0.05) in children of the experimental group at the age of one year than in the main group. Conclusion. The timely use of nonspecific immune correction as a part of the complex therapy of pregnant women with DM1 allows to normalize the level of organ-specific autoantibodies, improve both the clinical condition of newborns and the prediction for their subsequent neurological development.

PREMATURITY AND LOW BIRTH WEIGHT AS RISK FACTORS FOR NEURODEVELOPMENTAL DISORDERS IN CHILDREN

The introduction of modern technologies and the widespread use of intensive care in neonatology have led to an increase in the survival rate of children, who were born deeply premature with a low, very low, and extremely low body weight. The purpose of the study: evaluation of the peculiarities of neuropsychic development and the frequency of occurrence of neuropsychiatric disorders by the age of 5-8 years in children, who were born deeply premature with extremely low, very low, and low body weight in comparison with healthy peers. We examined 122 patients aged from 5 years 0 months to 8 years 0 months, 36 were born with very low body weight, 36 with extremely low body weight, 50 with low body weight, and 30 children were included into the control group. To assess the main complaints in patients, a structured questionnaire for parents was used. To study emotional and behavioral disorders in children, T.Achenbach’s structured questionnaire for the parents was used. Results and discussion. Data from the T.Achenbach’s parents’ questionnaire indicated significantly more expressed and pronounced manifestations of isolation, psychosomatic disorders, anxiety, problems of socialization and thinking, attention disorders, problems of behavior and aggressiveness in the examined children. In the groups of the examined patients, compared with peers, were significantly higher scores on the scales of “Internalizing manifestations” and “Externalizing manifestations”. It was shown that profound prematurity and birth with extremely low, very low and low body weight are important predisposing factors for the neurodevelopmental disorders in children: autism spectrum disorders, attention deficit hyperactivity disorder, developmental dyspraxia, specific learning difficulties. Early diagnosis of these conditions determines the effectiveness of therapeutic measures with the need of individual approach and comprehensive medical-psychological-pedagogical support.

Факторы риска сохранения задержки нервно-психического развития у детей раннего возраста в пер- вый год воспитания в замещающей семье

Факторы риска сохранения задержки нервно-психического развития у детей раннего возраста в пер- вый год воспитания в замещающей семье

Risk factors causing persistent delay in neuro-psychic development in infant children during their first year in a foster family

Risk factors causing persistent delay in neuro-psychic development in infant children during their first year in a foster family

The Medical Social Efficiency of Joint Confinement of Mother and Child in Place of Imprisonment

The article, on the basis of the results of study of 2016, analyzes a comparative medical social effect of conjoint and separate residing of mother and child in the Children's Homes of the Penal Enforcement System. The materials of study consisted of original observations while working in the given system, data of reports of the Federal Penitentiary Service of Russia concerning medical care of women and children in 2011-2015 and data of address requests to the Children's homes under correctional facility in 2013 and 2015. The experience of functioning of the Children's homes of penitentiary system is summarized. The positive effect of conjoint keeping to indices of coverage with breast feeding is established. The coverage of natural and mixed feeding amounted to 65% in Children's Homes, including 83% in Children's Homes with conjoint residing of mother and child in Children's Homes and in other Children's Homes -- 43% (p<0.05). In 2015, a single refusal of child by condemned mother occurred in Children's Homes, while in 2013 there were 4 of such refusals (p<0.05). In Children homes with extended department of conjoint residence primary morbidity of children made up to 1,679‰ and in comparison, group -- 2014‰ that is reliably higher (p<0.05). According data of primary morbidity occurred decreasing of pool of diseases of respiratory organs from 1,002 to 872 per 1,000 children due to brining into operation of dormitory of conjoint residence of mother and child. This occurrence resulted in decreasing per 12% of number of hospitalizations by emergency indications. The conjoint residence of condemned mother and newborn results in harmonious growth, physical, neuropsychic development of child and also in development of motherhood feelings that is an important factor of re-socialization of the condemned woman. It is proposed to introduce normatively obligatory conjoint residence of mother and child in Children's homes of the Penal Enforcement System.

Clinical effectiveness study of transcranial direct current stimulation in amblyopic children

to assess the neurophysiological effect and clinical effectiveness of transcranial direct current stimulation in combination with drug therapy in amblyopic children. The study involved 32 healthy children in the age of 5-12 years and 97 patients of the same age with refractive strabismic amblyopia. All study subjects underwent standard examination including ophthalmological (visometry, refractometry in normal conditions and in cycloplegia, biomicroscopy, ophthalmoscopy, type of vision), neurophysiological methods (determination of retinal electric sensitivity threshold, electric lability of optic nerve, amplitude and latency period of visual evoked potentials, electroencephalogram wave amplitudes, localization of peak electrical activity area of the cerebral cortex), assessment of neuropsychic development and estimation of mental development coefficient with age tests. Dynamics of neurophysiological parameters shows that healthy children develop fully functional retina, visual cortex and cortical-subcortical connections by 12 years. Children with refractive strabismic amblyopia in all age groups show statistically significant (р<0.05) deterioration of neurophysiological parameters of the visual analyzer, retardation of cortical-subcortical connections formation and lower electrical activity of the cerebral cortex. Amblyopic children show lower coefficients of mental development accompanied by intellectual deficiency and deterioration of learning ability. Proposed treatment method improved neurophysiological parameters of the visual analyzer in 83.5% of cases and increased visual acuity in 81.4% of cases. Improvement of psychological development resulted in better logical thinking, memory reinforcement and better adaptation to school educational environment in 86.6% of children.

Results of a Prospective Study Concerning the Clinical Efficiency of Recent Russian-Made Specialized Foods without Phenylalanine

Background : Specialized foods, based on aminoacids without phenilalanin, are the main source of protein for patients with phenilketonuria of all ages. Based on modern technologies, new Russian-made foods were created. They have an optimized aminoacid and micronutrient composition, which increases their bioavailability. Objective: Our aim was to investigate the clinical efficiency of the new Russian-made specialized foods based on aminoacids without phenylalanine, in patients with phenylketonuria. Methods : Evaluating physical, somatic and neuropsychic development as well as measuring phenylalanine blood level were carried out twice: before the prescription and after 1 month of using the new Russian-made specialized foods. The chemical composition of the ration was controlled using dietology methods. Results : 57 children at the age of 14 days to 15 years with phenylketonuria (which was detected in neonatal screening) were picked for this study. A hypophenylalanine diet has been prescribed for all children no later than at the age of 3 months of life. In children of the first year (I group) (among which there were children with high phenylalanine blood levels) phenylalanine concentration decreased from 5,5 (4,0; 21,0) to 4,4 (3,7; 4,7) mg/dl (p = 0,014) while using Russian-made specialized foods. In this group of children the psychomotor and physical indices improved. In early childhood-, preschool- and school-aged patients phenylalanine blood level remained steady. The chemical composition of the ration with Russian-made foods, based on aminoacids without phenylalanine, corresponded to the reference intake of main nutrients and energy. Conclusion : Hypophenylalanine diet with new Russian-made specialized foods without phenylalanine (which is designed for phenylketonuria patients of various age groups) showed high clinical efficiency of these foods.

Катамнез захворюваності та нервово-психічного розвитку дітей після перенесеної вродженої пневмонії упродовж першого року

Катамнез захворюваності та нервово-психічного розвитку дітей після перенесеної вродженої пневмонії упродовж першого року

Nuclear-physical analysis methods in medical geology: Assessment of the impact of environmental factors on human health

The procedure for geomedical studies is outlined, and the niche occupied by the nuclear-physical analysis methods in these studies is pointed out. The necessity of construction of an efficient complex of the most modern analytical methods is demonstrated. The metrological parameters of methods applied in the analysis of natural environments and biological materials are evaluated. The current state of pollution of natural environments with heavy and toxic metals is characterized in two specific industrial hubs: the towns of Gus-Khrustalny and Podolsk. The levels of pollution of diagnostic biological materials (hair and blood) from children living in various urban districts are studied in the light of specific features of the manufacturing industry in these towns and the life environment of child population. The results of studies focused on evaluating the effect of environment on the health of child population are detailed. The actual damage to child health, their neuropsychic development and behavior, and the effect of socioeconomic factors are determined. Preventive problems among the child population exposed to lead and other toxic metals are evaluated, and ways to solve them are proposed. A system of early diagnosis and preventive measures for the mitigation of adverse effect of toxic metals (Pb, Cu, Mn, Zn, Cr, Ni, As, etc.) on the neuropsychic development of children is developed based on an actual ecogeochemical estimation of the state of the region under study.

BREAST FEEDING SUPPORT IN PREMATURE INFANTS: PROBLEMS AND SOLUTIONS

научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных и вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии лекарственных средств на плод, о проводимых в

USING EXPERIENCE AND MODERN APPROACHES TO SELECTION OF ADAPTED FORMULA MILK FOR CHILDREN ON ARTIFICIAL FEEDING

Background : Modern approaches to feeding the children in the first year of life, especially when the artificial formula milk is indicated, necessitate the individual approach to the selection of formula in order to adequately provide the organism with micro- and macronutrients. Aim: The purpose of the study was to evaluate the effect of examined formula milk enriched in pro- and prebiotics on growth and development of the children in the first year of life. Patients and methods : The participants of the study were 75 children in the age between 1 and 5 months at the different feeding types. Group I (n = 25) was given a standard adapted formula milk, Group II (n = 24) — standard formula milk of the same brand, Group III (n = 26) — breast milk. Results : The study showed that when feeding with the breast milk body weight deficiency was observed in 19.4% of children, while body weight excess — in 15.4% of children. When feeding with the artificial milk, the excessive body weight was observed in 18.4%, while the body weight deficiency was recorded only in 12.2% of children. The analysis of examination results of children in the first year of life on the different feeding types showed the positive effect of the adapted formula milk on the health and development indices: the number of children with optimal physical and neuropsychic development has grown (from 72 to 88%), the functional condition of the gastrointestinal tract has recovered (posseting has reduced from 88 to 16% cases, flatulence — from 36 to 4%, intestinal constipation — from 60 to 4%, stool disorders — from 36 to 4%). Conclusion : The examined adapted formula milk can be successfully used in children in the first year of life when breast feeding is impossible.

Внедрение принципов успешного грудного вскармливания в системе оказания медицинской помощи детям, родившимся раньше срока

научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных и вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии лекарственных средств на плод, о проводимых в