The present investigation deals with the synthesis and characterization of oxide dispersed strengthened (ODS) alloys based on W79Ni10Nb5Mo5 (in weight %) with 1.0 wt% of nano Y2O3 (alloy A), TiO2 (alloy B) and ZrO2 (alloy C) respectively by mechanical alloying for 20 h using Ball to Powder weight ratios (BPR) of 10:1 and 5:1. X-ray Diffraction study reveals that the mechanically alloyed alloy A with 10:1 BPR possesses minimum crystallite size (11.15 nm). A high-resolution Transmission Electron Microscopy study shows that oxide particles are dispersed at the particle interface and matrix. HRTEM study also reveals different orientation of lattice fringes of the oxide with respect to the matrix with a positive and negative lattice misfit is evaluated in the alloys milled with 10:1 BPR.