This paper investigated the performance characteristics of misaligned journal bearing lubricated using couple stress fluids. Based on micro-continuum theory, the modified Reynolds equation for couple stress lubricants was developed, in which viscosity-pressure effect was considered. By setting the critical oil film thickness, the region with couple stress effect can be recognized. The ratio of the critical oil film thickness to couple stress parameter was referred to as film thickness coefficient. It was found from results that increase of film thickness coefficient can significantly improve the maximum film pressure and high-pressure area, when film thickness coefficient was smaller than 4. Viscosity-pressure effect was capable of enhancing viscosity, friction coefficient and the maximum film pressure, and reducing couple stress parameter, especially for large misalignment angle.